University Medical Center Utrecht

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

Longitudinal analysis of the B-cell receptor repertoire across 30 years of ageing

Abstract Background The gradual decline in the functionality of the immune system during aging is commonly referred to as immunosenescence. This study aims to investigate changes in the B-cell receptor immunoglobulin heavy chain (BCR IGH) gene repertoire during natural aging and...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Assessment of the plane of maximum curvature in adolescent idiopathic scoliosis using 3D ultrasound

Aims The size of the curves in patients with adolescent idiopathic scoliosis (AIS) is traditionally assessed using 2D Cobb angles, which may underestimate the extent of this complex 3D deformity. The plane of maximum curvature, measured using 3D reconstructions of the spine, incl...

Prospects of HIV elimination among men who have sex with men: A systematic review of modeling studies

Abstract Background Despite advances in HIV treatment and prevention, men who have sex with men (MSM) remain disproportionately affected by HIV worldwide. This systematic review summarizes the results of mathematical modeling studies that evaluated whether interventions might eli...

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Abstract Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should...

Early definitive fracture fixation (EDFF) does not alter circulatory neutrophil activation status in physiologically restored polytrauma: a 72-h porcine observation study

Abstract Dysregulation of the cellular innate immune system, particularly involving leukocytes and mainly neutrophils, underlies post-traumatic inflammatory complications. Early definitive fracture fixation (EDFF) triggers immune activation and may exacerbate inflammatory complic...

The effect of freshwater biases on AMOC stability across the model complexity spectrum

Abstract A collapse of the Atlantic Meridional Overturning Circulation (AMOC) would have strong consequences for the global climate system. Assessing whether the AMOC will collapse in the future is difficult since current Earth System Models (ESMs) have biases. An earlier study u...

Severity of Reactions in Double-Blind Placebo-Controlled Food Challenges: New Insights From the EuroPrevall Outpatient Clinic Study

BACKGROUND AND OBJECTIVES: Oral food challenge, particularly double-blind placebo-controlled food challenge (DBPCFC), is the gold standard for diagnosis of food allergy, although safety concerns limit its widespread use. Objectives: To evaluate the severity of reactions during DB...

Correlation of [ 68 Ga]Ga-RAYZ-8009 PET/CT Uptake with Immunohistochemical Glypican-3 Expression in Hepatocellular Carcinoma: A Proof-of-Target Study

Glypican-3, a cell-surface proteoglycan, is overexpressed in most hepatocellular carcinomas (HCCs). Recently, the glypican-3–targeted PET tracer [68Ga]Ga-RAYZ-8009 was shown to enable noninvasive detection of HCC. This retrospective analysis evaluates the correlation between tumo...

SRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors

ABSTRACT SRF fusion genes drive the pathogenesis of muscle-related soft tissue tumors, including subsets of perivascular tumors, inflammatory myofibroblastic tumor, and rhabdomyosarcoma. SRF encodes Serum Response Factor, a well-characterized transcription factor that regulates m...

Exploratory Continuous-Time Modeling (Expct): Extracting Dynamic Features from Irregularly Spaced Time Series

model: (1) addresses intensive data across virtually any time scheme, (2) allows for data collected at different time scales to predict themselves and one another, and (3) makes fewer assumptions about the functional forms of the longitudinal system dynamics between variables.

The pre‐dispute phase up close: experiences of visitors to Dutch legal aid centres

Abstract Given indications of rising challenges for marginalized citizens in the pre‐dispute phase of civil procedures, we studied this phase up close at Dutch legal aid centres using the framework of William Felstiner et al. on naming, blaming, and claiming. Interviews were cond...

Tumor Necrosis is Associated with an Increased Metastatic and Cardiovascular Risk in Paragangliomas: A Single-Center Series and Meta-Analysis Comparing Necrosis and Cystic Degeneration in Paragangliomas

Abstract Paragangliomas (PGLs) are rare neural crest–derived tumors with highly variable morphology and clinical behavior. These tumors can present with cystic and necrotic alterations that may influence the clinical presentation of affected patients. However, prevalence and clin...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

P1.238. Postoperative Outcomes in Patients After Prolonged Intensive Care Unit Stay After Esophagectomy: A Prospective Single-Center Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Prolonged intensive care unit stay (≥7 days) is common after esophagectomy. Although prolonged ICU stay after major surgery is associated with poor short- and long-term outco...

Intraoperative Adverse Events in Robot-assisted Minimally Invasive Esophagectomy (RAMIE)

Objective: Assess the incidence and management of intraoperative adverse events (IAEs) during robot-assisted minimally invasive esophagectomy (RAMIE) and evaluate their impact on postoperative outcomes. Background: IAEs are an inherent component of surgical practice and owing to...

Parent Mental Health From Preterm Birth Through the NICU Stay

OBJECTIVES: Preterm birth and neonatal intensive care unit (NICU) admission are not only extremely stressful for the infant itself but can also impact parental mental health. This Dutch national prospective cohort study aimed to describe the trajectory of parental mental health f...

“A beautiful chaos¨: a qualitative study on exploring the role of international communities of practice in knowledge translation for sexual and reproductive health and rights

Persistent knowledge-to-action gaps in sexual and reproductive health and rights (SRHR) limit the translation of evidence into policy and practice. Knowledge platform Share-Net International (SNI) uses Communities of Practice (CoPs) to support knowledge exchange, yet little is kn...

Epidemiologic and genetic evidence linking peripheral neuropathy to gut dysbiosis: a systematic review

Peripheral neuropathy affects a substantial proportion of the global population and remains incompletely explained by established risk factors. Preclinical studies suggest that gut dysbiosis can modulate neuroimmune pathways and neuropathic phenotypes. However, synthesis of human...