Tsinghua University

A Chloroplast-Inspired Theranostic Nanoplatform for Self-Sustaining Oxygen-Elevating Photodynamic Therapy and Glutathione-Triggered Carbon-Centered Radical Synergistic Therapy

Abstract Achieving precise drug delivery to the tumor site can minimize systemic side effects caused by off-target effects. As a therapy that depends on oxygen content, photodynamic therapy (PDT) is significantly constrained by the hypoxic nature of the tumor microenvironment (TM...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...

Effects of human mobility on tuberculosis incidence in mainland China, 2010–2023: an ecological analysis and metapopulation modeling study

Human mobility plays an important role in the transmission of infectious diseases, yet its contribution to tuberculosis (TB) dynamics in China remains insufficiently quantified. We compiled a province-year panel for mainland China (2010–2023) to describe spatiotemporal trends usi...

The ER–Golgi intermediate compartment: a central hub integrating membrane trafficking and stress responses

Abstract The endoplasmic reticulum–Golgi intermediate compartment (ERGIC) is a dynamic membrane system at the ER–Golgi interface, traditionally viewed as a transient station for COPII- and COPI-dependent trafficking. Emerging evidence redefines the ERGIC as a stress-responsive re...

Serial transthoracic echocardiography for hemodynamic monitoring and early warning of hypotension during elective cesarean delivery: a prospective observational study

Abstract BACKGROUND : Spinal anesthesia during cesarean delivery frequently causes maternal hypotension. Early detection of hemodynamic compromise before blood pressure decline could enable timely intervention. This study evaluates the use of serial transthoracic echocardiography...

Nickel-catalyzed enantioselective reductive vinyl-alkynylation of unactivated alkenes with bromoalkynes

Alkynyl groups are highly valuable functionalities, prompting chemists to continually seek efficient alkynylation reactions. Traditional asymmetric alkynylation strategies using terminal alkynes often rely on complex chiral phosphine ligands, stoichiometric amounts of silver reag...

Achieving simultaneous strength-ductility-corrosion optimization of solid-state additive friction stir deposited superlight Mg-Li alloy by a hybrid high flow rate Argon/CO₂ shielding atmosphere

High-performance Mg–Li alloys were fabricated via solid-state additive friction stir deposition under a mixed Ar/liquid CO₂ atmosphere, which addresses severe oxidation and unfavorable thermal cycling issues during additive manufacturing. Benefiting from optimized microstructures...

Survival of the Flattest: Teams with Low (But Not High) Status Differentiation Turn Failure into Success by Adding High-Status Members

Most prior research on teams’ responses to failure treats teams as closed systems. However, after failures, teams may seek to improve performance by bringing in new members. Adopting a teams-as-open-systems perspective, we test which teams are more willing to add high-status memb...

Strategic design of methane observation networks to improve emission estimates: A case study in Africa

Abstract. Ground-based and satellite atmospheric observations are essential for reducing uncertainties in methane (CH4) emissions by atmospheric inversion, particularly in data-sparse regions such as Africa. However, adding new observation sites does not yield linear improvements...

Automated CT segmentation of diffuse pseudomyxoma peritonei lesions using a hybrid deep learning model

Abstract Purpose To develop and externally validate DATUnet—a hybrid deep learning framework integrating DenseBlock encoding, atrous spatial pyramid pooling (ASPP), and a lightweight Transformer bottleneck—for automated segmentation of diffuse pseudomyxoma peritonei (PMP) lesions...

Optimal canopy light-use strategy shapes global greenness dynamics

“Greenness” is a key indicator of the functional state of vegetation. However, the physiological processes behind seasonal patterns in greenness are diverse and incompletely understood, hindering the predictability of climate-driven shifts in global foliage phenology. Optimality...

Deciphering EcoFitness of marine ecosystems through eDNA cross-trophic interactions

Abstract Effective assessment of marine ecosystems increasingly requires approaches that go beyond static biodiversity indices to capture cross-trophic organization and dynamic stability based on network topology. In this study, we applied a multi-marker (12S, 18S, COI) eDNA meta...

Valorization of Wastewater Phosphorus into Battery-Grade FePO4 via In-Situ Anodic Precipitation in an Electro-Driven Membrane System

Abstract The exponential growth of the new energy vehicle market has precipitated an urgent demand for sustainable lithium iron phosphate (LiFePO4) precursors. While recovering iron phosphate (FePO4) from phosphorus-rich wastewater presents a viable supply chain solution, convent...

Engineering Hidden Ferroelectric‐Like Distortion for Ultralow Thermal Conductivity in Polar van der Waals Tetradymite

ABSTRACT Ferroelectric‐like polar structures enable diverse functionalities through coupling with charge and phonon transport. Although effective in modulating thermal conductivity, the rational design of novel polar materials with intrinsically low thermal conductivity via ferro...

Viscoelasticity-guided covalent assembly of atomically precise nanoclusters via nitrene-mediated two-photon lithography

The translation of atomically precise metal nanoclusters into functional macroscopic devices is restricted by the difficulty of scaling manufacturing while preserving fragile quantum structures. Although two-photon lithography offers a route for micro-fabrication, the absence of...

Desire, Ruin, and Ecological Resistance: Reading Sanduk Through Eco-socialism and Eco-feminism

This study examines Siddhartha Chanakya’s SandukFootnote1 (2025), an independent Indian film that transforms the imagery of war into a radical ecological allegory of life at the limits of the Anthropocene. Set in a post-nuclear wasteland stripped of history and national identity,...

Facilitating megacity electricity decarbonization via grid-interactive demand-side resource management

City power systems face intensified mismatches between generation and dynamic demand under rising zero-carbon energy penetration levels. Although demand-side resource management offers mismatch mitigation potential by regulating load patterns, its city-level capability remains un...

Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes

Excessive dietary fructose consumption contributes to the rapidly increasing prevalence of obesity, metabolic syndrome, and chronic kidney disease worldwide, and accumulating preclinical evidence has confirmed that excess fructose exposure provokes severe mitochondrial dysfunctio...

Overwhelmed and Exhausted: Exploring the Antecedents and Outcomes of Information Fatigue Through the Stressor-Strain-Outcome Model

Despite digital platforms increasingly optimizing for engagement, less work has addressed how users experience and adapt to the resulting fatigue. This qualitative study employs the Stressor-Strain-Outcome (SSO) model to investigate information fatigue in digital environments. Fo...

A MultitaskLarge Reasoning Model for Molecular Science

Abstract Artificial intelligence in molecular science must move beyond pattern recognition toward chemically valid and interpretable reasoning. We present a task-adaptive large reasoning model that integrates chemical knowledge through a synergistic multispecialist architecture,...