Temple University

Poetry attention–adjusted endowment and tourism demand

This study examines how historical poetry heritage affects tourism demand when activated by contemporary cultural attention. We propose Poetry Attention-Adjusted Endowment (PAE), conceptualizing poetry heritage as a latent cultural asset whose economic relevance depends on time-v...

On fixed points of pseudo-Anosov maps

We give a formula to estimate the number of fixed points of a pseudo-Anosov homeomorphism of a surface. When the homeomorphism satisfies a mild property called strong irreducibility , the log of the number of fixed points is coarsely equal to the Teichmüller translation length. W...

Mitochondrial carbonic anhydrase–VB inhibition rescues brain endothelial stress and memory in Alzheimer’s disease models

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no effective cure, characterized by the cerebral parenchymal and vascular accumulation of aggregated amyloid-β (Aβ) and hyperphosphorylated tau. Cerebrovascular and mitochondria dysfunction are early causal...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Antarctic sea ice response to meltwater due to Antarctic ice sheet mass loss in a multi-model ensemble

Abstract. We present the first multi-model study of the Antarctic sea ice response to enhanced meltwater due to dynamic mass loss from the Antarctic ice sheet. This meltwater flux (and its future increase under global warming) is not included in the most recent state-of-the-art c...

Generalized Snell’s Law and Maxwell Equations

Abstract. This paper examines the Maxwell system of electrodynamics within the framework of distributions. A primary objective is to establish general boundary conditions for fields at interfaces when the charge and current densities are measures localized on the interface. From...

Feeling included by AI: belonging and authenticity in human–AI interaction

Purpose This study aims to examine how users’ experiences of artificial intelligence (AI) inclusion, reflected in feelings of belonging and authenticity during human–AI interaction, are associated with user satisfaction and interactional justice. Design/methodology/approach The s...

Pseudomonas aeruginosa Pyocyanin Increases Airway Mucin Biosynthesis by SIRT1-Mediated FOXA2 Inactivation

The potent redox-cycling Pseudomonas aeruginosa secondary metabolite pyocyanin induces acute and persistent oxidative stress in diseased airways. Pyocyanin promotes goblet cell hyperplasia and metaplasia and exacerbates the mucus burden. Forkhead Box A2 (FOXA2) is a key pioneer f...

Cyclin/CDK inhibition in cancer therapy: from small molecules and macrocycles to advanced drug delivery systems

Cyclin-CDK complexes have attracted growing interest as therapeutic targets due to their crucial role in cell cycle regulation and their application in cancer treatment. Moreover, although CDKs were considered downstream effectors of the DNA damage response (DDR), several evidenc...

Effects of End-ischemic Hypothermic Oxygenated Perfusion on 1-y Graft Function in Kidney Transplantation: A Real-world, Single-center Analysis From the United States.

Background: Hypothermic oxygenated perfusion (HOPE) supplies oxygen to kidney allografts for resuscitation before transplantation and may improve graft recovery. This study represents the first U.S.-based comparative analysis evaluating the impact of HOPE on kidney transplant (KT...

The WoKaS-Iso database: workflow for a global compilation of oxygen-18 and deuterium records in karst springs and cave drip water for enhanced understanding of karst systems

For analysing karst hydrogeological systems, observations of karst springs and cave drips are considered indispensable. In addition to hydrometric observations, knowing the oxygen and hydrogen stable isotope ratios has improved the understanding of vadose zone and aquifer dynamic...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

The Association of Essential Micronutrients in Serum with Immune-Mediated Inflammatory Diseases: A Cross-Sectional Study from NHANES

Background: Immune-mediated inflammatory diseases (IMIDs) occur when the immune system attacks the body’s own tissues, affecting approximately 8% of the global population. Objective: This study investigated the serum levels of a few redox-relevant essential micronutrients, aiming...

Convergent validity of measures of daily functioning in older adults

INTRODUCTION: Although information on daily functioning is needed for accurate diagnoses of neurocognitive disorders, little has been published on the psychometric properties of measures of daily functioning. Convergent validity is one such psychometric property that examines the...

The shifting landscape of assessment in STEM education in the age of generative AI

Abstract This article focuses on the impact of generative AI (GenAI) on assessment in STEM education. Guided by the assessment triangle as a conceptual framework, we take an ecosystems perspective to review the extant STEM education literature and identify how GenAI affects what...

Extracorporeal cardiopulmonary resuscitation for cardiogenic shock in a Jehovah’s witness

Abstract Veno-arterial (V-A) and veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) are frequently employed in the management of cardiopulmonary failure in critically ill patients. Utilization, however, is controversial in the Jehovah’s Witness (JW) population as tempor...

Flat-Band-Assisted Nitrogen Reduction on M-N4 Single-Atom Catalysts in a Two-Dimensional Tetraaza[8]circulene Framework

Abstract The porphyrin-like M-N4 coordination environment embedded in two-dimensional (2D) lattices represents a compelling design principle for single-atom electrocatalysts (SACs) targeting the electrochemical nitrogen reduction reaction (eNRR). Density functional theory (DFT) c...

User Experience and Satisfaction With a Web‐Based Application to Improve Intelligibility in Parkinson's Disease

ABSTRACT Background/Objectives Motor speech impairments, such as hypokinetic dysarthria, are highly prevalent among individuals with Parkinson's disease (PD). These voice and speech deficits may significantly impact speech intelligibility, leading many individuals with PD to with...

Alcohol and E-Cigarettes Activate P2X7R in Lung Epithelial Cells, Stimulating Release of Plasminogen Activator in Extracellular Vesicles, Injuring Blood-Brain Barrier

Chronic alcohol and nicotine exposure can increase susceptibility to lung injury and promote the release of extracellular ATP (eATP). Elevated eATP activates the purinergic P2X7 receptor (P2X7R), a membrane ion channel that amplifies inflammatory signaling and promotes extracellu...

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

BACKGROUND: Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin-6 (IL-6) inhibitor, is the only FDA-approved treatment for adult patients with iMCD. Limited...