Temple University

Increased encoding of aversive stimuli by lateral habenula neurons during Δ9-tetrahydrocannabinol withdrawal

Abstract The lateral habenula (LHb) integrates cortical and basal forebrain (BF) input and is implicated in negative affective states, but its involvement in negative affect associated with cannabis withdrawal is unknown. Here, effects of withdrawal from the psychoactive cannabis...

Victimization and Mental Health Among Youth With and Without Disabilities: Results From a State-Wide Sample of Youth in the Juvenile Justice System

Youth with disabilities experience disproportionately high levels of victimization, yet little is known about whether victimization and resilience factors shape mental health outcomes differently for justice‑involved youth with and without disabilities. Drawing on ten years of ca...

Emotional Reliance on Artificial Intelligence: A Scoping Review of AI Companionship and Mental Health Implications

Background: Artificial intelligence (AI)-driven conversational systems are increasingly capable of simulating empathy, adapting to individual users, and fostering emotional bonds that blur the boundary between tool and companion. This scoping review maps the extent and nature of...

Patient-focused intervention versus enhanced care-as-usual in facilitating gynecologic cancer patients’ clinical communication about sexual health: protocol for a randomized controlled trial

Sexual problems are common, distressing, and persistent for patients with gynecologic cancer (GC). Yet patients with GC often hesitate to raise sexual concerns with their clinicians due to discomfort and inadequate preparation for the discussion. The objective was to evaluate the...

Integrated O 2 and H 2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

ABSTRACT Impaired wound healing in diabetes is closely associated with cellular ferroptosis. Microneedle‐assisted gas therapy exerts molecular regulation of ferroptosis, representing a promising approach for accelerating diabetic wound healing. To date, O 2 and H 2 gas therapies...

Neural tracking of surprisal in Spanish-English bilingual children during naturalistic heritage language listening

Our understanding of the neurobiology of language development is imprecise, particularly for bilingual children in their heritage language, since much research focuses on monolingual children or societal majority languages. In this study, we use a novel computational approach wit...

Kinematics-based assessment of reaching and grasping movements in LRN ablated animals identifies a role for the LRN in endpoint stabilization and reach timing

The lateral reticular nucleus (LRN) is positioned to relay motor-related information to cerebellar circuits, but its direct contribution to skilled reaching and grasping remains unclear. Here, we examined skilled forelimb behavior in intact adult female Long-Evans rats after bila...

SGLT2 inhibitors activate pantothenate kinase in the human heart

Abstract Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i remains unclear. We show here that SGLT2i...

Bridging the Policy-to-Practice Gap: Professionals’ Knowledge, Perspectives, and Experiences Following Passage of Legislation Concerning Disabled Parents in Idaho

Parents with disabilities and their children experience disparities within the child welfare system. In response, states are increasingly enacting legislation to protect the rights of these families. As the first state to pass comprehensive legislation concerning parents with dis...

Temple-Biology-YangLab/2026-Nature-Communication-SingleNup: v1.0.0 – Nature Communications Archival Release

Nature Communications archival release This release contains the data and analysis code supporting the study: "Live-cell 3D mapping reveals the organized architecture of FG-nucleoporins within the nuclear pore complex." The repository includes the data and scripts used to support...

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

Abstract The loss of smooth muscle cell (SMC) contractile phenotype contributes to various diseases including atherosclerosis. However, its metabolic basis is not entirely elucidated. Since the transforming growth factor beta (TGFβ) signaling is among principal regulators of SMC...

K9HeartCircDB: a circRNA atlas of tachypacing-induced canine dilated cardiomyopathy

ABSTRACT Cardiovascular disease (CVD) remains a leading cause of death worldwide. Dilated cardiomyopathy (DCM), a major cause of heart failure (HF), exhibits ventricular dilation, impaired systolic/diastolic function, arrythmias, and adverse cardiac remodeling. While genetic caus...

Neural Organization of Episodic Memory and Navigation in Children and Adults

Abstract Episodic memory and spatial navigation are often viewed as interlinked, in part due to their shared reliance on medial-temporal lobe (MTL) structures. At the same time, there are important differences, for example, natural spatial navigation requires moving one's body th...

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Chronic Obstructive Pulmonary disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are chronic pulmonary disorders with distinct pathologies but shared risk factors. Metabolomics may provide insights into mechanisms. To identify metabolites associated with COPD and IPF, and to...

Automated optimization of force field parameters against ensemble-averaged measurements with Bayesian inference of conformational populations

Accurate force fields are essential for reliable molecular simulations. These models are refined against quantum mechanical calculations and experimental measurements, which are subject to random and systematic errors. Bayesian Inference of Conformational Populations (BICePs) is...

Distinguishing Between Enforceable and On-The-Books State-Level Abortion Policies Over Time: Findings From a Policy Surveillance Study

OBJECTIVES: To describe trends in state-level abortion policies before the Dobbs v Jackson Supreme Court decision, distinguishing laws that have been enacted through legislation/regulation and are thus "on-the-books" from laws that are enforceable, ie, "on-the-books" laws not blo...

Loss of Quasiconvexity in the Periodic Homogenization of Viscous Hamilton–Jacobi Equations

Abstract. We show that in the periodic homogenization of uniformly elliptic Hamilton–Jacobi equations with quasiconvex Hamiltonians in arbitrary dimensions, the effective Hamiltonian is not necessarily quasiconvex. This observation is in sharp contrast with the first-order case,...

Cross-cultural adaptation of cancer health literacy instruments in Arabic: the CHLT-30-Arabic and CHLT-6-Arabic

Background Health literacy plays a crucial role in physical and mental health outcomes. Patients with chronic diseases, cancer patients in particular, shoulder a disproportionate burden due to limited health literacy. Limited cancer health literacy (LCHL) is a risk factor for dis...

Patient-centered approaches in psoriasis management: lessons from the past and future directions

INTRODUCTION: Psoriasis is a chronic immune-mediated disease with physical and psychosocial burden that is not fully captured by measures of skin lesion characteristics. Advances in therapies, including multiple biologic treatments, have improved disease control, but gaps remain...

Failure Modes of Total Wrist Arthroplasty: Cross-Sectional Analysis of FDA MAUDE Adverse Event Reports (2015-2025)

Background: Total wrist arthroplasty (TWA) is a motion-preserving alternative to wrist fusion for end-stage wrist arthritis, but concerns regarding long-term durability continue to limit broader use. Reported 10-year survivorship ranges from 70% to 80%, although real-world failur...