University Medical Center Groningen

In situ visualization of autophagy reveals the presence of vesicles at the expanding phagophore rim

The autophagy core machinery mediates the enclosure of cytosolic cargo destined for degradation in the lysosome. The Atg9-Atg2-Atg18 complex coordinates phagophore expansion via directed lipid transfer until closure of the phagophore rim. Using an Atg2 variant (Atg2-PM4) as a mod...

Walking for Chronic Pain: Why It Matters, What We Know and How to Get Started: A Position Paper From the European Pain Federation ( EFIC ) ‘On The Move’ Task Force

ABSTRACT Background Physical activity is a cornerstone of chronic pain management. However, translating general recommendations into practical, clinically meaningful guidance for people living with chronic pain and their healthcare providers remains challenging. Walking represent...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Early Multicentre Outcomes of Endovascular Aortic Arch Repair Using a Custom-Made Triple-Branch NEXUS TRE Endograft System (TRE-ASURE Study)

Objective: To report the first multicentre European experience with the custom-made NEXUS TRE triple-branch endograft for fully endovascular, debranch-free repair of complex aortic arch pathology, focusing on technical feasibility and early safety outcomes. Methods: This retrospe...

Initial Changes in eGFR during Treatment with Balcinrenone and Dapagliflozin

Introduction: The novel non-steroidal mineralocorticoid receptor antagonist balcinrenone in combination with dapagliflozin reduced urinary albumin-to-creatinine ratio (UACR) over 12 weeks in the MIRO-CKD phase 2 trial in chronic kidney disease (CKD) and induced a modest acute eGF...

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

In this study, we demonstrate that during diabetic wound healing, interleukin-11 (IL-11) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro-inflammatory cytokines IL-1β and IL-6. Notably, Rhoifolin (R...

Obesity, incretin-based therapies, and cardiovascular disease in women

Abstract Obesity in women is a growing and multifaceted public health challenge, driven by complex interactions among biological, hormonal, and psychosocial factors across the life course. From menarche to menopause, hormonal fluctuations influence fat distribution, energy balanc...

Reliability, validity, and change over time in disinhibited and disruptive behaviors assessed with the age‐adapted disruptive behavior diagnostic observation schedule in children aged 5–12 years with ADHD

Abstract Background Previous research has shown that the disruptive behavior diagnostic observation schedule (DB‐DOS) is a valid and reliable clinic‐based assessment of disinhibited and disruptive behaviors in preschoolers. We adapted the DB‐DOS for use in children aged 5–12 year...

Long‐Term Outcomes of Omniflow II and BioIntegral Xenografts for Open Aortic Reconstruction in Predominantly Infected Settings: A Multicenter Cohort Study

ABSTRACT Objective Evidence surrounding conduit selection for open in situ aortic reconstruction remains limited particularly for xenograft use in infected settings. We evaluated long‐term outcomes after open aortic and aorto‐iliac reconstruction using BioIntegral No‐React bovine...

Radium-223 decreases PD-L1 expression in bone metastases: A study with [89Zr]Zr-atezolizumab PET and immunohistological correlation

Abstract Purpose Most patients with metastatic castration-resistant prostate cancer (mCRPC) do not benefit from treatment with immune checkpoint inhibitors targeting programmed cell death (ligand) 1 (PD-(L)1). Radiation might improve response to immunotherapy by increasing the im...

Cross-Platform Evaluation Reveals Sample Preparation-Driven Biological Biases despite Advances in Mass Spectrometry Performance in Serum Proteomics

Abstract Advances in mass spectrometry (MS) instrumentation and protein extraction technologies are reshaping proteomics; however, whether improved analytical performance alters the biological information accessible from different sample preparation strategies remains unclear. He...

Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health

Abstract Our Future Health is a prospective study aiming to recruit 5 million UK-resident adults to enable discovery and translation of disease prevention, detection and treatment approaches. So far, more than 2.5 million have enrolled, and baseline phenotypic data are available...

Exploring the transcriptional crosstalk between adipose tissue and locoregional recurrence in breast cancer using independent component analysis

Locoregional recurrence (LRR) poses a persistent clinical challenge in breast cancer, with emerging evidence implicating the tumor-associated adipose tissue in modulating recurrence risk. This study investigates shared transcriptional programs between adipose tissue and breast tu...

Professional identity formation and the limits of intelligibility in medical education: a queer reframing

Abstract Professional identity formation (PIF) has become a central tenet of medical education, yet its dominant assumptions leave a constitutive question underexamined: under what conditions can diverse configurations of knowledge, body, affect, and authority be recognized as le...

An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy

BACKGROUND: Evidence of the diverse genetic architecture of dilated cardiomyopathy (DCM) continues to emerge and requires reassessment of the clinical relevance of implicated disease genes. Building on the 2019-2020 Clinical Genome Resource evaluation, the DCM gene curation exper...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

Gathering input for a mental health intervention based on recovery narratives: a focus group study

Recovery narratives (RNs) could potentially be beneficial for service users, leading to hope and a sense of recognition. It remains understudied how to adequately implement these in mental health treatment. To gather input for the development of a RN intervention, we organized fo...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...