University Medical Center Groningen

Linking nasopharyngeal and oropharyngeal microbiota to immune responses during influenza-like illness in an aging population

Older adults are vulnerable to influenza-like illness (ILI). To study how infection shapes the respiratory microbiota, we profiled nasopharyngeal (NP) and oropharyngeal (OP) communities alongside local immune mediators in adults aged 60–88, comparing asymptomatic, ILI, and recove...

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

The Fiscal Consequences Attributed to Multiple Myeloma in Slovakia: There is No Small Disease

Abstract Background The incidence of multiple myeloma (MM) is rising in ageing populations. New therapies have improved survival but are among the most expensive in oncology. The consequences of MM for government revenues and expenditures in Slovakia have not been quantified. Met...

Hemocytometric Parameters Associated with Bacterial and Viral Etiology in COPD Exacerbations: An Exploratory Analysis

Exacerbations of Chronic Obstructive Pulmonary Disease (ECOPD) are often triggered by bacterial and viral infections, yet current diagnostic methods are time-consuming and biomarkers (e.g. C-reactive protein (CRP)) show limited accuracy in differentiating between these triggers....

Substantial improvement in short-term survivorship in patients receiving robotic arm-assisted medial unicompartmental knee arthroplasty

Aims Robotic arm-assisted unicompartmental knee arthroplasty (R-UKA) has been shown to improve alignment and accuracy of component placement compared with conventional unicompartmental knee arthroplasty (C-UKA). Despite this, there is conflicting evidence for whether this has an...

A trans-therapeutic signature of recovery in internet gaming disorder: From shared network reorganization to molecular underpinnings.

Background and aims: A variety of self-regulation interventions have shown efficacy in treating Internet Gaming Disorder (IGD), but their shared and unique neurobiological mechanisms remain unclear. This study aims to identify a common, trans-therapeutic neural signature of recov...

Disproportionate systolic blood pressure response relative to oxygen consumption identifies a high-risk haemodynamic phenotype in arterial hypertension

OBJECTIVES: Conventional definitions of hypertensive response to exercise (HRE) rely on absolute systolic blood pressure (SBP) thresholds, which do not account for the metabolic demand driving the pressor response and show inconsistent association with pathophysiology and prognos...

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial

Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...

Impacting Rare Diseases Healthcare by Case‐Based Telelearning: Description of the Dutch Pilot Metabolic Diseases ECHO

ABSTRACT Inherited metabolic diseases (IMDs) are individually (ultra)rare but collectively relatively common. The Extension for Community Healthcare Outcomes (ECHO) model has been used worldwide since 2003 to disseminate knowledge and best practices in chronic diseases. In 2024,...

Urine Ammonium During Normothermic Machine Perfusion as a Marker of Donor Kidney Function

Background. Optimizing graft selection remains a central priority, and normothermic machine perfusion (NMP) provides a potential platform for pretransplant organ assessment. Kidney ammonium excretion quantifies proximal tubular and interstitial function. This study investigated u...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Concurrent synchronization and covariation in upper extremity joint angles during a reciprocal aiming task

Abstract The ecological-dynamical approach holds that movement is self-organized, implying a circular causality between the kinematics of the end-effector and the coordination of degrees of freedom (DOF) into synergies. Yet, how this circular causality manifests itself in redunda...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Weighting of Spectral and Temporal Cues with n-of-m Cochlear Implant Strategies Depends on Voice Pitch

Abstract Purpose The relative contributions of spectral and temporal cues to voice pitch perception in cochlear implant (CI) users remain unclear. This study aimed to directly quantify these contributions in dynamic speech stimuli with clinical n -of- m processors. Methods Fundam...

TNFR2 agonist treatment differentially affects neuropathology and neuroimmune responses in male and female 3xTg-AD mice

Neuroinflammation is a central contributor to Alzheimer’s disease (AD) progression, with tumor necrosis factor alpha (TNF-α) playing a key regulatory role as a master pro-inflammatory cytokine. While therapies inhibiting total TNF-α have produced inconsistent results and adverse...

Cellular senescence: six decades of discovery and reinvention

Abstract Cellular senescence has undergone a remarkable conceptual evolution since its discovery in 1961. Initially described by Hayflick and Moorhead as the finite proliferative lifespan of cultured human cells, senescence was first viewed as a consequence of cellular aging. The...

Toward the Use of Real‐World Data for Regulatory and HTA Decision‐Making: Experiences and Recommendations from Six EU ‐Funded Projects

Real-world data are increasingly important for regulatory and health technology assessment decision-making, yet their effective use across Europe remains limited by technical, methodological, regulatory, and societal challenges. Drawing on the experiences of six Horizon Europe pr...

Unsulfated secondary bile acids and structurally defined pectins modulate intestinal barrier responses under acute hyperglycemic conditions in intestinal epithelial co-cultures

The intestinal epithelial barrier maintains gut homeostasis and limits systemic inflammation. Barrier dysfunction is linked to metabolic disorders including diabetes, yet the combined effects of hyperglycemia, microbial metabolites, and dietary polysaccharides on epithelial integ...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Evaluation of nationwide variation in post-haemorrhagic ventricular dilatation management following national guideline implementation in the Netherlands

Abstract Purpose Post-haemorrhagic ventricular dilatation (PHVD) is a severe complication of germinal matrix–intraventricular haemorrhage in preterm infants and is associated with significant morbidity and adverse neurodevelopmental outcomes. In 2023, national recommendations for...