Università Campus Bio-Medico

Structural determinants of communicable disease risk in asylum reception centres

Introduction With over 120 million people forcibly displaced globally, asylum reception systems represent critical epidemiological interfaces. This synthesis is not confined to a single geographic region: evidence was drawn from reception systems across high-income host countries...

Effect of lumbar strengthening exercises on kinesiophobia in people with chronic low back pain: a systematic review

Kinesiophobia is a key psychological factor in CLBP and represents a significant barrier to functional recovery. Strength exercises are commonly recommended for CLBP, yet their specific impact on kinesiophobia remains unknown. A systematic review was conducted to evaluate the eff...

A Physical Therapy Clinical Framework for Temporomandibular Disorders: Integrating DC/TMD, ICOP and Multidimensional Patient Phenotyping

Temporomandibular disorders (TMDs) are clinically heterogeneous, and patients sharing the same diagnosis may differ substantially in pain mechanisms, functional impairments, behavioral contributors, comorbidities, psychosocial burden, prognosis, and treatment response. Although t...

Training the Next Generation of Future Surgical Residents: A Scoping Review and Proposal for an Undergraduate Curriculum From the Italian Polispecialistic Society of Young Surgeons

AIM: The transition from medical school to surgical residency is marked by a persistent gap between theoretical instruction and clinical readiness. In Italy, variability in training programs across centers creates persistent gaps in residents’ medical education. Scientific societ...

A Computational Workflow Integrating Explainable AI and Database Mining for the Prioritization of Antimicrobial Natural Products

The escalating threat of antimicrobial resistance demands the discovery of antibacterial agents with unprecedented chemical scaffolds. Natural products have historically been the most prolific source of antibiotics, yet the vast majority of catalogued natural products remain unte...

Surveillance, Detection and Therapeutic Innovation in Antimicrobial Resistance in the Age of Polycrisis: From Genomic and Digital Innovation to One Health Integration

Antimicrobial resistance (AMR) surveillance is increasingly strained by interconnected global crises, i.e., pandemics, climate change, armed conflicts, population mobility, and health inequalities, that disrupt healthcare delivery, diagnostic capacity, and laboratory infrastructu...

Impact of GLP-1 Receptor Agonists on Cognitive Performance in Adults at Risk of Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background/Objectives: Type 2 diabetes, a widely recognized risk factor of Alzheimer’s disease (AD), is mainly due to the role played by insulin resistance on neuronal degeneration. Mild Cognitive Impairment (MCI) also significantly increases the risk of developing AD by approxim...

Impact of platelet-rich plasma (PRP) intra-articular injection on functioning and kinematic analysis in knee osteoarthritis patients: A prospective observational study

Purpose Osteoarthritis (OA) is a degenerative joint disease primarily affecting elderly, with the knee being the most involved joint. Platelet-Rich Plasma (PRP) therapy has shown promise in OA management. Our study aimed to descriptively characterize changes over time in performa...

Muscular Response in Sleep-Disordered Breathing Patients: New Methods of Assessment and Measurement

Background: Obstructive sleep apnea (OSA) is a heterogeneous disorder influenced by both anatomical collapsibility and non-anatomical factors, such as neuromuscular response. Identifying these traits through simplified clinical surrogates is crucial for personalized precision med...

The Therapeutic Potential of Berry-Derived and Berry-Based Interventions in Inflammatory Bowel Disease: A Comprehensive Systematic Review of Preclinical and Clinical Evidence

Introduction: Berry-derived and berry-based interventions have gained increasing attention for their potential health benefits. Berries are rich in diverse bioactive compounds, including polyphenols and anthocyanins, which are associated with a broad range of biological activitie...

Monoclonal antibody therapies for migraine: principles and applications

Migraine is a highly prevalent, disabling neurological disorder imposing a substantial global socioeconomic burden. The calcitonin gene–related peptide (CGRP) pathway plays a pivotal role in trigeminovascular activation, neurogenic inflammation, and pain transmission, making it a...

Therapeutic Drug Monitoring of Antifungal Agents: Toward Harmonization of Therapeutic Ranges

Background: Invasive fungal infections are associated with high morbidity and mortality, particularly among immunocompromised and critically ill patients. Antifungal therapy is complicated by substantial pharmacokinetic variability, drug–drug interactions, and narrow therapeutic...

Machine learning-guided screening of urine cultures for urinary tract infection diagnosis according to AMCLI guidelines

Urinary tract infections (UTIs) are among the most prevalent bacterial infections, and their diagnosis relies on the accurate interpretation of urine cultures. However, manual evaluation is time-consuming, operator-dependent, and susceptible to diagnostic variability. In this stu...

Competence, performance evaluation, and educational needs of middle nurse managers in the Italian healthcare system: A qualitative study

Background Existing literature highlights the essential role of middle nurse managers (MNMs) in ensuring communication, coordination, and quality within healthcare organisations, demonstrating the need for deeper insight into their competencies, educational needs, and evaluation...

New guidelines for the prevention of periprosthetic joint infection

Periprosthetic joint infection (PJI) remains one of the most serious complications of arthroplasty. Since the publication of major guidelines, several aspects of the prevention of PJI have been refined, although high-quality evidence remains limited in many areas. The aim of this...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Internalized weight stigma and associated clinical features in treatment-seeking adults with obesity: a multicenter Italian study

Abstract Background This study aimed to evaluate the prevalence and clinical correlates of internalized weight stigma in patients with obesity seeking treatment in various clinical centers across Italy. Methods A total of 438 patients with obesity were included. Patients complete...

Renewable, Low-Carbon and Recovered Energy Integration in Carbon-Capture Processes

Carbon capture could support deep decarbonisation only if the energy required for separation, regeneration, compression and refrigeration is supplied with low lifecycle emissions. This review approaches low-carbon and renewable energy integration into carbon-capture processes fro...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

Predicting levetiracetam neuropsychiatric adverse effects using graph‐theoretical electroencephalographic network metrics in drug‐naive focal epilepsy: A multicenter longitudinal study

Abstract Objective Levetiracetam (LEV) is an antiseizure medication approved for focal and generalized epilepsy. Despite its efficacy, neuropsychiatric adverse effects (NP‐AEs) may lead to treatment discontinuation. Quantitative electroencephalographic (qEEG) graph‐theoretical an...