Universidad Autónoma de Madrid

Language and usage patterns on Twitch: a gender-sensitive study of viewers and streamers

Abstract Purpose This study examines gendered communication and interactional dynamics on Twitch as a platform-mediated environment, analyzing usage practices and linguistic patterns among Spanish university student viewers and exploring the experiences of female video game strea...

Vulnerable microbial communities in Atacama-Altiplano wetlands: modern analogs of ancient ecosystems with implications for sustainability and conservation

Abstract The Altiplano-Puna plateau lies at ∼4,000 m above sea level in the volcanic Andes cordillera. Together with the adjacent Atacama Desert, it forms one of the most hyperarid regions on the planet. Wetlands are rare, influenced by hydrothermalism and, due to high evaporatio...

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System

Background/Objectives: Pharmacogenetics (PGx) may improve drug safety and effectiveness, but its integration into routine care remains heterogeneous across the Spanish National Health System (NHS). This article presents BioFRAM PGx, a multicentre implementation framework that def...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Cord blood DNA methylation differences associated with gestational diabetes and partial consistency with maternal methylation patterns

Gestational diabetes mellitus (GDM) increases offspring cardiometabolic risk, potentially through intrauterine epigenetic programming. We aimed to characterize GDM-associated DNA methylation differences in cord blood, evaluate their consistency with previously identified maternal...

Does Women’s Political Empowerment Matter for Income Inequality?

This study investigates the relationship between women’s political empowerment and income inequality in a global sample of 142 countries from 1990 to 2019. Employing a combination of machine learning techniques with an instrumental variable panel data approach, the analysis revea...

Adaptive thermogenesis and fermentation as survival strategies of vegetative cells of Bacillus subtilis under simulated Martian stressors

<title>Abstract</title> Microbial responses to Mars‑analog environments are key to understanding the limits of life and improving life‑detection strategies. Here, we investigated the survival and physiological adaptation of <italic>Bacillus subtilis</italic> exposed for five sols...

Effects of Bacillus coagulans and the biomass of Spirulina platensis on quality characteristics and probiotic viability of gluten free cupcakes

In this study, gluten-free corn flour cupcakes were formulated with different levels of Spirulina platensis (0, 1, 2, and 3%) and the probiotic bacterium Bacillus coagulans (0 and 1%), and their physicochemical, microbial, textural, and sensory properties and probiotic survival w...

Microscopic screening theory for excitons in two-dimensional materials: a bridge between effective models and ab initio descriptions

We present a computational approach for exciton calculations in two-dimensional (2D) materials within the Bethe–Salpeter equation (BSE) framework, employing an atomistic description with point-like orbitals. Unlike widespread efficient calculations that rely on classical or effec...

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

Abstract Background Myeloid cells orchestrate vascular inflammation through transcriptional programs that regulate their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, understanding of the transcriptional r...

Spiro-helicenoidCarbofluoresceins: CPL-Active Emittersfor Bioimaging

Abstract Chiral fluorescent probes based on small organic molecules present a promising platform for advanced bioimaging applications. In this work, we have developed a helically chiral spiro-shaped carbofluorescein with red emission (λem ≤ 613 nm). Configurationally stable enant...

Proteo‐Metabolomic Profiling of PMM2 ‐ CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo ‐Inositol, and the Hexosamine Pathway

ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways,...

The rights of nature: A paradigm shift in light of the case of the Mar Menor

This article addresses the complex relationship between ecological justice and time based on the first case of recognition of rights of nature in Europe: the attribution of legal personality to the Mar Menor in Spain. The case of the Mar Menor is presented as a legal reaction to...

Clean Extraction Methodologies for High-Added-Value Olive Oil Production and Whole Valorization of the Olive Fruit

Olive oil production is an economically and culturally important agro-industrial activity, particularly in Mediterranean regions, but conventional extraction processes generate significant quantities of by-products and may lead to the loss of valuable bioactive compounds. In this...

Causes of death and mortality patterns in clozapine-treated patients: 17-year retrospective cohort study

Background Clozapine reduces overall mortality and suicide risk in schizophrenia, but the specific causes and clinical contexts of death among clozapine-treated patients remain less well characterised. Aims We aimed to characterise causes of death in clozapine-treated patients wi...

Weighted gradient estimates and refined existence results for a Hardy-type elliptic equation

Abstract We review Dirichlet-type problems of the form $$ -\Delta u=\lambda \frac{u}{|x|^2}+ g(\cdot ,\nabla u) \quad \text {in }\Omega ,\qquad u=0\ \text {on }\partial \Omega , $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mo>-</mml:mo> <mml:mi>Δ</...

Working conditions and mental health among doctors and nurses in the European Union, Iceland, and Norway: a cross-sectional survey

Background Europe faces persistent challenges in retaining and recruiting healthcare workers. Poor working conditions and deteriorating wellbeing may contribute to attrition and turnover intentions, yet large-scale studies examining associations between working conditions and men...

Enthalpies of formation, proton affinities, and gas-phase basicities of protonated azoles and quaternary azolium salts

Abstract The enthalpies of formation of five families of azoles, parent, protonated parent, neutral N -methyl azoles, protonated N -methyl azoles, and N,N -dimethyl quaternary salts from pyrazole to benzotriazole, in all, 82 compounds, have been studied theoretically and compared...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...

A clinical and experimental investigation of liraglutide effects on the brain-kidney axis

Glucagon-like peptide-1 receptor agonists elicit diuresis and natriuresis in humans and rodents. However, little is known about their interactions with the bodies hormonal systems that control fluid homeostasis. We performed a single center, open-label, before-and-after study and...