Union Hospital

Biological age acceleration and mortality risk among U.S. adults with cardio-kidney-metabolic syndrome, stages 0–3

This study aims to evaluate the associations of Klemera-Doubal Method Biological Age Acceleration (KDM-BAA) and Phenotypic Age Acceleration (PAA) with all-cause and cause-specific mortality in U.S. adults with Cardio-Kidney-Metabolic (CKM) syndrome stages 0–3 and to establish ris...

Secondary prevention of cancer therapy-induced thrombocytopenia with hetrombopag in breast cancer: a multicenter, randomized, exploratory phase II trial

Abstract Background: Cancer therapy-induced thrombocytopenia (CTIT) is a common complication of anti-tumor therapy, leading to treatment delays or interruptions, increased bleeding risk and compromised outcomes. In the present study, we aimed to evaluate the efficacy and safety o...

Targeting NOX1/4 promotes macrophage phagocytosis and improves radiotherapy via YAP1/TEAD4-CD47 in non-small cell lung cancer

Abstract Radiotherapy is a mainstay treatment option for non-small cell lung cancer (NSCLC). However, radiation remodels the tumor immune microenvironment by adaptively upregulating the immunoregulatory checkpoint CD47, leading to phagocytic evasion and radioresistance. Although...

Association between LDL-C/HDL-C ratio and atrial fibrillation risk in chronic heart failure patients

Lipid levels are negatively correlated with atrial fibrillation (AF) in the general population. We aimed to investigate the correlation between low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and AF in chronic heart failure (CHF). We...

Sirtuin 1 Inhibition Attenuates Viral Myocarditis by Suppressing the Nuclear Translocation of Pyruvate Kinase M2 to Rebalance Th17/Th9 Differentiation

Sirtuin 1 (SIRT1) regulates CD4 + T cell differentiation, particularly Th17 and Th9 subsets, in various autoimmune and inflammatory diseases, but its role in viral myocarditis (VMC) remains poorly understood. In this study, using a coxsackievirus B3 (CVB3)-induced VMC mouse model...

Immuno-PET imaging of mesothelin in ovarian cancer with 68Ga-XH04: a first-in-human study

Mesothelin is highly expressed in ovarian cancer and represents a promising target for precision imaging and therapy. This study aimed to develop and evaluate ⁶⁸Ga-XH04, a novel mesothelin-targeted immuno-PET tracer for non-invasive imaging of mesothelin expression in preclinical...

Postoperative surveillance strategy in patients undergoing neoadjuvant chemoradiotherapy followed by curative resection for locally advanced rectal cancer

Abstract Background There are no consistent recommendations for postoperative surveillance intervals for rectal cancer in the major guidelines. Knowledge about recurrence hazards can help develop appropriate surveillance schedules. This study aimed to investigate transitions in r...

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

ABSTRACT Patients with sepsis exhibit circadian disruption and persistent immunosuppression. However, the molecular mechanisms linking them remain unclear. Integration of multi‐cohort transcriptomic and single‐cell datasets shows that circadian gene dysregulation in patients with...

Risk prediction model and intervention strategies for intraoperative hypothermia in robotic-assisted urological surgery

To develop a risk prediction model for intraoperative hypothermia in patients undergoing robotic-assisted urological surgery and formulate hierarchical warming strategies. This single-centre retrospective study calculated the sample size using G*Power 3.1. A total of 487 patients...

P1.137. Baseline Skeletal Muscle Depletion Stratifies Treatment Feasibility and Survival in Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Neoadjuvant Immunochemotherapy

Abstract Topic Esophageal Cancer: Other Background Physiological reserve plays a pivotal role in determining the capacity of patients to tolerate intensive multimodal therapy. In locally advanced esophageal squamous cell carcinoma (ESCC), neoadjuvant immunochemotherapy (nICT) has...

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

Nasal Brushing Transcriptomics Reveals Candidate Biomarkers of Glucocorticoid Treatment Response in Allergic Rhinitis

The authors declare no conflicts of interest. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the arti...

Research engagement profiles among Chinese undergraduate and postgraduate students

Research engagement is increasingly recognized as an important component of student development in higher education, particularly in medical and health sciences disciplines, but it is often measured through isolated activities or publication status alone. This study examined rese...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Nuciferine-Loaded Lipid Nanoparticle Microneedles Alleviate Intervertebral Disc Degeneration by Restoring Nucleus Pulposus Cell Homeostasis

Background/Objectives: Intervertebral disc degeneration (IDD) is a major cause of chronic low back pain and disability. Nuciferine, a natural alkaloid with mitochondrial protective activity, shows therapeutic potential for IDD. However, the avascular nature of intervertebral disc...

Hepatocyte OTUD1 promotes hepatic stellate cell activation and liver fibrosis by stabilizing HSP90β

Crosstalk between parenchymal and nonparenchymal cells of the liver mediates the activation of hepatic stellate cells (HSCs). Activated HSCs transform into myofibroblasts and produce the extracellular matrix (ECM), and massive ECM accumulation can affect liver function and eventu...

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Postoperative pain impairs patients' quality of life. Mechanisms underlying postoperative pain remain incompletely understood. We investigated postoperative pain in a mouse model of skin plus deep tissue incision (INC). We found Cxcl5 was among the top upregulated genes in incisi...

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy is largely ineffective in most solid tumors, partially because of inadequate intratumoral trafficking. Bridging therapy, administered between leukapheresis and CAR‐T cell infusion, offers a distinct opportunity to control th...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...