University Medical Center Groningen

Recovery trajectories and predictors of symptom resolution in post-COVID-19 condition: a population-based cohort study

Background SARS-CoV-2 infection can lead to persistent symptoms, known as Post-COVID-19 Condition (PCC). Previous studies on PCC prognosis mainly looked at severe cases in rehabilitation settings and without knowledge about pre-infection symptom levels. Uncertainty remains about...

Interobserver and intraobserver variability of fetal and maternal Doppler measurements: systematic review and meta‐analysis

ABSTRACT Objectives To evaluate the variability and reproducibility of umbilical artery (UA), fetal middle cerebral artery (MCA) and uterine artery (UtA) Doppler ultrasound measurements in pregnancy. Methods A systematic search of MEDLINE, EMBASE and the Cochrane Library (CENTRAL...

Using the Interpersonal Theory of Suicide to Inform Our Understanding of Suicide Risk in Autism Spectrum Disorder: A Scoping Review

Abstract This scoping review is the first to systematically map the literature on suicidality in autistic adults through the lens of Joiner’s Interpersonal Theory of Suicide (ITS). Reviewing 51 studies and distinguishing between those directly assessing ITS constructs and those c...

Osteochondral Autograft Options for Reconstruction of Intra-articular Distal Humerus and Proximal Ulna Injuries in Physiologically Young Patients

Purpose Surgical options are limited for distal humerus and proximal ulna injuries with articular bone loss in physiologically young patients. Osteochondral grafts are a potential treatment option between open reduction internal fixation and arthroplasty that does not impart life...

Autonomous AI in prostate cancer: the road ahead towards clinical implementation

Abstract Artificial Intelligence (AI) for detecting clinically significant prostate cancer (csPCa) on MRI has achieved diagnostic performance comparable to that of radiologists. By autonomously interpreting examinations, AI could improve workflow efficiency and help address incre...

Effect of genetic factors on [18F]FDG PET metabolic phenotypes in dementia with Lewy bodies

BACKGROUND: F]FDG PET can support the diagnosis of Dementia with Lewy Bodies (DLB), but it remains unclear how genetic factors influence metabolic phenotypes. OBJECTIVES: F]FDG PET metabolic patterns in DLB. METHODS: F]FDG PET scans from 43 patients with DLB stratified by GBA1 an...

Transcranial alternating current stimulation as treatment for delirium: A multicenter randomized double-blind sham-controlled pilot study on safety and feasibility

Delirium is an acute neuropsychiatric syndrome with currently no effective treatment. The acute encephalopathy underlying delirium is characterized by diffuse oscillatory slowing on electroencephalography (EEG). Based on its capacity to modulate oscillatory activity, 10 Hz transc...

Plain language summary of how acoramidis affects the total number of heart problems over time in people with ATTR-CM: findings from the ATTRibute-CM study

Plain Language SummaryWhat is this summary about?Transthyretin amyloid cardiomyopathy (ATTR-CM) happens when transthyretin (TTR) protein breaks apart, forming clumps that build up in the heart, making it harder to pump blood.People with ATTR-CM often go to the hospital multiple t...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

A proposed approach for involving general practice in integrated oncological decision-making for frail patients

As populations age, the number of older adults (≥70 years) diagnosed with cancer is increasing, now accounting for the majority of new cancer diagnoses and experiencing the highest treatment burden. Treatment decision-making in this population is often complex, as multimorbidity,...

Extended haplotypes at the complement factor H gene locus are associated with liver transplant rejection.

BACKGROUND: Acute T-cell-mediated rejection (ACR) remains an important complication after liver transplantation. Polymorphisms in the factor H gene (CFH) and factor H-related protein genes (CFHRs) affect the risk of multiple complement-related diseases. Given the complement syste...