Union Hospital

Associations of Triglyceride Glucose Index-related Obesity Indices, Genetic Susceptibility, and the Risk of Venous Thromboembolism: Insights from a Prospective Cohort Study

Abstract The triglyceride glucose (TyG) index and related obesity metrics are commonly recognized as important indicators of insulin resistance. However, the associations of several novel TyG-related obesity indices developed with venous thromboembolism (VTE) risk and their inter...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

High prevalence and immunophenotypic diversity of clonal T‑large granular lymphocytes in JAK2‑mutated myeloproliferative neoplasms

Patients with JAK2‑mutated MPN may develop clonal T‑cell expansions, but the prevalence, immunophenotypic spectrum, and association with other lymphoid clones remain poorly defined. Clonal T‑large granular lymphocyte (T‑LGL) expansions have been observed in myeloproliferative neo...

The effect of compression stockings on patients with lower extremity venous ulcers: A meta-analysis

Objective This study aims to systematically evaluate the efficacy and safety of compression stockings compared with other active compression modalities and surgical interventions in the management of venous leg ulcers, and to explore the impacts of intervention duration, reported...

Targeting the NOTCH1 signaling pathway in chronic lymphocytic leukemia enhances the efficacy of CD19 CAR-T cells

Abstract Background The therapeutic efficacy of chimeric antigen receptor T (CAR-T) cells targeting CD19 in chronic lymphocytic leukemia (CLL) treatment can be limited by target cell antigen loss. This study aims to elucidate how the intrinsic NOTCH1 signaling activity in CLL cel...

An ROS‐Responsive CeO 2 –Selenium Nanozyme Mitigates Renal Injury via Coordinated Ferroptosis Inhibition and Inflammation Resolution

ABSTRACT Acute kidney injury (AKI) and chronic kidney disease (CKD), despite distinct etiologies, share a common pathological axis characterized by reactive oxygen species (ROS) burst, ferroptosis activation, and sustained inflammation. Targeting this ROS–ferroptosis–inflammation...

Payment reform, remuneration incentives, and changes in service utilization and institutional revenue composition: an interrupted time-series analysis from Sanming, China

Hospital-centred service delivery and underused primary care can reduce health-system efficiency. We examined changes in service utilization, provider distribution, and institutional revenue composition during Sanming’s health reform. We analysed 144 monthly observations from Jan...

Urine metabolomics reveals key pathways supporting neuronal regeneration and consciousness recovery in disorders of consciousness

Disorders of consciousness (DoC) are debilitating conditions resulting from severe brain injury, requiring not only structural preservation but also active neuronal regeneration for recovery. These regenerative processes are metabolically demanding and can be tracked through syst...

Intrapartum ultrasound in the second-stage labor: a meta-analysis and evidence appraisal of clinical outcomes and safety

Abstract Background Accurate assessment of fetal head position and descent during the second stage of labor is essential for safe decision-making, but digital examination is subjective and operator-dependent. Intrapartum ultrasound has been proposed as an objective adjunct, yet i...

Neurotoxicity of PM2.5-Bound Multi-Pollutant Mixtures in Parkinson’s Disease: Exploring the INPP5D/SHIP1-PI3K-AKT Axis via an Integrative Multi-Omics Study

Accumulating epidemiological evidence links ambient PM2.5 exposure to elevated Parkinson’s disease (PD) risk, yet the neurotoxicity triggered by PM2.5 multi-pollutant mixtures under real co-exposure scenarios remains insufficiently elucidated. This study integrated two-sample Men...

Aptamer-functionalized EGCG nanocarrier for neutrophil-targeted AKBA delivery promotes anxiety-related fracture healing

Anxiety is clinically associated with impaired fracture healing, but the underlying immunological mechanism remains unclear, and no targeted therapy is available. In a mouse model of chronic restraint stress (CRS)-induced anxiety with femoral fracture, we observed expansion of TG...

Synergistic prognostic value of tumor-infiltrating lymphocytes and microvessel density in breast cancer

Breast cancer is a heterogeneous disease forming an intricate ecosystem, and its prognosis is affected by multiple factors, with the complexity of the tumor microenvironment (TME) being a pivotal determinant. Tumor-infiltrating lymphocytes (TILs) and microvessels, as key componen...

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other...

Central and bridge nodes in depression, anxiety, and resilience networks across adolescent latent profiles: a latent profile and network analysis

Resilience is closely associated with adolescent mental health, but patterns of its co-occurrence with depression and anxiety symptoms remain unclear. This study combined latent profile analysis (LPA) and network analysis to characterize symptom-resilience profiles and examine ne...

Nomograms based on clinical characteristics and baseline dual-layer spectral detector computed tomography imaging parameters: potential clinical utility in predicting the efficacy of first-line lymphoma treatment

Abstract Background Spectral computed tomography (CT) is considered a useful tool for predicting tumor treatment response and survival. However, its role in lymphoma treatment remains unclear. The purpose of this study was to develop spectral CT-based nomogram for predicting resp...

Balloon guide catheter outcomes by occlusion site in the randomized PROTECT-MT trial

Background Balloon guide catheters (BGCs) are used during endovascular thrombectomy, but whether their effect varies by occlusion site is uncertain. We evaluated effect modification by baseline occlusion site in the PROTECT-MT trial. Methods This exploratory secondary analysis of...

Development and validation of a nomogram for predicting 28-day mortality in critically ill liver cirrhotic patients with coagulopathy

Although scoring systems exist to predict outcomes in patients with cirrhosis, specific systems for critically ill cirrhotic patients with coagulopathy are lacking. The aim of the study was to establish a reliable predictive model for 28-day mortality in cirrhotic patients with c...

Triglyceride glucose index, metabolic comorbidity, and cardiovascular disease: a national cohort study

The triglyceride-glucose (TyG) index, a widely accepted surrogate biomarker of insulin resistance, strongly predicts cardiovascular disease (CVD) risk. However, the mediating role of metabolic comorbidities in explaining the relationship between the TyG index and cardiovascular d...

Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy

Anoikis presents an alternative scheme for suppressing tumor metastasis. While limited by off-target effects, rapid degradation, and reactive oxygen species (ROS) accumulation, anoikis resistance remains a persistent challenge for current tumor therapy. The use of external and en...