Tianjin Medical University

Commensal Lachnospiraceae bacterium mitigates colitis-induced mucin fucosylation deficits through ILC3/IL-22 axis

Flagellins from commensal bacteria are potent modulators of intestinal immunity, yet their strain-specific functions, particularly in promoting homeostasis in ulcerative colitis (UC), remain poorly defined. We investigate whether flagellin from the commensal Lachnospiraceae bacte...

The association between adolescent interoceptive awareness and future exercise possible self: a mediation model

Objective Based on the perspective of embodied cognition, this study examined the association between interoceptive awareness and future exercise possible self among adolescents, and investigated the mediating roles of self-concept clarity and athletic engagement in this associat...

The VCX/VCY gene family member VCX3A encodes an RNA-binding protein that modulates the proliferation and motility of spermatogonia GC-1 cells via pre-mRNA splicing

VCX3A , a member of the VCX / VCY gene family, is predominantly expressed in spermatogonia of the male testis. Emerging evidence implicates that mutations or duplication of VCX3A may contribute to nonobstructive azoospermia. Although VCX3A has been characterized as a nuclear RNA-...

Coniferaldehyde Reverses PGK1–3-Phosphoglycerate–L-Serine Metabolic Reprogramming in Hindlimb Ischemia

Background/Objectives: Ischemic skeletal muscle undergoes metabolic remodeling that may influence vascular repair. We investigated whether coniferaldehyde (CA) regulates a phosphoglycerate kinase 1 (PGK1)–3-phosphoglycerate (3PG)–L-serine axis in mouse hindlimb ischemia (HLI). Me...

Non-monotonic cardiovascular adaptation and stroke output-stroke output coupling reorganization in high-altitude adolescents: a cross-sectional study along altitude gradients

Abstract Cardiovascular adaptation to chronic high-altitude exposure during adolescence remains incompletely understood because developmental autonomic regulation may differ from adult acclimatization. We examined whether cardiovascular responses vary non-monotonically across alt...

Single-Cell and Spatial Transcriptomics Reveal CHCHD3 as a Therapeutic Target to Activate cGAS-STING and Overcome Immunosuppression in Lung Adenocarcinoma

Abstract A substantial proportion of treatment-naive lung adenocarcinoma (LUAD) patients exhibit intrinsic resistance to neoadjuvant chemoimmunotherapy, highlighting the need for mechanism-driven therapeutic strategies. Here, we performed integrated single-cell RNA sequencing (sc...

Association between respiratory phenotypes and successful ventilator liberation in early-onset and late-onset ARDS: a multicenter cohort study

Early-onset and late-onset acute respiratory distress syndrome (ARDS) differ in clinical course and outcomes, but their longitudinal respiratory trajectories remain unclear. We aimed to characterize respiratory trajectories in early- and late-onset ARDS and identify trajectory-ba...

Quantification of Urinary Free and Total Oxidative Stress Biomarkers and Their Differential Associations with Polycyclic Aromatic Hydrocarbon Exposure: A Bushfire Smoke Study

Abstract Urinary excretion profiles of free and metabolically conjugated oxidative stress biomarkers (OSBs) remain poorly characterized, potentially underestimating total excretion and biasing exposure–effect interpretation. In this study, the profiles of free, glucuronidated, an...

Deep-sea Microbial Dataset of the Antarctic Ocean (dsMDAO): A high-resolution deep-sea microbial dataset of the Antarctic Ocean reveals potential for taxonomic and functional diversity

Antarctic deep-sea ecosystems harboured unique and metabolically versatile micro-organisms that sustained key biogeochemical processes under extreme polar conditions. However, the genomic diversity and ecological functions of these sedimentary or deep-sea microbial communities re...

Differential gut microbial signatures induced by exercise intensity and mode in aging SAMP6 mice

The aging population faces increased risks of metabolic and cognitive decline, with emerging evidence linking gut microbiota to exercise-mediated health benefits. Senescence-accelerated mouse prone 6 (SAMP6) exhibits early aging phenotypes, while senescence-resistant 1 (SAMR1) se...

Pathological mechanisms of long non-coding RNA FOXD2-AS1 promoting osteosarcoma mediated by the COI-1/OCN/Runx-2 signaling pathway

Introduction Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Despite three decades of research efforts, no significant improvement in patient survival rates has been achieved, highlighting the urgent need for in-depth investigation i...

Dynamic kinetics of graft-derived cell-free DNA and personalized tacrolimus target ranges for acute rejection monitoring in pediatric liver transplantation

Introduction Acute rejection remains the most common complication during the early post-transplantation period for pediatric patients. Given the limitations of current diagnostic strategies, there is an urgent need to develop accurate and noninvasive biomarkers for allograft moni...

Targeting USP14 disrupts lipid metabolism and survival pathways in diffuse large B-cell lymphoma (DLBCL)

Abstract Proteasome inhibitors have transformed cancer therapy in certain settings. However, their overall effectiveness is often limited as residual proteasome function is retained through the overexpression of ubiquitin-specific protease 14 (USP14), a proteasome-associated deub...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

White Blood Cell to HDL ‐C Ratio and Sarcopenia: A Dual‐Cohort Analysis Including Exploratory Insights on Hepatitis B History

ABSTRACT Background Sarcopenia, driven by inflammation and lipid dysregulation, lacks inexpensive screening tools. The white blood cell to HDL‐C ratio (WHR) integrates these pathways, but its utility for sarcopenia screening remains unvalidated. Objective This study evaluated the...

From structural design to model compression: Research progress on lightweight algorithms for motor imagery brain–computer interfaces

Abstract Motor imagery brain–computer interfaces (MI‐BCIs) enable direct brain‐to‐device communication by decoding movement intentions from EEG signals. Although deep learning models have significantly improved decoding accuracy, their high computational complexity and large para...

Increased gamma oscillations and inter-regional brain asymmetry associated with sepsis-associated delirium: a prospective cohort study

Sepsis-associated delirium (SAD) is thought to involve disrupted functional brain network connectivity. The aim of this study was to characterize the electroencephalographic (EEG) features of SAD and to develop a predictive model based on these features. Of 98 eligible patients w...

Comparison of quantitative CT parameters acquired via the CT spine bone quantification system between L1 cortical and cancellous bone for predicting severity in male patients with chronic obstructive pulmonary disease: a retrospective study

Until present, data on the association between cortical bone changes in osteoporosis and severity of the condition of Chronic obstructive pulmonary disease (COPD) patients are lacking. This study aims to explore and compare the value of quantitative parameters of cortical and can...

Porous Polymeric Materials for Cell Delivery and Regenerative Therapy: Design Principles, AI‐Assisted Optimization, and Clinical Translation

ABSTRACT Cell therapy is increasingly recognized as a cornerstone of 21st‐century medical innovation, but its success heavily relies on the effective delivery of therapeutic cells to the target site while maintaining their viability and functionality. Traditional intravenous inje...

Asb2-KIF11 Axis Protects Against Heart Failure by Restoring Lysosomal Distribution and Mitochondrial Homeostasis

BACKGROUND: Heart failure remains a leading cause of mortality globally, driven by persistent mitochondrial dysfunction and maladaptive cardiac hypertrophy. Although impaired autophagic flux contributes to cardiac deterioration, the precise molecular mechanisms are still unclear....