Universidad Autónoma de Madrid

Prospective economic evaluation of a predictive artificial intelligence model for sepsis: Effects on hospital costs and return on investment

Early sepsis detection is essential for improving outcomes and reducing costs, but traditional rule-based systems have limited accuracy and real-world evidence for machine-learning alternatives remains scarce. In this context, BIAlert-Sepsis predicts sepsis risk within 24 hours u...

INPP5E interactome reveals novel connections to growth factor signaling

Abstract Primary cilia are sensory cell membrane protrusions whose malfunction causes diseases known as ciliopathies. Joubert syndrome (JBTS) is a rare recessive ciliopathy causing brain malformations and kidney cysts, among other manifestations. A key player in JBTS is INPP5E, a...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Burden of diagnosed and undetected hyperkalemia in Spain: Clinical characteristics, management, healthcare resource utilization, and costs

BACKGROUND: Management of hyperkalemia (HK) is challenging and suboptimal. This study analyzed the prevalence of HK and undetected HK, as well as management, clinical outcomes, healthcare resource utilization (HCRU), and costs. METHODS: Observational study comprising cross-sectio...

Trop-2 overexpression as a prognostic marker in early triple-negative breast cancer: results from the GEICAM_CIBOMA trial

Trophoblast cell-surface antigen 2 (Trop-2) is a key therapeutic target in metastatic triple-negative breast cancer (TNBC), yet its prognostic significance in early-stage disease remains poorly defined. We evaluated Trop-2 expression and its clinical impact within a sub-cohort of...

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy

CD19-CAR-T cells are a major therapy for relapsed/refractory B-cell malignancies, yet ~50% of patients relapse after infusion. Clinical data suggest that tisa-cel treatment is associated with higher rates of CD19 mutation than axi-cel, though direct comparisons have been lacking....

Developmental trajectories of vigilance in childhood and adolescence: Disentangling underlying mechanisms through behavioral modeling.

Sustained attention is crucial for daily functioning, yet research on vigilance development has yielded inconsistent findings. These discrepancies arise partly from the use of tasks with different vigilance demands and from limitations in the indices of sensitivity and response c...

China’s dual circulation strategy and its impact on European industry: the case of the electric vehicle

Abstract In recent years, the Chinese economy has been hit by several shocks that have heightened the country’s economic security imperative. However, Beijing’s search for greater ‘self-reliance’ is not entirely new. China has often shifted its attention between domestic and glob...

Anisotropy of Satellite Galaxies. I. Contrasting Correlations with Central Galaxy, Host Halo, and Large-scale Filament Structures

Abstract Using the SIMBA, EAGLE, and IllustrisTNG-100 galaxy formation simulations, we examine the anisotropy of the satellite distribution and its dependencies on central galaxies, host halos, and cosmic filaments. We find that in all simulations, the satellite anisotropy is rob...

Faunal Deposits in Pre-Beaker Funerary Contexts at Humanejos (Parla, Madrid, Spain)

This study presents the first zooarchaeological analysis of the faunal remains associated with the pre-Beaker funerary contexts of Humanejos (Parla, Madrid, Spain). A total of 3974 animal remains recovered from 31 burial pits were analysed. Species representation was assessed usi...

Merryfield's inequality for multiparameter martingales

Abstract We extend an inequality of Merryfield, valid in the continuous setting, to discrete multiparameter martingales. As a consequence, we obtain the comparison of the maximal function with the square function: for regular multiparameter filtrations and . This estimate is new...

Three‐Dimensional Optical and Computational Reconstruction of Colloidal Electrokinetic Flows via Multiplane Imaging and Multiscale Modeling

ABSTRACT Sorting, filtering, and controlling colloidal particles is crucial in many fields, ranging from chemistry to biology and physics. Dielectrophoresis (DEP) enables selective manipulation of colloids by non‐uniform AC electric fields, yet the associated three‐dimensional na...

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

ABSTRACT Living cell therapies lack robust, reversible mechanisms for externally controlling therapeutic activity after administration, limiting their safety and clinical adaptability. Here we engineer a drug‐gated cellular immunotherapy platform in which T cells function as prog...

From Sustainability to Regeneration: A Scoping Review of Nursing Practices in the Construction of Green and Healthy Hospitals

Background/Objectives: The healthcare sector accounts for an estimated 1–5% of the global environmental footprint, and hospitals concentrate a large share of that impact. As the largest professional group, nurses are pivotal to the transition toward green and regenerative hospita...

Language and usage patterns on Twitch: a gender-sensitive study of viewers and streamers

Abstract Purpose This study examines gendered communication and interactional dynamics on Twitch as a platform-mediated environment, analyzing usage practices and linguistic patterns among Spanish university student viewers and exploring the experiences of female video game strea...

Vulnerable microbial communities in Atacama-Altiplano wetlands: modern analogs of ancient ecosystems with implications for sustainability and conservation

Abstract The Altiplano-Puna plateau lies at ∼4,000 m above sea level in the volcanic Andes cordillera. Together with the adjacent Atacama Desert, it forms one of the most hyperarid regions on the planet. Wetlands are rare, influenced by hydrothermalism and, due to high evaporatio...

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System

Background/Objectives: Pharmacogenetics (PGx) may improve drug safety and effectiveness, but its integration into routine care remains heterogeneous across the Spanish National Health System (NHS). This article presents BioFRAM PGx, a multicentre implementation framework that def...

Adaptive thermogenesis and fermentation as survival strategies of vegetative cells of Bacillus subtilis under simulated Martian stressors

<title>Abstract</title> Microbial responses to Mars‑analog environments are key to understanding the limits of life and improving life‑detection strategies. Here, we investigated the survival and physiological adaptation of <italic>Bacillus subtilis</italic> exposed for five sols...

Cord blood DNA methylation differences associated with gestational diabetes and partial consistency with maternal methylation patterns

Gestational diabetes mellitus (GDM) increases offspring cardiometabolic risk, potentially through intrauterine epigenetic programming. We aimed to characterize GDM-associated DNA methylation differences in cord blood, evaluate their consistency with previously identified maternal...

Does Women’s Political Empowerment Matter for Income Inequality?

This study investigates the relationship between women’s political empowerment and income inequality in a global sample of 142 countries from 1990 to 2019. Employing a combination of machine learning techniques with an instrumental variable panel data approach, the analysis revea...