Università Campus Bio-Medico

The Efficacy of Locoregional Anesthesia on Postoperative Pain After Spine Surgery

Study Design: Systematic review and meta-analysis. Summary of Background Data: Postoperative pain management in spine surgery remains a significant challenge, often involving general anesthesia (GA) and associated complications. Locoregional anesthesia (LRA) has gained attention...

A predictive coding framework for safe and versatile control of supernumerary robotic limbs

Supernumerary robotic limbs (SLs) have the potential to extend human sensorimotor capabilities by increasing effective degrees of freedom. However, current systems are designed for a single task and cannot flexibly coordinate with natural limbs (NLs). Here we propose a hierarchic...

Benchmarking foundation models for tumor segmentation across multiple cancer types

Abstract Tumor segmentation is a core task in medical image analysis, with direct implications for diagnosis, treatment planning, and disease monitoring. Whether promptable foundation models are mature enough for heterogeneous oncological scenarios remains an open question. We pr...

Ultrasound‐Based Skeletal Muscle Assessment for Prognostication in Cirrhosis: A Systematic Review

BACKGROUND AND AIMS: Sarcopenia is a major determinant of adverse outcomes in cirrhosis, yet CT- and MRI-based assessments are difficult to implement in routine and longitudinal practice. Ultrasound is a feasible bedside alternative, but its prognostic role remains unclear. We pe...

Real-world effectiveness and drug retention rate of risankizumab in patients with psoriatic arthritis: data from the multicentre GIRRCS cohort

Introduction Psoriatic arthritis (PsA) is a chronic heterogenous inflammatory disease characterized by a multidomain burden. Risankizumab, a selective inhibitor of the IL-23 p19 subunit, has shown efficacy in randomized trials; however, real-world data in PsA remain limited. We e...

Molecular Pathogenesis, Global Epidemiological Trends, and Treatment Strategies for Pteropine Orthoreoviruses: A Narrative Review

Pteropine orthoreoviruses are emerging bat-borne zoonotic viruses of the genus Orthoreovirus (family Reoviridae), increasingly recognized as causes of acute respiratory disease in humans. Originally grouped with the largely non-pathogenic mammalian orthoreoviruses, they have chal...

Arbovirus co-circulation and epidemiological convergence in a changing climate: challenges for surveillance, diagnosis and public health preparedness

Abstract Arboviral diseases are undergoing substantial epidemiological changes driven by climate change, urbanization, global mobility, vector expansion, and evolving ecological conditions. These processes increasingly favor the geographic overlap and co-circulation of multiple a...

Quantum-enhanced hybrid-model compression using knowledge distillation

Abstract Quantum computing has emerged as a promising paradigm for addressing computational tasks intractable for classical systems, leveraging quantum mechanical principles such as superposition and entanglement to efficiently explore high-dimensional solution spaces. In recent...

Current cybersecurity threats to patient safety in the operating room: a review

Abstract Surgical, anesthetic, and intensive care practices now depend on a large ecosystem of wired and wireless devices, robotic consoles, imaging and laboratory systems, and cloud infrastructure: the Internet of Medical Things and the smart operating room, which extends care b...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

ABSTRACT Understanding how peripheral sensory circuits encode mechanical and thermal stimuli requires an experimental system that combines native tissue architecture with high‐resolution electrophysiological readouts. Existing innervated in vitro skin models typically rely on che...

Multidisciplinary Delphi consensus-based recommendations on the use of image-guided radiotherapy for upper gastrointestinal tumours: an AIRO–AITRO–AIFM study

Abstract Objectives Upper gastrointestinal (GI) malignancies represent one of the most challenging scenarios for image-guided radiotherapy (IGRT). Despite technological advances, clinical practice remains heterogeneous among centres. This national, multidisciplinary Delphi consen...

Ultrasound-Guided Retroperitoneoscopic Lumbar Sympathetic Chain Selective Clamping with Indocyanine Green-Assisted Access: A Technical Note

Background: Primary plantar hyperhidrosis is a disabling condition characterized by excessive plantar sweating and impaired quality of life. Lumbar sympathectomy is reserved for patients with symptoms refractory to conservative treatment, but minimally invasive techniques remain...

Semi-inlay and onlay humeral stems in reverse shoulder arthroplasty achieve comparable outcomes through different patterns of glenoid and humeral lateralization and distalization: A retrospective study from the FP-UCBM Shoulder Study Group

Background Reverse shoulder arthroplasty (RSA) has evolved through different humeral stem designs to optimize biomechanics and minimize complications. Although inlay and onlay configurations differ in geometry and bone preservation, their clinical outcomes often appear similar. T...