Effects of End-ischemic Hypothermic Oxygenated Perfusion on 1-y Graft Function in Kidney Transplantation: A Real-world, Single-center Analysis From the United States.
Abstract
Background: Hypothermic oxygenated perfusion (HOPE) supplies oxygen to kidney allografts for resuscitation before transplantation and may improve graft recovery. This study represents the first U.S.-based comparative analysis evaluating the impact of HOPE on kidney transplant (KT) outcomes. Methods: -values of <0.05 were considered significant. Results: = 0.011). Conclusions: HOPE preservation is associated with improved long-term graft function compared with HMP while maintaining outcomes compared with SCS despite longer preservation times, with notable benefits in DCD-KT.
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Authors: Justin A. Steggerda, Tiffany Lim, Irene K. Kim, Tsuyoshi Todo, Edmund Huang, Todd V. Brennan, Georgios Voidonikolas, Alice Peng, Reiad Najjar, Jun Shoji, Sindhu Chandran, Benjamin Ferrel, José Reyes-Pérez, Manaf Alsudaney, Peter S. Heeger, Steven A. Wisel
Institutions: Temple University, Cedars-Sinai Medical Center, Providence Sacred Heart Medical Center