Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

In-depth characterisation of the tumour microenvironment reveals HHV-8-dependent immune regulation in HIV-associated and classic Kaposi sarcoma

BACKGROUND: Kaposi's sarcoma (KS) is the most common malignancy occurring in people living with HIV (PLWH). The clinical course of KS in PLWH established on combined anti-retroviral therapy (cART) resembles that of classic KS. OBJECTIVES: To compare the clinical and biological ch...

Does an Unconventional Source with a High Silica Content (Obsidian) or a High Alumina Content (Bauxite) Affect the Type of Potassium Zeolite Formation? Preliminary Data on Synthetic Products’ Efficiency in Ammonium Removal

In this paper, obsidian (OS) and bauxite (BX) are used to synthesize zeolites via KOH prefusion, followed by a conventional hydrothermal process (HY) or an unconventional vapor-phase crystallization method (VPC) at 90 °C. The results indicate that, due to their chemical and miner...

Development a novel in silico mRNA vaccine against Clostridium difficile

Clostridium difficile , a toxin-producing bacterium, can lead to conditions ranging from mild diarrhea to severe pseudomembranous colitis. Our research introduces an innovative strategy for developing a multi-epitope mRNA vaccine using in-silico methods targeting proteins involve...

A Sequential Gut–Pancreas–Liver In Vitro Model to Evaluate the Multi-Target Metabolic Effects of a Nutraceutical Formulation in MASLD-Related Conditions

Background/Objectives: Metabolically dysregulated-associated steatotic liver disease (MASLD) is a complex, multifactorial disorder characterised by hepatic lipid accumulation, insulin resistance, oxidative stress, and dysfunction of the gut–liver axis. Given its intricate pathoph...

Socioeconomic and Linguistic Factors in Paediatric Type 1 Diabetes: Exploring Glycemic Outcomes, Technology Use, and Residual Beta‐Cell Function in Migrant‐Background Populations

ABSTRACT Aims To investigate associations between migrant status, socioeconomic factors (SES), and residual beta‐cell function and glycemic outcomes in paediatric type 1 diabetes. Methods Retrospective study of 208 children (median [IQR] age 11 [8–14] years; 119 Italian, 89 from...