University Medical Center Groningen

Mucosal melanoma in 1481 patients in the Netherlands. An overview of metastatic patterns, main driver mutations and the efficacy of therapeutic strategies

Mucosal melanomas are a rare melanoma subtype with poor prognosis. This project aimed to identify the main driver mutations of the different mucosal melanomas and to evaluate the efficacy of targeted/immunotherapies in patients with metastatic disease in current practice. In addi...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Goal-directed nutritional support in preserving muscle mass and optimising recovery in treatment of oesophageal cancer: results of a prospective non-randomised cluster trial

Abstract Purpose Oesophageal cancer (OEC) treated with neoadjuvant chemoradiotherapy (CRT) followed by oesophagectomy is associated with muscle loss and impaired recovery. We aim to evaluate whether a goal-directed nutritional support protocol (GDNS) is associated with muscle los...

Meta-regression model choice and the interpretation of trial-level surrogacy

The use of surrogate endpoints can improve feasibility of clinical trials. The results of trial-level analyses are a key factor affecting regulatory policy regarding the uptake of a surrogate endpoint. Trial-level analyses aim to quantify the strength of association between treat...

Early Radiographic Changes Predict Radiographic Stability in Distal Radius Fractures: Development and Validation of an Explainable Predictive Model

Purpose To determine whether early radiographic trajectory data can predict the timing of stability in conservatively managed distal radius fractures (DRFs) and to identify which clinical and radiographic features most influence stabilization timing. Methods This retrospective co...

Subsite-specific prediction of lymphatic spread in head-and-neck cancer using a mixture of hidden Markov models

Abstract Head-and-neck squamous cell carcinomas (HNSCC) metastasize to neck lymph nodes. Radiation treatments include the elective irradiation of lymph node levels (LNLs) at risk of harboring occult (clinically undetected) metastases. We present a statistical model for personaliz...

A Comparison of Medial and Lateral Ligament Balance in Functional Versus Simulated Mechanical Alignment in Total Knee Arthroplasty Across CPAK Phenotypes: A Single-Center Study

Background/Objectives: Despite the excellent long-term outcomes of total knee arthroplasty (TKA), up to 10% of patients remain dissatisfied. Robotic-assisted TKA enables individualized alignment strategies, such as functional alignment (FA). Proper alignment and soft tissue balan...

Familial aggregation of cardiometabolic traits and long-term cardiometabolic risk in offspring: a 15-year prospective analysis from the PREVEND cohort

Family history is a well-established predictor of cardiometabolic risk; however, the independent prognostic contribution of sibling disease history, beyond parental history, remains to be elucidated. Using data from the prospective population-based Prevention of Renal and Vascula...

Categorizing race profiles in professional men’s and women’s road cycling races using clustering

Abstract Background Professional road cycling races differ in physiological demands because race profiles vary. Yet no standardized method exists to categorize race profiles across professional road cycling races. Organizer labels are inconsistent or missing. Systematic categoriz...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Developing an interprofessional self-reflection logbook in reproductive health in low-middle income countries: educational design research

PURPOSE: Remoteness from institutions challenges supervision in interprofessional education (IPE) in a community setting in reproductive health in low- and middle-income countries (LMIC). In this setting, IPE would benefit from an instrument that supports self-reflection. The use...

Interprofessional identity development: awareness as the beginning of change

Abstract Background: Developing an interprofessional identity (IPI) generates an intrinsic motivation for interprofessional collaboration owing to pro-diversity beliefs that mitigate identity threat within dynamic teams. However, personal experiences and contextual changes such a...

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Abstract Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should...

Respiratory viruses induce ferroptosis-like features in lung epithelial cells

During infection, viruses can modulate various regulated cell death (RCD) mechanisms to evade host immunity and enhance replication. However, less is known about how viruses alter the recently discovered RCD ferroptosis, which is characterized by an iron-dependent accumulation of...

Long-term outcomes of childhood ADHD stimulant use trajectories

Background. Stimulant medication is the first-line pharmacological treatment option for children with attention-deficit/hyperactivity disorder (ADHD). However, long-term effects remain unclear. Therefore, we explored long-term (>12 years) outcomes of childhood stimulant medicatio...

Long-term patient-reported knee-related outcomes and quality of life of patients with tibial plateau fractures: A mixed-methods study

Abstract Purposes This study aims to 1) provide a comprehensive assessment of the long-term functional outcomes in patients who sustained a tibial plateau fracture by combining patient-reported outcomes and a qualitative analysis of their healthcare experiences and 2) compare the...

Priority setting for older adult vaccines in Indonesia: a multi-criteria decision analysis using SMART vaccines

BACKGROUND: Indonesia's aging population faces substantial vaccine-preventable disease burdens, while vaccine introduction decisions remain constrained by limited resources and the absence of a prioritization framework. This study prioritized vaccines for older adults in Indonesi...

Feasibility and usability of mirror therapy in a virtual environment in phantom limb pain management: an exploratory mixed methods study

The interest in the use of mirrors and virtual reality techniques as a treatment to alleviate phantom limb pain has increased in the last few years. Our aim was to examine the feasibility and usability of using the mirror box technique in a virtual reality (VR) environment in com...

Roux‐en‐Y Reconstruction After Esophagectomy for Postoperative Functional Complaints: A Case Series

ABSTRACT Background Esophagectomy with gastric conduit reconstruction is associated with functional complaints impacting quality of life in approximately half of patients, including delayed gastric emptying and reflux. Current management strategies have limited effect, and no sta...