University of Amsterdam

Time-dependent prognostic value of coronary plaque burden and hyperemic myocardial blood flow

Abstract Rationale The time-dependent contributions of coronary atherosclerotic plaque burden and myocardial ischemia to clinical outcomes in suspected coronary artery disease (CAD) remain uncertain. This study aimed to evaluate the temporal associations of quantitatively assesse...

Deciding on thresholds for clinical relevance of PROMIS-upper extremity v2.0 in patients with upper extremity injury

Abstract Purpose In this study we focused on gaining better interpretation of the PROMIS-Upper-Extremity v2.0 (PROMIS-UE v2.0) T-score scale for measuring upper extremity function in patients with upper extremity injuries (UEIs). This is fundamental in order to clearly understand...

No Easy Fix to Countering AI-Generated Visual Disinformation: The (in)Effectiveness of AI-Labels, Fact-Check Labels and Community Notes

As generative AI makes it easier to create synthetic visuals, AI-driven visual disinformation isbecoming more common on social media. However, while much research highlights its potentialharm, less is known about how to reduce its potential to mislead. In this study, we therefore...

Incidence of New Malignancies in Severe Asthma: Comparison of Real-World Patients Treated with Benralizumab, Other Biologics, or Non-biologics

Clinical trials report no increased malignancy risk with benralizumab in severe asthma; however, trial populations are highly selective. To better define real-world safety, malignancy risk was compared among patients treated with benralizumab, other (non-benralizumab) biologics,...

Long-Term Health-Related Quality of Life Outcomes in Patients With Cellulitis Requiring Hospitalisation

In 94 hospitalised patients with cellulitis, HRQoL was markedly impaired at admission and remained significantly below population norms at 90 days, particularly in patients with persistent pain and oedema. These findings highlight the need for post-discharge follow-up focused on...

Null fluid/gravity correspondence

A bstract We construct a new class of perturbative asymptotically Anti-de Sitter pp-wave spacetimes by performing a long-wavelength expansion of Kaigorodov metrics in arbitrary spacetime dimensions. Holographically, these spacetimes are described by a null fluid hydrodynamic expa...

How Norms Depend on the Presence and Status of Observers: The Relational Contingency of Everyday Behaviors in 90 Societies

Norms are fundamental to social life, but basic questions about how they are affected by social context remain. Specifically, how do normative constraints depend on the presence and status of observers, and how do such relational contingencies vary across cultures? Using data fro...

Effect of EMDR for reduction of pain interference in children with sickle cell disease, the RELAX study: a randomized controlled trial protocol

BACKGROUND: Children with sickle cell disease (SCD) suffer from vaso-occlusive crises, extremely painful episodes that may require hospitalization. Traumatic experiences during hospitalization and frequent pain experiences may lead to psychological distress and the development of...

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Abstract Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The re...

Divergent complication patterns of type 2 diabetes in African individuals who are lean versus overweight or obese: a multi-cohort analysis

Abstract Aims/hypothesis Nearly 40% of African adults with type 2 diabetes are lean (BMI <25 kg/m 2 ). Emerging evidence suggests that type 2 diabetes in African individuals who are lean may represent a distinct phenotype driven by impaired insulin secretion rather than insulin r...

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

Risk Theory in a Finite Customer-Pool Setting

This paper investigates an insurance model with a finite number of major clients and a large number of small clients, where the dynamics of the latter group are modeled by a spectrally positive Levy process. We begin by analyzing this general model, in which the inter-arrival tim...

P1.175. Lymph Node Assessment of the Thoracic Duct and Surrounding Compartment in Esophageal Cancer Surgery – the TUPEC Pilot-Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Standardization of thoracic duct (TD) management during esophageal cancer surgery remains controversial. TD resection has been hypothesized to enhance oncologic radicality, since it may increase...

P1.174. Fluorescence Guided Lymph Node Dissection Using Indocyanine Green During Minimally Invasive Esophageal Cancer Surgery [IGLO] - Pilot-Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Standardization of lymphadenectomy extent in esophageal cancer surgery is complex due to the heterogenous lymphatic drainage patterns. Fluorescence guided lymph node dissection using...

Children’s Differential Susceptibility to Peer Acceptance and Rejection: A Multi-informant Longitudinal Study

In this multi-informant longitudinal study, we examined whether children with higher levels of self-reported sensory processing sensitivity (SPS) showed stronger longitudinal associations between peer relationships (i.e., peer acceptance and rejection) and their social-emotional...

From words to sentences: designing and evaluating a parent-facing sign language learning app

Abstract To prevent language deprivation, hearing parents of deaf and hard-of-hearing children need to learn sign language as soon as possible after their child’s hearing loss is identified. However, sign language resources for parents are limited and often lack focus on sentence...

Celestial amplitudes on electromagnetic backgrounds: T-duality from S-duality

Abstract What is the boundary holographic dual of S-duality for gauge theories in asymptotically flat space-times? Celestial amplitudes, by virtue of exhibiting holographic properties of the S-matrix, appear well-suited for studying this question. We scatter electrically and magn...

Sociotechnical synergy: how employee involvement unlocks the value of data analytics

Purpose Despite high expectations about the benefits of data analytics (DA), our understanding of the mechanisms that drive value creation from the implementation of DA in firms remains incomplete. While some studies have suggested that innovation prowess, human resources and ope...

A reinforcement-driven multiple-instance learning method for multi-task speaker attribute prediction

Abstract Standard models for predicting speaker attributes from text often fail to manage multiple, interdependent attributes simultaneously, and existing Reinforced Multiple-Instance Learning (RL–MIL) frameworks are typically limited to single-task prediction. To address this, w...

Parent Mental Health From Preterm Birth Through the NICU Stay

OBJECTIVES: Preterm birth and neonatal intensive care unit (NICU) admission are not only extremely stressful for the infant itself but can also impact parental mental health. This Dutch national prospective cohort study aimed to describe the trajectory of parental mental health f...