Università Cattolica del Sacro Cuore

Scaling of an evidence-based intervention program in older people with diabetes and frailty in Latin America. Diabfrail-Latam clinical trial protocol

Objectives Diabfrail-Latam is a project funded by the Horizon 2020 program of the European Commission (EC) and the Global Alliance for Chronic Diseases (GACD). The main objective of this protocol is to describe the clinical validation of a multimodal intervention aimed at older p...

Biological aging for the advancement of biogerontology: Between hopes and hypes

Population aging has intensified the search for biological measures that can explain why individuals of the same chronological age differ so markedly in health, function, resilience, and disease burden. Geroscience has provided a powerful framework by linking shared mechanisms of...

Large-scale electrophysiological signatures of Williams syndrome: evidence from oscillatory power and brain fluidity

Evidence suggests that Williams syndrome (WS) may be associated with atypical cortical oscillatory activity and large-scale structural and functional anomalies. However, links between whole-brain electrophysiological measures and cognitive performance in WS remain scarce. This st...

Artificial Intelligence and Sensing Technologies for Vascular Access in Hemodialysis: A Narrative Review

Vascular access performance determines the adequacy, safety, and cost of hemodialysis. Stenosis, thrombosis, cannulation difficulty, infection, and access-related cardiac stress remain major sources of morbidity. This narrative review examines artificial intelligence and sensing...

A Mechanistic Framework for Somatic Mosaicism in Autoinflammatory Diseases Beyond Mendelian Inheritance

Hereditary autoinflammatory diseases have traditionally been defined as disorders caused by germline mutations in innate immune pathway genes transmitted through Mendelian inheritance, an assumption challenged by the discovery that postzygotic somatic mosaicism can reproduce simi...

Quantitative and exact concavity principles for parabolic and elliptic equations

Abstract Goal of this paper is to study classes of Cauchy–Dirichlet problems which include parabolic equations of the type \begin{equation*}u_t -\Delta u= a(x,t)f(u)\quad\hbox{in}\ \Omega\times(0,T)\end{equation*} u t − Δ u = a ( x , t ) f ( u ) in Ω × ( 0 , T ) with upper Omega...

Is there a new ‘right to Milan’? Neo-normative control and spacing practices in post-pandemic corporate spaces

In this study, we examine the spacing practices through which neo-normative control is both preserved and contested via organizational spatial renovations, focusing on the post-pandemic context of Milanese corporations. Between 2022 and early 2024, we collected field-level data f...

Outcomes and adverse events of postoperative stereotactic interventional radiotherapy/brachytherapy for brain metastases: a systematic review

Postoperative radiotherapy is commonly used after resection of brain metastases, but durable local control with a low rate of adverse events (AEs) remains challenging. This systematic review summarizes outcomes and AEs of postoperative stereotactic interventional radiotherapy (S-...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...

Clinical efficacy/effectiveness, safety, and health-related quality of life associated with relapsed/refractory pediatric low-grade glioma treatments: systematic literature review

Abstract Background Patients with relapsed/refractory pediatric low-grade glioma (R/R pLGG) face considerable long-term morbidity. Most cases are driven by mitogen-activated protein kinase (MAPK) pathway alterations, for which several targeted agents have been evaluated. Systemat...

Anchoring Trust. Order of moves and agent behavior in two Trust Games

Abstract The paper reports and discusses the results of a randomized experiment testing whether the order of moves in two subsequent Trust Games, with reversed roles, affects the level of trust, measured by the share of their endowment that Trustors send to Trustees. We find that...

Establishment and characterization of primary retinoblastoma cell lines: a comprehensive molecular profiling approach

Retinoblastoma (RB) research is significantly constrained by the limited availability of preclinical models that accurately recapitulate the disease complexity, particularly regarding the context of vitreous seeding, a major driver of therapeutic resistance and treatment failure....

HPV DNA Detection and Genotyping in Basal-Like Breast Carcinoma: Insights into a Possible Viral Association

Objectives: High-risk human papillomavirus (HPV) has been implicated in breast carcinogenesis, but its role remains controversial. Basal-like breast carcinomas (BLCs) share morphological and immunophenotypic features with HPV-related squamous cell cancers. This study aimed to det...

Atomic force microscopy in human post-mortem samples: current applications and future directions

Abstract Nanotechnologies are increasingly being explored in forensic science, including Atomic Force Microscopy (AFM), a scanning probe technique capable of high-resolution surface analysis and quantitative nano-mechanical assessment. AFM can be applied to both inert materials a...

Digital and computational morphology in hematology: current platforms, clinical evidence, and future requirements

INTRODUCTION: Morphologic examination of peripheral blood and bone marrow remains central to the diagnosis and classification of hematologic disorders. Conventional optical microscopy, however, is labor-intensive, dependent on operator expertise, and affected by interobserver var...

Lifelong Genetic Inhibition of PCSK9 and Hepatic Safety

This genetic association study investigates whether the full spectrum of rare PCSK9 loss-of-function variants is associated with incident liver-related outcomes, given the development of therapies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9).

HIV and anticholinergic burden: Towards a pragmatic stewardship algorithm

Abstract Background Multimorbidity and polypharmacy increase exposure to medications with anticholinergic properties in people with HIV. In elderly people, higher anticholinergic burden (ACB) is linked to cognitive impairment, falls, functional decline and mortality, whose risk i...

Key Issues and Factors Affecting the Sustainable Development Goals: A Systematic Review and Thematic Synthesis

The Sustainable Development Goals (SDGs) constitute an integrated framework for global sustainability, yet progress remains inconsistent across regions and indicators four years before 2030. Identifying the key issues and factors that influence SDG performance is therefore essent...

Epiretinal Human Amniotic Membrane Overlay for Recurrent Retinal Detachment in Highly Myopic Eyes with Peripapillary Breaks over Chorioretinal Atrophy: Surgical Technique and Outcomes

Purpose: To evaluate the anatomical and functional outcomes of an epiretinal cryopreserved human amniotic membrane (hAM) overlay technique for the management of recurrent retinal detachment (RD) associated with peripapillary breaks in highly myopic eyes. Methods: Retrospective in...

Myalgic encephalomyelitis/chronic fatigue syndrome and overlapping post-acute infection syndromes: international expert consensus framework for diagnostic standardization

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) lacks validated objective diagnostic criteria, leading to delayed diagnosis and inconsistent management. We aimed to establish an international expert consensus framework integrating measurable, risk-stratified assessmen...