Universidad Autónoma de Madrid

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Effects of Bacillus coagulans and the biomass of Spirulina platensis on quality characteristics and probiotic viability of gluten free cupcakes

In this study, gluten-free corn flour cupcakes were formulated with different levels of Spirulina platensis (0, 1, 2, and 3%) and the probiotic bacterium Bacillus coagulans (0 and 1%), and their physicochemical, microbial, textural, and sensory properties and probiotic survival w...

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

Abstract Background Myeloid cells orchestrate vascular inflammation through transcriptional programs that regulate their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, understanding of the transcriptional r...

Microscopic screening theory for excitons in two-dimensional materials: a bridge between effective models and ab initio descriptions

We present a computational approach for exciton calculations in two-dimensional (2D) materials within the Bethe–Salpeter equation (BSE) framework, employing an atomistic description with point-like orbitals. Unlike widespread efficient calculations that rely on classical or effec...

Proteo‐Metabolomic Profiling of PMM2 ‐ CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo ‐Inositol, and the Hexosamine Pathway

ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways,...

Spiro-helicenoidCarbofluoresceins: CPL-Active Emittersfor Bioimaging

Abstract Chiral fluorescent probes based on small organic molecules present a promising platform for advanced bioimaging applications. In this work, we have developed a helically chiral spiro-shaped carbofluorescein with red emission (λem ≤ 613 nm). Configurationally stable enant...

Clean Extraction Methodologies for High-Added-Value Olive Oil Production and Whole Valorization of the Olive Fruit

Olive oil production is an economically and culturally important agro-industrial activity, particularly in Mediterranean regions, but conventional extraction processes generate significant quantities of by-products and may lead to the loss of valuable bioactive compounds. In this...

The rights of nature: A paradigm shift in light of the case of the Mar Menor

This article addresses the complex relationship between ecological justice and time based on the first case of recognition of rights of nature in Europe: the attribution of legal personality to the Mar Menor in Spain. The case of the Mar Menor is presented as a legal reaction to...

Causes of death and mortality patterns in clozapine-treated patients: 17-year retrospective cohort study

Background Clozapine reduces overall mortality and suicide risk in schizophrenia, but the specific causes and clinical contexts of death among clozapine-treated patients remain less well characterised. Aims We aimed to characterise causes of death in clozapine-treated patients wi...

Weighted gradient estimates and refined existence results for a Hardy-type elliptic equation

Abstract We review Dirichlet-type problems of the form $$ -\Delta u=\lambda \frac{u}{|x|^2}+ g(\cdot ,\nabla u) \quad \text {in }\Omega ,\qquad u=0\ \text {on }\partial \Omega , $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mo>-</mml:mo> <mml:mi>Δ</...

Working conditions and mental health among doctors and nurses in the European Union, Iceland, and Norway: a cross-sectional survey

Background Europe faces persistent challenges in retaining and recruiting healthcare workers. Poor working conditions and deteriorating wellbeing may contribute to attrition and turnover intentions, yet large-scale studies examining associations between working conditions and men...

Enthalpies of formation, proton affinities, and gas-phase basicities of protonated azoles and quaternary azolium salts

Abstract The enthalpies of formation of five families of azoles, parent, protonated parent, neutral N -methyl azoles, protonated N -methyl azoles, and N,N -dimethyl quaternary salts from pyrazole to benzotriazole, in all, 82 compounds, have been studied theoretically and compared...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...

A clinical and experimental investigation of liraglutide effects on the brain-kidney axis

Glucagon-like peptide-1 receptor agonists elicit diuresis and natriuresis in humans and rodents. However, little is known about their interactions with the bodies hormonal systems that control fluid homeostasis. We performed a single center, open-label, before-and-after study and...

Tunable Oxygen Connectivity in Carbaporphyrinoid Polymers on Metal Surfaces

ABSTRACT Controlling oxygen‐mediated connectivity at metal surfaces offers a powerful route to engineer covalent and metal–organic architectures with atomic precision. Here, we demonstrate tunable oxygen‐based connectivity in carbaporphyrinoid polymers on Au(111) under ultrahigh...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Towards Personalized Medicine in Chronic Kidney Disease: A Roadmap for the future of Early Detection, Diagnosis, and Management: A Consensus Roadmap from the EUTox, PerMedik and KidneyHealth networks

Chronic kidney disease (CKD) affects more than 800 million individuals worldwide and represents one of the fastest‑growing causes of morbidity and mortality. Despite major therapeutic advances, CKD is frequently detected only after substantial and irreversible loss of kidney func...

Characterization and treatment of polymicrobial biofilms in prosthetic joint infections

Abstract Prosthetic joint infections are complex and associated with high economic and social costs. Polymicrobial cases remain poorly understood, particularly regarding bacterial interactions and antibiotic response within mixed-species biofilms. We introduce two approaches for...

Epigenetic changes reveal that vitamin B12 intake is associated with lower insulin resistance in older adults

Abstract Background Dietary choices influence both risk and development of type 2 diabetes (T2D), but the precise mechanisms remain incompletely described. Dietary intake and lifestyle behaviors can alter epigenetic states with subsequent modulations on gene expression which then...

Integrating Kidney Imaging for Risk Prediction, Therapeutic Monitoring, and Prognostication Across the Kidney Disease Spectrum: A Review of Emerging Evidence

Abstract Kidney imaging advances are transforming the field of nephrology by allowing non-invasive examination of renal structure, function, and pathology. Traditional measures such as albuminuria and estimated glomerular filtration rate (eGFR) are only partially effective in ide...