Union Hospital

Triglyceride glucose index, metabolic comorbidity, and cardiovascular disease: a national cohort study

The triglyceride-glucose (TyG) index, a widely accepted surrogate biomarker of insulin resistance, strongly predicts cardiovascular disease (CVD) risk. However, the mediating role of metabolic comorbidities in explaining the relationship between the TyG index and cardiovascular d...

Visualized self-propelled nanorobots overcome tumor barriers for boosted photothermal-nanocatalytic synergistic therapy against triple-negative breast cancer

Conventional nanozyme-based therapeutics for triple-negative breast cancer (TNBC) are severely hindered by insufficient tumor penetration and lysosomal degradation-induced enzyme inactivation, crippling therapeutic efficacy. Herein, we rationally construct visualized dual-propell...

Risk factors for postoperative hypoxemia in Stanford type A aortic dissection: a cohort study from the Hubei Aortic Dissection Registration Database

Abstract Background For patients with Stanford type A aortic dissection (STAAD), moderate-to-severe hypoxemia is a common and serious complication after surgery. However, its independent risk factors are not yet well understood, and there is a lack of effective early prediction t...

Repurposing diuretics for bipolar disorder: a Mendelian randomization study

Despite increasing therapeutic options to treat bipolar disorder (BD), many patients fail to reach treatment targets. The study sought to explore the potential of diuretics in preventing and treating BD through Mendelian randomization (MR). We utilized a two-sample MR design to a...

Sepsis: advances in diagnosis, management, and long-term outcomes—a narrative review

Abstract Sepsis is a complex and highly heterogeneous syndrome that resulted in approximately 11 million deaths worldwide in 2017 due to multiple organ failure, posing a serious threat to human life and health. With the advancement of medical technology, the definition of sepsis...

A succinylation-related machine learning signature reveals prognostic and immune heterogeneity in lung adenocarcinoma

Succinylation is an emerging post-translational modification involved in tumor metabolism and progression. However, the role of succinylation-related genes (SRGs) in lung adenocarcinoma (LUAD) remains poorly understood. This study aimed to systematically investigate the prognosti...

APOC1 deficiency disrupts M1/M2 macrophage balance via the ferroptosis and suppresses trophoblast invasion in recurrent pregnancy loss

The maternal–fetal interface requires tightly regulated immune homeostasis for successful pregnancy. Dysregulation of macrophage polarization and trophoblast invasion is implicated in recurrent pregnancy loss (RPL). However, the molecular mechanisms by which macrophage dysfunctio...

Recent advances in anticoagulant-related nephropathy: risk factors, peribiopsy and therapeutic anticoagulation

Abstract The concept of anticoagulant-related nephropathy (ARN), first proposed in 2009, manifests as acute kidney injury or the rapid deterioration of chronic kidney disease secondary to anticoagulant therapy. Large numbers of tubular RBCs and/or tubular RBC casts and ATN, witho...

Development and validation of a knowledge, attitude, and practice questionnaire for management of metabolic complications after solid organ transplantation among medical staff

Metabolic diseases are common complications after solid organ transplantation (SOT) and significantly affect recipients’ quality of life and long-term survival. To our knowledge, no validated questionnaire specifically evaluates medical staff’s knowledge, attitude and practice (K...

Lactylation of OVOL2 impairs its tumor-suppressive activity to promote hepatocellular carcinoma growth

Lactylation, a metabolism-associated post-translational modification derived from lactate accumulation, has emerged as an important regulator linking metabolic reprogramming to cancer progression. Increasing evidence suggests that lactylation participates in tumor development thr...

Peripheral immune influences on the brain: adaptive immune T and B cells regulate cognitive dysfunction

Abstract Cognitive dysfunction is recognized as one of the most concerning complications in aging as well as in disease states such as neurodegenerative disorders and stroke. Although previous studies mainly focused on local brain pathology, growing evidence highlights neuroimmun...

Quantitative image feature integrated digital pathology model based on deep learning and machine learning for binary histological severity stratification of ulcerative colitis

The STRIDE II consensus recognizes histopathological healing in ulcerative colitis as a key therapeutic target. This study aimed to develop and internally evaluate a quantitative image-based model for the binary classification of mild versus moderate-to-severe UC based on histopa...

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study

Abstract Aims The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations....

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Multimodal large language model–assisted workflow for image-dependent very short answer question generation and response grading in neurosurgical residency assessment: development and validation study

Very short answer questions (VSAQs) reduce cueing but require substantial specialist effort to develop and grade, particularly when they involve neuroimaging. We evaluated an expert-supervised workflow using multimodal large language models (LLMs) to generate image-dependent neur...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

A Novel Sparse Cellular Labeling System with Tunable Gradients and Long‐Term Stability

ABSTRACT The dense packing of cells within tissues poses challenges for studying cellular properties. Sparse labeling, genetically targeting a small subset of densely distributed cells, provides a powerful approach to investigate cellular morphology, connectivity, dynamics, and f...

The unbalanced needs and perceived supply of supportive care in family caregivers of patients with multiple myeloma: a cross-sectional study

Abstract Background Understanding the needs of family caregivers of patients with cancer and providing appropriate support are essential to ease the burden of illness, facilitate family management, and reduce the risk of adverse health outcomes. Currently, the unmet supportive ca...

Citation landscape and research themes of robotic-assisted total hip arthroplasty: a bibliometric analysis of the 100 most-cited English-language publications in the Web of Science Core Collection

Robotic-assisted total hip arthroplasty (ra-THA) has received increasing academic attention. This bibliometric study aimed to identify the 100 most-cited English-language articles related to ra-THA indexed in the Web of Science Core Collection (WOSCC) and to characterize their ci...

Development of a Three‐Layered Fascial Architecture in the Rabbit Carotid Sheath: Histological Findings Consistent With Mechanical Influences

Current understanding of the fascial structures within the human carotid sheath (CS) is largely based on static anatomical descriptions, with limited knowledge of their dynamic developmental process. This study aimed to characterise the developmental progression of the fascial ar...