Université de Montpellier

Can machine learning be used to quantify blood loss based on hemodynamic data? Experimental study of controlled hemorrhagic shock in anesthetized piglets

Background Hemorrhagic compensatory physiological mechanisms may initially lead to an underestimation of the severity of a hemorrhage, for which quantification of blood lost volume is difficult. The objective of our study was to assess the suitability of machine learning (ML) to...

Wings act as a solar shield against solar radiation in the desert locust, Schistocerca gregaria

Morphological traits in insects have frequently evolved multifunctional roles, including contributions to thermoregulation. Wings typically function in flight, but may also provide protection against intense solar radiation. In the desert locust, Schistocerca gregaria , males are...

Questioning the G2 phase in the budding yeast cell cycle with a qualitative and possibilistic model

Abstract The budding yeast S. cerevisiae , a foundational model for cell cycle studies, exhibits a complex phase organisation (G1, S, G2/M) governed by checkpoints ensuring faithful cellular inheritance. However, the existence of a distinct G2 phase in yeast remains debated, with...

Reimpregnation of Disordered Mesopores by Ionic Liquids

Abstract The reimpregnation, i.e., replacement of the soft-templating ionic liquid (IL, BMIM-TFSI) that forms the porosity during the synthesis of disordered mesoporous silica-based (ionosilica) materials, has been studied by an original combination of small-angle X-ray scatterin...

Half-Flips are 5-Avoidable

A word contains a half-flip if it contains non-empty factors [Formula: see text] and [Formula: see text] where [Formula: see text]. Fici reports a non-constructive proof of the existence of an infinite word over a finite alphabet avoiding half-flips and asks for the size of the s...

Change in the demographic dynamics of a spatially structured population of a colonial waterbird after a perturbation affecting a large colony

Localized perturbations may affect spatially structured populations (SSPs) as a whole by altering dispersal between patches. Yet, such large-scale consequences remain poorly understood and may depend on the proportion of the SSP affected by the perturbation. Here, we used correla...

Evaluating the roles of testosterone and sex-linked genes in territorial aggression of sex-reversed XY females in the African pygmy mouse

Sex differences in social aggression are widespread across the animal kingdom, with males typic-ally displaying greater territoriality. While this dimorphism has traditionally been attributed to sex hormones, sex chromosomes can also contribute to it independently of hormonal inf...

Estimating relapse time distribution from longitudinal biomarker trajectories using iterative regression and continuous time Markov processes

Abstract Biomarker measurements obtained by blood sampling are often used as a non-invasive means of monitoring tumour progression in cancer patients. Diseases evolve dynamically over time, and studying longitudinal observations of specific biomarkers can help to understand patie...

Accurately Probing [Fe(CN)6] Defects in Prussian Blue Analogues

Abstract Prussian blue analogues AxM[Fe(CN)6]1–y·zH2O (A = Na, K, M = Fe, Mn) possess a rich crystal chemistry that allows their use as insertion materials for batteries, water treatment, and smart windows, among others, applications. Despite being simple in appearance, their syn...

Association between the site of emergency care and patient-centered outcomes in patients with cancer: rationale and design of the French COVER cohort

Patients living with cancer now account for a substantial and growing share of emergency department (ED) visits and carry a high burden of hospitalization and in-hospital death. Their acute presentations are frequently multifactorial - driven by disease progression, treatment tox...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Association Between a 3D ‐Printed Simulation Model and Self‐Assessed Confidence in Dental Trauma Management

ABSTRACT Introduction and Aim Simulation‐based learning using 3D‐printed models offers a promising approach to improve confidence in complex procedures. Dental trauma can lead to severe functional and esthetic consequences if not managed promptly and effectively. This study aimed...

Low-level of mitochondrial DNA alterations during direct-acting antiviral treatment in leukocytes of people who inject drugs living with HCV

Direct-acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, offering high cure rates and favorable safety profiles. However, concerns remain regarding their long-term mitochondrial safety, particularly among vulnerable populations such as people who inj...

A multiregional serosurvey of RNA virus-reactive antibodies in bats and rodents reveals the enzootic presence of flavi- and paramyxoviruses in African Pteropodidae

Bats and rodents have been identified as reservoir hosts of diverse RNA viruses that pose potential risks to humans. However, overall virus prevalence in wildlife and underlying factors determining the zoonotic potential of reservoir-borne viruses remain poorly characterized. Vir...

Replicability of agent-based simulations: a case study with a SEIRS epidemiological model

Reproducibility is not only a cornerstone of the advancement of science, but also of scientific credibility. However, it remains a persistent challenge across many disciplines, and it is now referred to as the “reproducibility crisis.” This issue is particularly relevant in compu...

Few-shot learning for expert consensus severity stratification in newly diagnosed crohn’s disease

Early and accurate assessment of disease severity is important for standardizing baseline risk stratification and supporting treatment planning in newly diagnosed Crohn’s disease. This study used electronic medical record data, a few-shot learning algorithm, and SHAP-based interp...

Post-Nap Sleep Inertia in Narcolepsy Type 1 and Idiopathic Hypersomnia

Abstract Study objectives To compare post-nap sleep inertia between patients with idiopathic hypersomnia (IH) and narcolepsy type 1 (NT1) by assessing changes in subjective sleepiness and objective performance. Methods In 128 drug-free patients (50 IH, 78 NT1), standardized overn...

The geometry of gametic dispersal in a flying mammal, Rhinolophus hipposideros

Abstract Dispersal influences population and evolutionary dynamics, in a manner that depends on by which dispersal strategies gene flow occurs. In some species, mating partners move exclusively for mating, dispersing genes but not individuals. This is the case in many bat species...

Beyond correlation: Intraclass correlation and bland-altman analysis reveal poor absolute agreement across multiplex cytokine immunoassay platforms

Cross-platform comparisons of serum cytokine immunoassays have often focused on rank correlation, but the extent of absolute agreement and systematic bias between platforms remains insufficiently characterized. Few independent head-to-head evaluations have compared multiple immun...

First-Principles Simulation of Ionizing Radiation Damage in Molecular Systems over Short Time Scales

Abstract In this work, we present an ab initio molecular simulation method designed to investigate the ultrashort time scales of radiation chemistry induced by ionizing radiation, in particular fast ions and electric pulses. The approach accounts for energy deposition at the subf...