Università Cattolica del Sacro Cuore

Predicting the risk of dehydration and readmission among rectal cancer patients with ileostomy: a multicenter observational study

Abstract Dehydration is a frequent complication among rectal cancer patients after ileostomy, often resulting in hospital readmission. The Dehydration Readmission after Ileostomy Prediction (DRIP) score was used to identify patients at risk of dehydration-related readmission. The...

The diminishing polyads of parenting: exploring cultural perspectives of ‘good parenting' using grounded theory analysis

Introduction This study investigates Italian parents' perceptions of ‘good parenting' and cultural variations. 250 mothers and 87 fathers were surveyed during the third trimester, with follow-ups at 6–12 weeks and 6 months postpartum. Methods Using Grounded Theory Analysis, data...

Precision without participation: why precision psychiatry needs Collaborative/Therapeutic Assessment

Contemporary psychiatry often assumes that more precise diagnosis will yield more effective care. Biomarkers, digital phenotyping, artificial intelligence and related tools promise better diagnosis, treatment selection and outcomes. Yet this expectation is clinically incomplete:...

Lean Mass Reduction During Glucagon-like Peptide-1 Receptor Agonists-Induced Weight Loss: Rethinking Its Clinical Significance

The substantial weight loss achieved with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual incretin agonists has transformed the management of obesity and cardiometabolic risk. However, the accompanying reduction in lean mass has raised concerns regarding potential...

Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases

Abstract Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment of hematological malignancies, yet its broader application to solid tumors, chronic viral infections, and autoimmune diseases remains constrained by antigen heterogeneity, immunosuppressive tiss...

Long‐Term Care of OLP Patients: A Retrospective Study From a Single Hospital Outpatient Clinic

ABSTRACT Background Oral lichen planus (OLP) is a chronic immune‐mediated disorder with malignant potential. However, its real‐world clinical course remains incompletely characterized. This study aimed to describe the natural clinical–histopathological trajectory of OLP in a sing...

Implementing liquid biopsy in HR+/HER2− metastatic breast cancer: challenges and opportunities

PURPOSE OF REVIEW: Liquid biopsy (LB) is rapidly transforming the management of hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer (mBC). In this review, we discuss the most recent findings on circulating tumor DNA (ctDNA) and circulating tumor cells (CT...

Turning social concerns into entrepreneurial intentions: unpacking the role of social entrepreneurship in emerging economies

Purpose This study examines how social entrepreneurship influences social entrepreneurial intentions among university students in a developing economy. It explores the sequential mediating roles of entrepreneurial attitude and entrepreneurial motivation, as well as the moderating...

Transcriptomic profile and endothelial changes during differentiation syndrome in acute promyelocytic leukemia

Abstract Acute promyelocytic leukemia (APL) is curable with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), but differentiation syndrome (DS) remains a potentially life-threatening complication, with poorly understood pathogenesis. We investigated clinical, molecular a...

Seminal Biomarkers and Sperm Proteomic Signatures Differentiate Acute and Chronic Male Accessory Gland Inflammation

BACKGROUND: Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)-defined MAGI phenotypes correspond to dis...

Cemiplimab in cutaneous squamous cell carcinoma: a longer follow‐up study focusing on the late toxicities

Summary Background and Objectives Cemiplimab was the first systemic therapy approved for advanced cutaneous squamous cell carcinoma (cSCC). Patients and Methods We report findings from the Italian early access program cohort, comprising 134 patients treated with cemiplimab, with...

A Randomized Controlled Trial Evaluating Negative Pressure Therapy (NPT) to Reduce Wound Complications Following Major Lower Extremity Amputation

Objective: This study hypothesizes that negative pressure therapy (NPT) reduces wound-healing complications following major amputation. Background: Major lower extremity amputation carries a high incidence of incisional complications. NPT reduces these complications in other area...

Soft tissue sarcomas prognosis based on clinical-pathological profile: a retrospective population-based study

Soft tissue sarcomas (STSs) account for less than 1% of adult cancers and encompass a diverse range of neoplastic diseases. This population-based study evaluates the five-year overall survival rates of a cohort of STS patients. The study examined 325 incident cases of nonmetastat...

Tryptophan Metabolism in Digestive and Extra-Digestive Diseases: Mechanisms, Clinical Implications, and Therapeutic Perspectives

Tryptophan (Trp) metabolism lies at the intersection of nutrition, gut microbiota, mucosal immunology, and systemic inflammation—processes that play key roles in many gastrointestinal and extraintestinal diseases. Trp is an essential amino acid obtained through dietary intake. Be...

Digital practices in CLIL across Romance- and Germanic-language contexts: a teacher survey with complementary student data

Research on digital practices has grown substantially thanks to recent technological advancements. Using data from the COST Action CA21114 Digital Literacies Teacher Survey (DLTS) and Student Survey (DLSS), where Content and Language Integrated Learning (CLIL) classrooms are focu...

Impact of low-dose epidural analgesia on labour progression in Robson Classification Group 1 parturients: a single-centre retrospective observational study

The influence of epidural analgesia (EA) on the course of labour is still a matter of concern in modern obstetrics. Despite numerous studies have analysed labour progression, their findings are often inconsistent with regard to the effect of labour analgesia. In fact, women with...

Metabolic Dysfunction–Associated Steatotic Liver Disease: An Underrated and Emerging Cardiovascular Risk Factor

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and is increasingly recognized as a major contributor to cardiovascular morbidity and mortality. Beyond liver involvement, MASLD represents a systemic metabolic...

Auriculotherapy for controlled hypotension during functional endoscopic surgery of the paranasal sinuses under general anesthesia: AuriFESS, a feasibility randomized pilot study

Abstract Background Administration of hypotensive drugs is common to induce controlled hypotension during surgery but dose-dependent side effects could limit their use. The primary hypothesis of our study is that the application of magnetic ball-plasters for auriculotherapy could...

Expert Consensus Develops Multidisciplinary Pathway for Cancer Pain Management in Italy: A Delphi Study

Background: Cancer pain remains highly prevalent and undertreated despite established guidelines. In Italy, Law 38/2010 mandates systematic pain assessment, yet only 26% of clinicians routinely evaluate pain at each clinical visit, and fewer than one-quarter have received formal...

Percutaneous Retrograde Intramuscular Echo-Guided Fat Grafting (PRIME-GRAFT): A Novel Technique to Increase Safety and Improve Results

Summary: Achieving natural and dynamic body definition remains a challenge in body contouring surgery. High-definition lipoplasty has enhanced aesthetic outcomes by sculpting the superficial fat layer, and intramuscular fat grafting (IFG) has been used to improve muscle volumizat...