Tianjin Medical University

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

ABSTRACT The blood–brain barrier (BBB), while indispensable for maintaining central nervous system (CNS) homeostasis, constitutes the principal impediment to effective therapeutic delivery for neurodegenerative disorders, particularly hindering spatially resolved modulation of ex...

Distal-first versus proximal-first laparoscopic nephroureterectomy for non-muscle-invasive upper tract urothelial carcinoma: a retrospective cohort study

Abstract Background and objective The optimal sequence of ureteral and vascular control during laparoscopic nephroureterectomy (LNU) for non-muscle-invasive (≤ pT1) upper tract urothelial carcinoma (UTUC) remains controversial. We compared distal-first (initial ureteral ligation)...

Systemic inflammatory factors combined with HR-VWI-based plaque vulnerability discriminate ischemic phenotypes and predict prognosis in patients with intracranial atherosclerosis

Abstract Background The relationship between systemic inflammation, plaque vulnerability, and stroke phenotypes in intracranial atherosclerotic stenosis (ICAS) is unclear. This study investigated inflammatory markers’ association with high-risk plaques and their value in differen...

Comparison of baseline characteristics between cognitively normal and mild cognitive impairment and association of white matter hyperintensity trajectories with diagnostic outcomes, cognition, and amyloid-β protein: A longitudinal study

Background White matter hyperintensity (WMH) is linked to mild cognitive impairment (MCI) and vascular dementia, but its longitudinal change as an independent risk factor remains unclear. Objective This study aims to compare baseline WMH across diagnostic outcomes, and evaluate h...

The Effect of Taurine on the Alkalinity Stress Resistance of Eriocheir sinensis

High alkalinity, a major stress in saline–alkaline water, often leads to oxidative damage and apoptosis. Taurine has been shown to enhance the tolerance of aquatic animals to environmental stress, but whether it can reduce toxicity of alkalinity on Chinese mitten crab (Eriocheir...

Exercise-specific mechanical stimuli are associated with regional lumbar bone adaptation: a combined in vivo and in silico multi-scale study

Abstract Background Exercise is widely recommended to maintain lumbar bone mineral density (BMD), the tissue-level mechanical environment generated within the lumbar spine during different exercises remains difficult to assess in vivo. This study integrated individualized musculo...

Endoscopic submucosal resection with band ligation versus endoscopic submucosal excavation for small (≤ 10 mm) gastric muscularis propria-derived lesions: a real-world retrospective cohort study with long-term follow-up

The optimal management of small (≤ 10 mm) gastric subepithelial lesions (SELs) arising from the muscularis propria (MP) remains controversial. Endoscopic submucosal resection with band ligation (ESMR-L) is a simplified resection technique that may improve procedural efficiency co...

Associations of remnant cholesterol and apolipoprotein B with kidney function decline and progression to kidney failure in hospitalized patients with type 2 diabetic kidney disease: a retrospective cohort study

Diabetic kidney disease (DKD) is one of the leading causes of kidney failure (KF). Emerging lipid markers such as remnant cholesterol (RC) and apolipoprotein B (ApoB) have been associated with kidney disease progression. However, no study has comprehensively evaluated the associa...

Woven dECM yarn scaffolds enable volumetric muscle loss regeneration via immunomodulation

Volumetric muscle loss (VML) represents a significant unmet clinical need in current medical practice. Decellularized extracellular matrix (dECM) offers a promising clinical approach. However, its inherent architecture impedes adaptive topological guidance for rapid cellular infi...

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

To date, the treatment of acute myeloid leukaemia (AML) remains a major challenge in hematologic malignancies, particularly among elderly patients who are unfit for intensive chemotherapy. Venetoclax, a BCL-2 inhibitor, in combination with azacitidine, has significantly improved...

An adenovirus-based multiantigen vaccine protects against tuberculosis by coordinating adaptive immunity and curbing immunosuppressive mechanisms

ABSTRACT Given that tuberculosis (TB) remains the leading cause of death from a single infectious agent, and that vaccination is the most effective control strategy, we systematically compared several vaccine construction strategies using a chimpanzee adenovirus vector platform....

Gut microbiota‑driven indole‑3‑propionic acid protects against sepsis‑associated encephalopathy via inhibiting BNIP3L ubiquitination and restoring BNIP3L‑dependent mitophagy as a potential molecular mechanism

Sepsis-associated encephalopathy (SAE) is a severe refractory neurological complication occurring in up to 70% sepsis patients with no targeted therapies. Gut microbiota-derived indole-3-propionic acid (IPA), a tryptophan metabolite, exerts neuroprotective effects, but its therap...

Lactylation-related immune-metabolic dysregulation defines prognostic and therapeutic stratification in lung adenocarcinoma

Background Lactylation links lactate metabolism with inflammatory signaling and immune regulation in tumors. However, its cellular distribution and translational value in lung adenocarcinoma (LUAD) remain unclear. Methods Single-cell RNA-sequencing datasets GSE189357 and GSE17114...

Value of Multi-Parameter Combined Application of CZT-SPECT and CCTA in Risk Stratification of Short-Term Myocardial Ischemic Events in Patients with Chronic Coronary Syndromes

Background: This study aimed to investigate the predictive value of the multi-parameter combined application of cadmium–zinc–telluride single-photon emission computed tomography (CZT-SPECT) and coronary computed tomography angiography (CCTA) for short-term myocardial ischemic eve...

Plant Cell-on-Chip (PCOC): Exploring the Electrical Modulation Capability of Plant Cells

The intrinsic properties of plants offer numerous opportunities for scientific and technological advancement. Considerable efforts have been directed toward developing plant-on-chip platforms to investigate cellular responses to external stimuli, including chemical, mechanical, a...

LDL-C–stratified residual lipoprotein(a) and inflammatory risk after acute myocardial infarction among patients with prior statin use

Abstract Background Patients can experience acute myocardial infarction (AMI) despite documented prior statin exposure, indicating persistent residual cardiovascular risk. The prognostic relevance of lipoprotein(a) [Lp(a)] and residual inflammation in this setting remains unclear...

Association between PD-1/PD-L1 Expression and Clinicopathological Parameters as well as Prognosis in Neuroendocrine Neoplasms of the Digestive System: A Systematic Review and Meta-Analysis

Abstract Neuroendocrine neoplasms (NENs) are a highly heterogeneous group of tumors originating from the neuroendocrine system, predominantly occurring in the gastrointestinal tract and lungs. This meta-analysis aimed to clarify the association of programmed death 1 (PD-1)/progra...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer

Abstract Loss of primary cilia is common in cancer, but its relevance to molecular subtypes of muscle-invasive bladder cancer (MIBC) is unclear. Here, we combined transcriptomic and co-expression analyses with experiments in bladder cancer cell lines, human tumor specimens, and x...