University Medical Center Utrecht

Voxel-Matching NORDIC: Non-local patch formation by time-series similarity increases tSNR in high-resolution BOLD fMRI

Submillimeter functional magnetic resonance imaging (fMRI) based on blood-oxygenation-level-dependent (BOLD) signal enables the study of brain function at the submillimeter level, uncovering insights into fine-scale organisations like cortical layers and columns. However, its inh...

Adherence to treat-to-target recommendations in juvenile idiopathic arthritis in clinical practice

Abstract Objective To assess adherence to Treat-to-Target (T2T) recommendations for juvenile idiopathic arthritis (JIA) in clinical practice. Methods A nested cohort study in the multicenter international prospective UCAN JIA cohort was performed. Patient characteristics, clinica...

Quantitative framework for synthesising defocus-curve evidence in simultaneous-vision intraocular lenses

Background/aims To develop a quantitative, meta-analytic framework to synthesise defocus-curve evidence and describe functional visual performance of simultaneous vision intraocular lenses (SVIOLs) across clinically relevant visual ranges. Methods PubMed was searched from incepti...

A framework for outcome determination of nosocomial pneumonia treatment in ventilated critically ill patients

Abstract Background Treatment failure of hospital-acquired (HAP) and ventilator-associated pneumonia (VAP) is a common endpoint in clinical research, yet the absence of a reproducible definition hampers comparability across studies. We propose an operational framework for assessi...

Selective immunoglobulin A deficiency and coeliac disease: Immune response dynamics

Abstract Objective To analyse the serological immune response in paediatric patients with selective immunoglobulin A deficiency (SIgAD) and coeliac disease (CeD), focusing on immunoglobulin G antibody dynamics after starting the gluten‐free diet (GFD). Methods Data from SIgAD pat...

Heart failure with a preserved ejection fraction: synergy between cardiac and extracardiac mechanisms and effects of novel therapies

Heart failure with preserved ejection fraction (HFpEF) is a systemic disease in which metabolic comorbidities obesity, type 2 diabetes (T2D), and chronic kidney disease (CKD) converge to drive systemic inflammation, endothelial dysfunction, and myocardial fibrosis. Microvascular...

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Living donor valves for valve replacement in pediatric patients, come with the risk of immune rejection of the implanted tissue. To address this, and increase the options for living implants in pediatric patients, we previously developed a lentiviral immune-shielding strategy tha...

Design of a nonlinear double-breast single-axis gradient coil with controlled anterior–posterior gradient variation for diffusion-weighted imaging

Abstract Introduction High-performance whole-body gradient systems show promise for breast diffusion-weighted imaging, but their performance is constrained by physiological limits. Although local nonlinear gradient coils can provide stronger gradients while remaining within these...

Communicating the uncertainty of individual risk from clinical prediction tools with the PGower similarity measure

Clinical prediction models offer risk estimates for individual patients that are uncertain, even when calibration and performance at the population level are good. We compute Gower’s distance between patients in the training dataset to construct a metric against which new patient...

Towards network-based care: a three-phase study to explore the Networkintake as an entry point into network-oriented mental health services

Background A systemic transformation toward recovery-oriented, network-based care is essential to address persistent challenges in mental health services. To catalyze this transformation, the Networkintake approach has been developed to support a participatory approach to a compr...

Cutting to the Truth: Are We Measuring Osteotomy Parameters Correctly?

Purpose Traditional lower limb deformity analysis in pediatrics and adults centers on the anatomical center of the knee. However, in high tibial osteotomy (HTO) for medial compartment knee osteoarthritis (KOA), the surgical goal is often valgus overcorrection toward a lateral wei...

Witzel Versus Stamm‐Like Technique in Laparoscopic Feeding Jejunostomy: A Comparative Analysis of Complications

BACKGROUND: Feeding jejunostomy (FJ) is a key procedure to ensure proper nutrition in complex gastrointestinal surgeries and upper gastrointestinal (GI) obstruction. Over time, many techniques have been employed. In our unit, the preferred technique was Stamm's. Following an obse...

DUTCH weight control in atrial fibrillation study (DUTCH-WAIST)

Abstract Background Obesity is a well-established and highly prevalent risk factor for atrial fibrillation (AF) and its progression by promoting structural and electrical atrial remodelling, leading to AF recurrence and persistence. Weight loss is expected to reverse atrial remod...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Lung-shunt fraction measured in the intervention room directly after Tc-99m-MAA injection in hepatic radioembolization

Hepatic radioembolization treatments consist of two sessions: a pre-treatment procedure for safety and planning, and, if a suitable particle distribution is achieved, the subsequent treatment. Merging these into a single-session procedure could reduce costs and increase patient c...

Comparison of High‐Sensitivity Troponin T Versus N‐Terminal Pro‐B‐Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery

Background Preoperative hs‐TnT (high‐sensitivity cardiac troponin T) and NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) are used for risk prediction in noncardiac surgery. While the European Society of Cardiology recommends hs‐TnT, American Cardiology and European anesthes...

Assessment of threshold-based infarct core and penumbra segmentations from spectral CT angiography iodine density maps

Abstract CT perfusion (CTP) can differentiate infarct core (IC), penumbra (PEN), and healthy area (HA) in acute ischemic stroke. Quantitative iodine density maps from spectral CT angiography (CTA) may offer a lower-dose alternative. This study evaluated whether thresholding relat...

Proteomic analysis of aqueous humor from patients with Fuchs endothelial corneal dystrophy reveals downregulated expression of HSP60

The aim of the study is to identify proteins with differential abundance among aqueous humor (AqH) samples from patients with mild or advanced Fuchs endothelial corneal dystrophy (FECD) compared to control subjects. Proteins were extracted from AqH samples and analyzed by liquid...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Sex-specific associations of the plasma-proteome with incident coronary artery disease

AIMS: The etiology of coronary artery Disease (CAD) appears different for men and women, yet insights into underlying sex-specific biological mechanisms are limited. We integrated genomic and proteomic analyses to investigate sex-specific associations of the plasma-proteome with...