Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

Development of N -Hydroxyindole-2-Carboxamides as New Host-Targeted Broad-Spectrum Antiviral Agents Against Human Respiratory Viruses

Abstract Endoplasmic reticulum (ER) oxidoreductases are promising targets for host-targeted antiviral agents (HTAs) because of their essential role in protein folding, including the maturation of viral proteins. Human protein disulfide isomerase family member A3 (PDIA3) is involv...

Botulinum Toxin for Temporomandibular Disorder: Current Evidence, Clinical Applications, and Future Perspectives

Temporomandibular disorders (TMDs) are heterogeneous musculoskeletal conditions frequently characterized by pain, impaired mandibular function, and reduced quality of life. Botulinum neurotoxin type A (BoNT-A) has emerged as a potential therapeutic option, particularly for persis...

Real-world adjunctive use of an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes in drug-resistant epilepsy: the multicentre retrospective ARMILLA study

The purpose of this study was to describe real-world adjunctive use, tolerability, and hypothesis-generating seizure and multidomain outcomes of LALBAAY, an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes (FSMP), in patients with drug-resistant epilepsy (DRE)....

Ligand Engineering Controls Near-Infrared Emission, Quantum Efficiency, and Photoluminescence Lifetimes in Dimetallic Ru(II) Complexes

Abstract The exceptional photophysical and electrochemical properties of Ru(II) complexes support broad applications in optoelectronic functional materials and bioimaging, particularly those Ru(II) complexes which show near-infrared (NIR) luminescence. This study reports ligands...

Selective immunoglobulin A deficiency and coeliac disease: Immune response dynamics

Abstract Objective To analyse the serological immune response in paediatric patients with selective immunoglobulin A deficiency (SIgAD) and coeliac disease (CeD), focusing on immunoglobulin G antibody dynamics after starting the gluten‐free diet (GFD). Methods Data from SIgAD pat...

Activities and Role Perceptions of Clinical Research Nurses in Participating Italian Scientific Research Hospitals: A Multicentre Cross-Sectional Survey

Background/Objective: Clinical research nurses (CRNs) support participant care and trial conduct, yet their role is inconsistently recognised and integrated in Italian Scientific Institutes for Research, Hospitalisation and Healthcare (IRCCSs). This study aimed to describe the pe...

Incidence, predictors, and population attributable fraction of hypertension among adults with diabetes mellitus in North Gondar Zone, Ethiopia: a retrospective cohort study

Hypertension is a common and serious complication of diabetes mellitus caused by metabolic and vascular changes that increase peripheral vascular resistance, raising the risk of cardiovascular disease, chronic kidney disease, and premature mortality. However, evidence on its inci...

Longitudinal health-related quality of life after electrochemotherapy in elderly patients with cutaneous melanoma

The incidence of cutaneous melanoma (CM) is increasing among elderly patients, who often present with advanced disease, including cutaneous metastases. Electrochemotherapy (ECT) is a local ablative treatment that enhances chemotherapy uptake via electric pulses. Management in pat...

The Archling Condition

Conservation biology has a name for the absences left by extinction: ghosts of the past, species and ecological relationships that persist as vestiges after their bearers are gone. Advances in synthetic biology are producing an inverse figure that has received little philosophica...

Open source deep learning models for accurate fastener defect inspection

Abstract In fastener production, ensuring consistent product quality is essential to protect the safety and performance of components used in demanding applications. Although mechanical sorting equipment and early generations of machine-vision technology have successfully handled...

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...

Salivary hormones and adipokines are associated with glycemic control and early renal and cardiometabolic markers in children and young adults with type 1 diabetes

Abstract Purpose Type 1 diabetes (T1D) is recognized as a complex metabolic condition associated with hormonal dysregulation and early complications. This study aimed to evaluate salivary metabolic hormones and adipokines in children and young adults with T1D, and to assess their...

Perceptions and attitudes toward patient safety: perspectives of students in the medical and health sciences at the University of Aden, Yemen

Abstract Background Patient safety competencies remain insufficient among health sciences graduates, especially in conflict-affected areas. This study assessed perceptions and attitudes toward patient safety among undergraduate medical students at the University of Aden, Yemen. M...

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition

Abstract In bacteria, DnaB replicative helicases are essential for unwinding genomic DNA to provide the single‐stranded templates required for replication. The recruitment of the hexameric DnaB helicase to the origin of replication is mediated by distinct mechanisms that rely on...

The effect of combined lifestyle intervention among long term care facilities: A systematic review

The purpose of this research: Population aging is one of the most significant demographic phenomena of the 21st century. It has led to a growing number of older adults requiring long-term care (LTC), which poses significant challenges for healthcare systems worldwide. Lifestyle m...

Incidence and Risk Factors of Unplanned Emergency Department Transfers From Italian Nursing Homes: A Prospective Multicentre Cohort Study

ABSTRACT Aim To estimate the incidence of unplanned transfers to the emergency department among nursing home residents and to identify resident and organizational factors associated with transfer risk. Design A 12‐month prospective multicentre dynamic cohort study. Methods The st...

Continuous Glucose Monitoring and Automated Insulin Delivery in Infants with Type 1 Diabetes: Real-World Evidence to Support Future International Guidelines

To evaluate efficacy and safety of continuous glucose monitoring (CGM) and automated insulin delivery (AID) in infants. A retrospective multicenter study (13 centers) of 76 children diagnosed with antibody-positive type 1 diabetes before age 2. Outcomes at 12 months were compared...

Multidisciplinary Delphi consensus-based recommendations on the use of image-guided radiotherapy for upper gastrointestinal tumours: an AIRO–AITRO–AIFM study

Abstract Objectives Upper gastrointestinal (GI) malignancies represent one of the most challenging scenarios for image-guided radiotherapy (IGRT). Despite technological advances, clinical practice remains heterogeneous among centres. This national, multidisciplinary Delphi consen...

Prospective analysis of pre-diagnostic untargeted plasma metabolomics and risk of triple-negative breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...