University Medical Center Groningen

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...

Endotracheal intubation practices, success rates and adverse events in four Dutch emergency departments: a multicentre retrospective study

Endotracheal intubation in the emergency department (ED) is a high-risk intervention associated with significant complications. Contemporary European data on emergency airway management remain limited, and no published data are available from the Netherlands. This study aimed to...

Application-based coaching for recurrent urinary tract infections in adult women: design of a mixed-methods multicenter randomized controlled trial and process evaluation in the Netherlands

Abstract Background Recurrent urinary tract infection (rUTI) healthcare has proven to be a challenge due to different limitations. Digital coaching could provide a solution for these challenges. Earlier, we have developed a digital coach for women with rUTI and pilot-tested this...

Parent Mental Health From Preterm Birth Through the NICU Stay

OBJECTIVES: Preterm birth and neonatal intensive care unit (NICU) admission are not only extremely stressful for the infant itself but can also impact parental mental health. This Dutch national prospective cohort study aimed to describe the trajectory of parental mental health f...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Lead‐Associated Superior Vena Cava Syndrome: Diagnostic Delay and the Role of Invasive Pressure Measurements

ABSTRACT Superior vena cava (SVC) syndrome is an uncommon complication of transvenous cardiac device leads. Diagnosis may be challenging due to gradually developing and nonspecific symptoms. Furthermore, anatomical imaging does not always reflect the hemodynamic significance of v...

Performance evaluation of a position-sensitive SiPM-based gamma camera for intraoperative imaging

Abstract Background The POSiCS camera is a handheld and wireless, small field-of-view gamma camera developed for use in radio-guided surgery (RGS), with sentinel lymph node biopsy (SLNB) as its benchmark application. This compact and lightweight detector (about $$350\,\textrm{g}$...

Physician-Modified Cook Zenith Alpha Thoracic Endovascular Graft with Preservation of Active Fixation Barbs: A Step-by-Step Technical Guide

Physician-modified endografts (PMEGs) represent an important treatment option for urgent and semi-urgent complex abdominal aortic aneurysms (cAAAs). The Zenith Alpha Thoracic Endovascular Graft (Cook Medical, Bloomington, IN, USA) is a common choice for PMEGs due to its low strut...

Failure to recognise residual neuromuscular blockade in a patient with hemiparesis: a case-based report describing a limitation of quantitative neuromuscular monitoring

The use of non-depolarising neuromuscular blocking agents (n-NMBAs) necessitates intraoperative neuromuscular function monitoring, as undetected residual neuromuscular blockade increases the risk of postoperative complications. The use of intraoperative quantitative neuromuscular...

Acute adaptations in dynamic torque and torque control to practicing with known and unknown sequences of concentric and eccentric muscle contractions in healthy young adults

Abstract Background During human movement, the neuromuscular system continuously adapts to varying and differently predictable demands. Practicing with sequences of known and unknown types of muscle contractions could train force control of muscle. We compared the acute effects o...

Cardiovascular Risk Prediction with the Kidney Failure Risk Equation in the Chronic Renal Insufficiency Study

Background: The Kidney Failure Risk Equation (KFRE) is an established tool to predict the risk of kidney failure among patients with CKD. Patients with CKD more often die from cardiovascular (CV) causes than renal causes, and more often experience a non-fatal CV event than progre...

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...

The Dutch Prolactinoma Cohort Studies: Cross-sectional Analysis of Females Focusing on the Patient's Perspective

Abstract Purpose To assess the results of patient-reported outcome measures (PROMs) in a national cohort of females with a prolactinoma by disease activity. Methods Females with prolactinoma included in the PRolaCT or ProlaC study were assessed cross-sectionally, comparing patien...

Mechanism of Autophagic Extracellular Vesicles Revealed

Recent work by Mao and colleagues identifies a distinct class of small extracellular vesicles, termed autophagic extracellular vesicles (AEVs), generated from amphisomes upon autophagy induction. In this commentary, we discuss how this study provides important mechanistic insight...

District nursing staff’s experiences with implementing an evidence-informed triage instrument for delirium in home care; an action research-informed qualitative study

Abstract Background Timely recognition of delirium in people living at home remains challenging, despite the availability of evidence-informed approaches. District nurses and nursing assistants play a key role in translating such evidence into daily practice. This study aimed to...

Liver-directed gene therapy results in amelioration of progressive familial intrahepatic cholestasis type 2 in mice

Background: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare disease affecting the ABCB11 gene, encoding the bile salt export pump (BSEP). BSEP dysfunction impairs bile acid (BA) secretion, causing hepatic damage and leading to pruritus, cholestasis, hepatom...

Psychological interventions to improve maternal mental health and resilience during pregnancy in the COVID-19 pandemic: a systematic review

BACKGROUND: During the COVID-19 pandemic, pregnant women experienced increased psychological distress, while access to routine mental health care was often disrupted. Psychological interventions may provide an effective strategy to support maternal mental health under these circu...

DAVE: how to use explainable AI to interpret missense variants for genome diagnostics based on functional protein modeling

<ns5:p>Background Diagnostic yield in NGS genome diagnostics is constraint by the high fraction of variants of uncertain significance (VUS), largely due to poor interpretability of missense variation. Current pathogenicity predictors often provide strong performance but lack mech...

The impact of nephrectomy on liver and contralateral kidney volume in patients with ADPKD; a case series

A substantial number of patients with autosomal dominant polycystic kidney disease (ADPKD) undergo nephrectomy. A decrease in intra-abdominal pressure after nephrectomy might hypothetically accelerate the growth of other polycystic organs and accelerate the rate of eGFR decline o...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...