University of Amsterdam

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Integrating the social and solidarity economy into global health: towards structural transformation for equity, resilience, and sustainability

Abstract Global health is shaped by complex and interdependent challenges across social, commercial, environmental, technological, and political domains that cannot be solved by the health sector alone. In response, alternative economic models and paradigms have gained attention....

From Auditing to (Re)designing: Recommender Systems for User Empowerment in Very Large Online Platforms Under the Digital Services Act

The governance of recommender systems (RSs) in very large online platforms (VLOPs) is expected to change significantly under the Digital Services Act (DSA), which imposes specific obligations on algorithmic transparency and user control. However, beyond legal compliance, a critic...

When AI meets DEI: Employee AI-beliefs and their implications for workplace diversity, equity, and inclusion

As artificial intelligence (AI) reshapes the workplace, its impact on diversity, equity, and inclusion (DEI) has been examined primarily through the lens of what AI actually does (i.e., system design, outputs). This review shifts the focus to humans' subjective beliefs about AI,...

Bandwagons or breeding grounds for innovation: What economic elites’ private museums contribute to the arts

In recent decades, hundreds of private art collectors have opened museum spaces, which they largely finance and control themselves. While such initiatives have been criticized as conspicuous consumption or vanity projects, one public benefit claimed is the display of new artistic...

Who Is Afraid of ChatGPT? A Natural Experiment on the Effect of ChatGPT Release on Labour-Market Concerns

The public release of ChatGPT on November 30th, 2022 revived the public debate on technological change and, particularly, on its impact on the labour market. Despite the sudden growth in AI salience after the launch of the new chatbot, to our knowledge, no empirical investigation...

State Transfer in Discrete-Time Quantum Walks via Projected Transition Matrices

In this paper, we analyze state transfer in quantum walks by using combinatorial methods. We generalize perfect state transfer in two-reflection discrete-time quantum walks to a notion that we call peak state transfer; we define peak state transfer as the highest state transfer t...

Towards a suitable biomarker for childhood screening for familial hypercholesterolemia: a systematic literature review

Familial hypercholesterolemia (FH) is a common genetic disorder causing elevated low-density lipoprotein cholesterol (LDL-c) concentrations from birth, resulting in a high risk of premature cardiovascular disease. Despite effective early treatment, FH remains underdiagnosed in ch...

A fast radio burst at redshift 2, three billion years after the Big Bang

Fast radio bursts (FRBs) are millisecond-duration radio transients from extragalactic sources. Their frequency and polarization properties are affected by plasma and magnetic fields along the line of sight to Earth. We report radio observations of FRB 20240304B and near-infrared...

Escherichia coli -derived enterobactin is associated with delayed gut microbiome maturation in infants born to mothers with obesity

ABSTRACT Maternal obesity has been increasingly recognized as a factor influencing early-life microbiome development. However, its impact on the infant gut resistome and virulome remains insufficiently characterized. In this prospective longitudinal study, we investigated gut mic...

Treatment of male osteoporosis: a narrative review and position statement by the ECTS Clinical Action Group.

Osteoporosis in men is under-recognized and under-treated despite a substantial disease burden and poorer fracture-related outcomes than in women. Secondary osteoporosis is highly prevalent in men, making the identification and management of underlying causes essential. Bone mine...

From Sprain to End-Stage Osteoarthritis: Why Earlier Intervention in Ankle Cartilage Damage Deserves More Attention

➢ Ankle cartilage damage ranges from osteochondral lesions of the talus to end-stage osteoarthritis. End-stage ankle osteoarthritis has been associated with a health burden comparable with that of major chronic diseases such as congestive heart failure and kidney disease, while p...

Greening cities to ensure biosphere functional integrity: Insights from Rotterdam and Lagos

The Earth Commission has proposed that 20-25% of every square kilometre of managed lands, including in cities, be reserved for nature to ensure its local functioning and human wellbeing -biosphere functional integrity boundary (BFI). This research adopted a multi-method justice-o...

The precarious nature of musical encounters in healthcare: An ethnographic multi-case study focusing on the perspectives of care professionals and musicians

Background This paper presents an ethnographic multi-case study exploring how musical encounters in healthcare contribute to experiences of connection, focusing on the perspectives of care professionals and musicians. In addition to studies on music in healthcare that primarily e...

Liver X receptor (LXR) signaling in macrophage inflammation and cardiometabolic disease.

Cardiometabolic diseases profoundly remodel tissue immune landscapes, characterized by the accumulation of diverse macrophage subtypes. Among these, lipid-associated macrophages (LAMs) have emerged as an important subset that is frequently observed in cardiometabolically affected...

Self‐Assembly of a Colloidal Honeycomb Crystal in Silico for Topological Valley Photonics

The quest to employ colloidal self-assembly as a scalable means of fabricating photonic crystals with a complete photonic band gap at optical frequencies has proved challenging throughout the first quarter of the 21st century. Meanwhile, the field of topological photonics has eme...

Gut resilience and clinical homeostasis following administration of neomycin and albendazole in soil-transmitted helminth-infected adults living in Lambaréné, Gabon

Abstract Purpose Gut resilience and systemic homeostasis are interrelated dynamic functions. A gut that fails to regulate intestinal barrier integrity, metabolite production, and immune regulation will lead to systemic pathogenic invasion and susceptibility to infections. Gut res...

Energy-Transfer Pathways in Nd-Sensitized Er-Rich Nanostructures: The Competition between Cross-Relaxation and Phonon-Assisted Sensitization

Abstract Rare earth-doped upconversion nanomaterials, which convert near-infrared light into visible or ultraviolet light, are widely recognized as having a huge potential application market, which unfortunately is restricted by their obstinate insufficient luminescence efficienc...

Good Quality of Life 3 Decades After Rotationplasty

Background: Long-term quality of life (QoL) after rotationplasty is important because prolonged patient survival has become more common. This study assessed QoL decades after rotationplasty. Methods: This cross-sectional study included surviving patients who had been treated for...

Advertising with HAART: Introducing Human–AI Asymmetric Relationship Theory

Generative artificial intelligence (GenAI)is rapidly reconfiguring advertising from message delivery and optimization to relationship-like exchanges between consumers and brands. While existing work has explained these interactions through social response accounts and interperson...