University of Amsterdam

Task-irrelevant stimuli robustly drive phasic pupil-linked arousal but only weakly affect memory formation

Abstract Brainstem arousal systems including the locus coeruleus noradrenaline system, respond transiently to behaviorally relevant events. This also drives dilations of the pupil, which are often observed during cognitive tasks. The strength of pupil responses during encoding of...

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

Redefining liver health: a multidimensional approach to preventing metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction–associated steatohepatitis (MASH) is a rapidly escalating global health challenge driven by complex interactions among metabolic regulation, nutrition, immune signalling, gut microbiota, and environmental exposures. Current disease-centric frameworks priorit...

Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis

Leukemia stem cells (LSC) are thought to be responsible for relapse in patient with acute myeloid leukemia (AML). LSC can be quantified at diagnosis to improve risk stratification, and during follow-up to monitor residual disease. To systematically evaluate the prognostic relevan...

Availability and representativeness of freshwater macroinvertebrate data to enable Europe-wide assessment of biodiversity trends

Freshwater ecosystems, though covering less than 1% of Earth's surface, harbor around 10% of all species. Pressures like pollution, water extraction, and habitat loss can exhibit complex interactions in their effects on freshwater biodiversity. Understanding the effects of these...

From commitment to communication: a roadmap for strategic communication of corporate digital responsibility

Purpose This article introduces a theoretically grounded and practice-oriented roadmap to guide communication professionals in translating corporate digital responsibility (CDR) from organizational commitment into effective communication practice. It seeks to clarify CDR communic...

The Dutch Prolactinoma Cohort Studies: Cross-sectional Analysis of Females Focusing on the Patient's Perspective

Abstract Purpose To assess the results of patient-reported outcome measures (PROMs) in a national cohort of females with a prolactinoma by disease activity. Methods Females with prolactinoma included in the PRolaCT or ProlaC study were assessed cross-sectionally, comparing patien...

Histoplasmosis in India: a systematic review of reported cases

BACKGROUND: Histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum and is increasingly recognised in India, but its epidemiology, clinical spectrum, diagnosis, treatment, and outcomes remain poorly characterised. We conducted a systematic review of reporte...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

Silent yet Not Deserted: Associations Between Ringer Modes, Mobile Phone Use, and Digital Stress

While digital disconnection and smartphone regulation have gained scholarly attention, little is known about phone setting customizations. Currently, there is inconsistent evidence on whether modifying ringer modes reduces actual smartphone use and digital stress. Some studies su...

Temporalities of destiny: Agency, relationality and divorce among women in Istanbul1

Abstract This article draws on the life stories of divorcing or divorced women living in Istanbul. By attending to my interlocutors’ transformations over time, in relation to others and divine power, it examines the complex workings of destiny and the idea of imtihan (test from G...

Converging pathomechanisms link SARS-CoV-2 infection with major neurodegenerative diseases

Neurological complications are among typical clinical manifestations, both during the acute phase of SARS-CoV-2 infection and long-term post-acute COVID-19 sequelae, i.e., Long COVID. A growing body of evidence connects SARS-CoV-2 infection to systemic inflammation, peripheral im...

Radiological Late Dental Adverse Effects Following Treatment for Paediatric Head and Neck Rhabdomyosarcoma: Results of a Transatlantic Multicentre Cohort Study

ABSTRACT Objectives Rhabdomyosarcoma represents the most common paediatric soft tissue sarcoma, with 40% occurring in the head and neck region. Given that survival rates now reach 80%, minimising late adverse effects, particularly dental developmental complications, has become a...

Bronchiectasis as an Underrecognized Extraintestinal Manifestation of Inflammatory Bowel Disease

ABSTRACT Introduction Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract, often presenting with extraintestinal manifestations (EIMs). The most prevalent pulmonary EIM is IBD‐associated bronchiectasis (IBD‐BE), which is often overloo...

Interobserver and intraobserver variability of fetal and maternal Doppler measurements: systematic review and meta‐analysis

ABSTRACT Objectives To evaluate the variability and reproducibility of umbilical artery (UA), fetal middle cerebral artery (MCA) and uterine artery (UtA) Doppler ultrasound measurements in pregnancy. Methods A systematic search of MEDLINE, EMBASE and the Cochrane Library (CENTRAL...

Recognition of ear, nose and throat involvement in patients with ANCA-associated vasculitis: from in-depth interviews to insights for the future

PURPOSE: Ear, nose, and throat (ENT) manifestations are common in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Although timely intervention is crucial, diagnosis and treatment are often delayed due to its rarity and nonspecific symptoms. Currently, no standard...

Quantifying the effects of prospective memory and ongoing task difficulty on capacity sharing and cognitive control

This study examines how individuals adapt to varying levels of prospective memory (PM) and ongoing-task difficulty in a cognitively demanding task environment. PM - the ability to remember and execute delayed intentions while engaged in other tasks - depends on flexible allocatio...

The Search for Life Elsewhere: Avoiding Hype and Fostering Public Understanding

The search for life beyond Earth presents unique challenges for science communication due to its interdisciplinary nature, the potential for groundbreaking discoveries, and the inherent uncertainties involved. The Lorentz Center workshop Breaking News: We Found Extraterrestrial L...

Measuring healthcare quality in police custody: the development of quality indicators through expert consultations in the Netherlands

Abstract Background Improving the quality of care for people detained in police custody requires careful measurement and monitoring. However, a standardized and endorsed set of quality indicators for healthcare in police custody settings is lacking. This study aimed to develop a...

A literature overview of age- and Tanner stage-specific reference intervals for sex hormones for children aged 0 – 18 years

Abstract Study objective This study aims to provide a comprehensive overview of age- and Tanner stage-specific reference intervals (RIs) for testosterone, estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) in children...