Université de Montpellier

Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study

Background: Community-acquired intra-abdominal infections (CA-IAIs) exhibit significant clinical heterogeneity. However, most studies focusing on CA-IAIs do not stratify comparisons by infection site. Methods: This post hoc analysis of the prospective multicenter PERICOM cohort (...

Natural product-derived compounds modulating STAT3 signaling in prostate cancer: Mechanistic insights and therapeutic potential

Prostate cancer (PCa) is a major malignancy in men and current treatment options remain limited by therapeutic resistance and treatment-related toxicity. Signal transducer and activator of transcription 3 (STAT3) is a key regulator of PCa progression and an attractive therapeutic...

Anesthesia TeleConsultation for Pediatric preoperative assessment: a large national prospective multicentric study in children (TeleCCCAP)

Background: While interest in pediatric anesthesia teleconsultation is growing, published data remain scarce. This study evaluated the feasibility of anesthesia teleconsultation in children, providing a comprehensive analysis of failure, quality, dedicated time and satisfaction....

Monoclonal anti-dsRNA antibody-based metagenomics (MADAM) reveal Pyricularia oryzae mycovirome

This study introduces MADAM (Monoclonal Anti-dsRNA Antibody-Based Metagenomics), a novel approach that integrates multiple technical modules previously used independently in other protocols. MADAM combines monoclonal antibody-mediated double-stranded RNA (dsRNA) enrichment, seque...

210Pbex in lacustrine sediments: A half-century global synthesis (1977-2024)

Unsupported 210 Pb ( 210 Pb ex ) is a naturally occurring radionuclide widely used to establish sediment chronologies spanning the past ∼150 years, thereby providing high-resolution temporal frameworks for palaeolimnological reconstructions. Since the late 1970s, numerous hypothe...

Systematic interactome analysis identifies OCRL as a DENV 2 NS4A interactor that inhibits viral replication through a mechanism independent of global actin cytoskeleton rearrangement

Dengue virus (DENV) is a medically important human pathogen belonging to the genus Orthoflavivirus . DENV encodes seven non-structural (NS) proteins which exert multiple cellular effects. NS4A is a 16 kDa membrane-associated protein; however, its functions in orthoflavivirus infe...

Combined Impacts of Climate and Land-Use/Land-Cover Changes on the Flow Regime and Ecological Diversity in the Songkhram River Basin, A Tributary of the Mekong River

Abstract Climate change (CC) and land-use/land-cover (LU/LC) alterations are among the most pervasive drivers of hydrological and ecological change in river basins worldwide, yet their combined impacts on fluvial ecological diversity remain insufficiently quantified, particularly...

Environmental and demographic determinants of Aedes albopictus seasonal activity in southern France: A modeling study

The presence and the activity of Aedes albopictus are a growing concern for nuisance and public health in Europe. Despite an increasing number of entomological and modelling studies, our incomplete understanding of mosquito population response to weather drivers in natural condit...

Combined Idiopathic Intracranial Hypertension score, an integrated severity and treatment-oriented tool for idiopathic intracranial hypertension: a retrospective cohort study

IIH has evolved into a multidisciplinary condition managed across neurology, ophthalmology, interventional neuroradiology, and surgery. Existing tools address only partial aspects of disease severity; no unified, treatment-oriented classification exists to support multidisciplina...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Complex non-falciparum transmission and widespread insecticide resistance sustain hyperendemic malaria in Penka-Michel, a focus of the Cameroon highlands

A 12-month longitudinal entomological study (September 2023-August 2024) in the Western Highlands of Cameroon (Penka-Michel) investigated malaria transmission dynamics and insecticide resistance markers, including target-site resistance (L1014F, N1575Y, G119S- Ace1 ) and metaboli...

Integrating Next-Generation Reproductive Organoids with Genomics, Multi-Omics and Bioengineering to Understand Human Infertility

Infertility affects approximately one in six individuals worldwide and is a highly heterogeneous disorder resulting from the complex interplay of genetic, epigenetic, endocrine, environmental and lifestyle factors. Although numerous genes and molecular pathways involved in female...

Government shutdowns and consumer confidence: evidence from US news coverage and Google Trends

Purpose This study examines the effect of US government shutdowns on consumer confidence and investigates the potential transmission roles of economic policy uncertainty, equity market volatility and global supply chain pressure. Design/methodology/approach Using monthly US data...

Revealing archaeological olive diversity: insights from stone geometric morphometrics, experimental charring, and varietal identification (Port-la-Nautique, France, Roman period)

The cultivated olive tree, domesticated in the Levant by the mid-5th millennium BCE, spread westward across the Mediterranean to reach southern France by 600 BCE. Although geometric morphometrics applied to archaeological olive stones has provided insights into this diffusion, mo...

OpenAlea.HydroRoot: A modelling framework to dissect, predict and phenotype branched root hydraulic architecture

Abstract Drought is a significant factor in agricultural losses, making it imperative to understand how root system architecture (RSA) adapts to environmental condition like water deficit. HydroRoot is a functional-structural plant model (FSPM) aimed at analyzing and simulating h...

Changes in LVOT velocity–time integral during whole blood donation: implications for early detection of hypovolemia in spontaneously breathing patients

Early identification of hypovolemia remains challenging in emergency settings, as vital signs may remain normal during initial blood loss. Point-of-care echocardiography allows assessment of stroke volume through left ventricular outflow tract velocity–time integral (LVOT VTI), b...

Personalized FES-cycling patterns via optimal control: from musculoskeletal simulation to experimental validation

This study introduces an optimal control framework for functional electrical stimulation (FES) cycling that produces personalized stimulation patterns directly transferable from simulation to experimental cycling, without the need for empirical tuning. We use a physiological musc...

Hydraulic function of medullary bundles in a tropical root climber

Abstract Premise Medullary bundles, which are vascular bundles in the pith, have evolved multiple times. However, their functional significance remains poorly understood. Here, we investigated how medullary bundles are involved in the vascular architecture and hydraulic function...

Multiomics reprogramming reverses disease susceptibility in Magallana gigas during aging

Aging is a progressive and irreversible biological process that typically increases susceptibility to infectious diseases. However, unexpectedly, the opposite outcome was observed in oysters: older oysters exhibit increased tolerance to Pacific oyster mortality syndrome (POMS), a...

Statistical discrimination of Guatemalan jadeitite sources using LA-ICP-MS trace element and petrological data

While tracing the geological provenance of Maya jadeitite-jade is key to understanding Mesoamerican exchange and extraction, distinguishing between the north (NMM) and south (SMM) Motagua sources presents significant challenges. This difficulty is due to shared mineralogical trai...