Universidad de Buenos Aires

A comparative meta-analysis of amniotic membrane preservation methods: Balancing biological potency and clinical feasibility in ophthalmology

Objectives: The objective of the study is to systematically compare biological and structural properties of fresh, cryopreserved, lyophilized, and dehydrated human amniotic membrane (AM) and to quantify sufficiently comparable outcomes across preservation methods. Material and Me...

Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features

Background: Adipose tissue (AT) has emerged as a metabolically active component of the breast tumor microenvironment that contributes to breast cancer (BC) progression. Adipocytes release adipokines and lipids that influence tumor growth; however, the specific lipolytic proteins...

Integrating Remote Sensing and Indigenous Knowledge: A Community-Commanded Approach to Heritage Management in the Atacama Desert

Abstract This article presents the Zapar project, a community-commanded initiative developed in collaboration with the Atacameño Community of Toconao (northern Chile), which repositions remote sensing (RS) technologies through Indigenous governance and ethical frameworks. By embe...

Repositioning of cobalt chloride as a cardioprotective agent against ischemia/reperfusion injury in infant rats

Reperfusion is essential to prevent further deterioration of ischemic tissue, yet it can paradoxically exacerbate myocardial injury. Ischemia/reperfusion (I/R) injury is particularly relevant in pediatric patients with congenital or acquired heart disease, especially those underg...

BetaII-spectrin gaps and patches emerge from the patterned assembly of the actin/spectrin membrane skeleton in human motor neuron axons

The actin/spectrin membrane-associated periodic skeleton (MPS) is a cytoskeletal structure that supports axonal integrity and function. Lower spinal motor neurons (MNs) are characterized by exceptionally long axons and are particularly susceptible to degeneration in a wide range...

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage

The natural history of chronic hepatitis B virus (HBV) infection comprises distinct stages resulting from virus–host interactions. A late and pivotal event in this process is hepatitis B e antigen (HBeAg) seroconversion, marked by the abrogation of HBeAg expression, a significant...

The General Intellectual Humility Scale in Argentina: Adaptation and Validation

This study presents the adaptation and validation of the General Intellectual Humility Scale (GIHS) for Argentina, addressing the scarcity of Spanish-language instruments measuring this epistemic virtue. A sample of 201 Argentinian adults ( M = 58.9, SD = 16.6; 70.6% female) comp...

Bacterial Communities Associated with Deschampsia antarctica in Chronically Diesel-Contaminated Soils: Candidate Taxa for Microbe-Assisted Phytoremediation

More than six decades of human activity in Antarctica resulted in chronic diesel contamination of soils surrounding research stations. Phytoremediation assisted by the native vascular plant Deschampsia antarctica is one of the few remediation strategies compatible with the Antarc...

Soil physical quality and organic carbon in agricultural systems of the Dry Chaco: influence of land use intensity and predictive models

Context The expansion of the agricultural frontier in northwestern Argentina occurred at the expense of deforestation of native forests, particularly in the Dry Chaco. This land-use change alters soil physical properties and soil organic carbon (SOC), compromising sustainability....

Subchronic Cannabidiol (CBD) Treatment During the Silent Period Fails to Prevent Increased Seizure Susceptibility Following Lithium-Pilocarpine-Induced Status Epilepticus

Introduction. In recent years, cannabidiol (CBD) has been used as an adjunct therapy to anti-seizure medications for the control of seizures in patients with drug-resistant epilepsy. In addition to its anticonvulsant effect, CBD also has well-defined anti-inflammatory properties....

Neuropathological Effects of Early Maternal Separation are Prevented by CORT113176, A Glucocorticoid Receptor Modulator

Early-life stress, such as maternal separation (MS), disrupts the pup´s hypothalamic–pituitary–adrenal (HPA) axis and causes neuropathological changes in several nervous system regions, including the spinal cord. This damage is driven by glucocorticoid receptor (GR) overactivatio...

Expected redshift drift for tilted observers

Abstract Redshift drift is usually discussed for observers comoving with the cosmological background, but realistic observations are made by observers with nonzero peculiar motion. In this work, we calculate the expected redshift drift for tilted observers within the covariant 1...

eDNA Metabarcoding Reveals Spatial Patterns of Marine Communities Along the Beagle Channel (Tierra del Fuego, Argentina)

The Beagle Channel, located south of Tierra del Fuego (~54° S), is South America’s southernmost intracoastal ecosystem. Here, we applied environmental DNA metabarcoding using a partial sequence of the 12sRNA mitochondrial gene to evaluate the seasonal and spatial dynamics of mari...

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors

Fibroblast growth factor receptor 3 ( FGFR3 ) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors. However, the underlying gene regulatory network (GRN) remains poorly char...

Adolescents’ Emotional Intelligence and Self-Perception in the Context of Social Media Use

This study examined the relationships between perceived emotional intelligence (EI), self-esteem, self-concept, and social media use in a sample of 173 Argentinian adolescents (mean age 16.6). Using the TMMS to assess three EI dimensions (attention, clarity, and mood repair) alon...