University Hospital Leipzig

Trends in glaucoma diagnosis and medical management in Germany: A nationwide claims data analysis over 10 years

Abstract Purpose Analysing longitudinal trends in recorded diagnosis and medical management of glaucoma in Germany over a 10‐year period. Methods A retrospective cohort study using nationwide outpatient claims and prescription data from the German statutory health insurance syste...

Prognosis of acute symptomatic seizures and impact of prolonged treatment with anti‐seizure medication

Abstract Objectives Acute symptomatic epileptic seizures (ASySs) occur in temporal proximity to acute brain insults. Given their low risk of subsequent unprovoked seizures, current guidelines recommend either no treatment with anti‐seizure medication (ASM) or early discontinuatio...

Oat supplementation alters biochemical and physicochemical properties of gastric digesta – a possible contribution of feeding to gastric diseases in horses

Abstract Equine squamous and glandular gastric disease is highly prevalent and a concern for animal welfare. Biochemical and physicochemical properties of the feed are reflected in those of the digesta, and feeding-related changes in these parameters could play a role in the deve...

From pelvic geometry to modal compliance: sex-specific deformation pathways in the human pelvic ring

Abstract Walking, posture and childbirth all depend on the pelvic ring, yet human pelvic dimorphism is usually interpreted from static birth-canal dimensions. We asked whether sex differences in pelvic function are explained by overall size and static pelvimetry or by available m...

Endothelial metabolism in CDH: mitochondrial dysfunction as a new piece of the puzzle

Congenital diaphragmatic hernia (CDH) remains one of the most challenging developmental lung diseases in neonatal medicine. Despite major advances in prenatal risk stratification, fetal intervention, neonatal intensive care, and extracorporeal support, pulmonary hypoplasia and pu...

OsteoCHAT: real-world patient evaluation and benchmarking of a guideline-grounded osteoporosis chatbot

Patients with osteoporosis have information needs that routine care inconsistently addresses. In this multicenter real-world evaluation, the LLM-based, guideline-grounded chatbot OsteoCHAT showed high participant acceptability and achieved expert-rated answer quality comparable t...

Prevalence and clinical impact of dento-alveolar foci in periprosthetic joint infections: a retrospective cohort study of 213 cases

Abstract Purpose Periprosthetic joint infection (PJI) is a serious complication after total joint arthroplasty, leading to repeated revisions, substantial costs, and increased morbidity. Oral pathologies have been suggested as possible sources of hematogenous infection, however t...

Early prediction of severe morbidity after liver resection using serum albumin and ALBI-score in a mixed patient cohort

Abstract Background Early identification of patients at risk for severe morbidity after liver resection (LR) remains challenging. Serum albumin and albumin–bilirubin (ALBI) score reflect liver function, but their prognostic value in the immediate postoperative period is not well...

CT-derived adrenal-to-spleen ratio as a predictor of massive transfusion and mortality in emergency transcatheter arterial embolization of active bleeding

PURPOSE: In cases of severe shock, the adrenal gland undergoes hyperperfusion to ensure adequate circulation of stress hormones. Concurrently, the spleen experiences hypoperfusion in order to maintain optimal central blood pressure. The objective of this study was to identify the...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Examining Diagnostic Criteria for Atypical Anorexia Nervosa Post Metabolic Bariatric Surgery

ABSTRACT Objective To examine the applicability of current diagnostic criteria for atypical anorexia nervosa (AAN) to patients 1 year post Metabolic Bariatric Surgery (MBS). Method This prospective ongoing cohort study included patients from the multicenter Psychosocial Registry...

Psychotherapy remission prediction models show limited cross-clinic generalizability in routine outpatient care

Abstract Clinical prediction models for psychotherapy outcomes have the potential to assist therapists in planning a patient’s individual treatment, but their clinical utility depends on maintaining predictive performance across settings. We assessed prediction of post-treatment...

Real-world use of bempedoic acid for hypercholesterolaemia: a German multicentre, retrospective, cohort study

Abstract Background Dyslipidaemia remains a leading cause of death in Germany despite an improving therapeutic landscape, with many patients not achieving guideline-recommended low-density lipoprotein cholesterol (LDL-C) goals. Bempedoic acid, an adenosine triphosphate citrate ly...

Outcome‐Guided Immunosuppressive Therapy and Clinical Events in Patients With Cardiac Sarcoidosis: An Observational Registry

Background Immunosuppressive therapy (IST) is commonly used in cardiac sarcoidosis, but the strategy to guide it is unclear and its effectiveness uncertain. We assessed the association between IST, guided by clinical course and positron emission tomography, and clinical outcomes...

Enhanced survival through repeated photodynamic therapy and almost complete tumor regression by prior radiation therapy in an orthotopic rat bladder cancer model

Abstract Introduction The development of new organ-preserving treatment alternatives is still an important issue in bladder cancer (BCa) research. A combination of minimally-invasive photodynamic therapy (PDT) with ionizing radiation (IR) could be beneficial for bladder tumor reg...

Barriers, challenges, and facilitators in oral health care for older adults in home-based care: stakeholder perspectives from germany

Abstract Background With the growing number of people requiring long-term care in Germany, not only is the prevalence of chronic diseases increasing, but oral health is also deteriorating. Many older adults with functional impairments who live at home can no longer maintain their...

Whole-body quantitative muscle MRI in myotonic dystrophy type 2: a sensitive tool for pattern recognition, disease stratification and objective assessment of clinical severity

Background Myotonic dystrophy type 2 (DM2) is a frequent yet underdiagnosed muscle disorder. Although muscle MRI is increasingly used in neuromuscular disorders, there is an overt lack of evidence regarding its role in DM2. This study aimed to characterise whole-body muscle invol...

eGDR and gastrointestinal cancer mortality in the UK Biobank: a prospective cohort study

Abstract Background This study examined the associations of estimated glucose disposal rate (eGDR), a surrogate of insulin sensitivity, and the insulin resistance indices TG/HDL-C and TyG with gastrointestinal (GI) cancer mortality in the UK Biobank. Methods We included 369,447 p...

Anticipating the hospital of the future: stakeholder perspectives on 6G technology requirements in health care

PURPOSE: The ongoing 6G standardization process is largely driven by technical advancements, but with limited consideration of sector-specific needs, particularly in health care. The current scientific literature primarily focuses on technical aspects, offering minimal empirical...

Long-term patient-reported outcomes and quality of life after tibiofemoral knee dislocations in patients with open growth plates: a retrospective case series from a Level 1 trauma center

Abstract Background Tibiofemoral dislocations in children and adolescents are rare, and treatment guidelines are primarily based on adult data and algorithms. This case series of four pediatric and adolescent patients aims to add to the limited literature and highlights key aspec...