Tel Aviv University

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Economic hardship and mental health following a national trauma and amid ongoing conflict: a longitudinal cohort study

Abstract Purpose Exposure to war and terrorism increases the risk of mental health problems and often leads to economic hardship, which can further heighten psychological distress. This longitudinal study examined the extent of economic hardship experienced during the Israel–Hama...

Pediatric Mycosis Fungoides and Hydroa Vacciniforme Lymphoproliferative Disorder

Patients most often present with hypopigmented patches, though folliculotropic disease is also common. Prognosis is usually excellent. Most patients are diagnosed with early-stage disease, and less than 5% of cases progress to late-stage disease. Pediatric MF can be difficult to...

Variation in cataract surgical outcomes by facility type: evidence from 168 population-based surveys in 61 countries

Background/aims To compare visual outcomes after cataract surgery between outreach camps and fixed facilities, and among government, non-governmental organisation (NGO) and private providers within fixed facilities. Methods Pooled cross-sectional analysis of 41 881 cataract-opera...

Truthful visualizations for mass spectrometry imaging enable high-spatial-resolution interactive m/z mapping and exploration

Mass spectrometry imaging (MSI) produces high-dimensional molecular data, but practical interpretation remains limited by visualizations that incompletely preserve global structure. We present MSI-VISUAL, an open-source framework for interactive MSI analysis that integrates truth...

Colon-specific epigenetic clocks from minimal features reveal disease-driven aging

Abstract Epigenetic clocks estimate chronological and biological age from DNA methylation patterns, but conventional models typically train on hundreds of thousands of CpG sites and large training cohorts. We previously demonstrated that tissue-unique methylation sites change in...

Bridging worldsheet CFTs and wormholes

A bstract I provide multiple examples of conformal field theories (CFTs) on the world-sheet that describe string propagation in target space wormholes connecting two disjoint asymptotic manifolds. The worldsheet approach goes beyond the framework of supergravity by incorporating...

Prophylactic clip closure after right-colon endoscopic mucosal resection in a matched cohort of 470 patients exhibits sub-site heterogeneity

Background and study aims Clinically significant post-EMR bleeding (CSPEB) is the most common adverse event after endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (LNPCPs). Randomised trials of prophylactic through-the-scope clip (TTSC) closure have...

Resident autonomy in orthopedic trauma: independent femoral IMN by senior residents yields comparable outcomes to fellowship-trained surgeons

Abstract Introduction Intramedullary nailing (IMN) of femoral shaft fractures is a fundamental cornerstone procedure in orthopedic trauma and an important benchmark of resident surgical competency. While independent resident operating is essential for skill development, its safet...

Cirrhosis Risk in Sarcoidosis Without Documented Hepatic Involvement—A Large Nationwide Population‐Based Cohort Study

ABSTRACT Background & Aims Given the likely underestimation of hepatic sarcoidosis, the aims were to evaluate long‐term cirrhosis risk in patients with sarcoidosis without documented hepatic involvement at baseline and to assess the impact of multi‐organ disease and immunomodulat...

Parameters affecting the reliable measurement of fluconazole tolerance using disk diffusion assays with Candida albicans

ABSTRACT Disk diffusion assays (DDAs) are widely used to determine antimicrobial susceptibility, which is measured as the size of the zone of inhibition (ZOI) after 24 h of growth, and is inversely proportional to the minimal inhibitory concentration (MIC). DDAs can also be used...

Removing wolves did not reliably prevent domestic animal losses

Abstract Humans usually try to kill wild animals that they perceive as threats. However, many scientific findings have raised doubts that killing solves wildlife damage to property. With scant, low‐quality data, uncertainty persists. We reviewed recent studies of killing gray wol...

Photon‐Recycling Dielectric Laser Accelerator

ABSTRACT We propose a photon‐recycling dielectric laser accelerator (DLA) system based on silicon‐on‐insulator platform. Our DLA system employs transverse‐magnetic optical mode as the primary energy source, modulated and injected into the electron‐light interaction region for lon...

Encircling NATO: the evolution of Russia’s power-projection in the MENA region, 2011–2025

During the previous decade, Russia’s revisionist aspirations have defied the United States and its NATO allies’ purposes to preserve their dominant position in the current distribution of power. Contemporary literature argues that Russia’s policies in the Middle East and North Af...

FluorescentFarnesyl-Derived Probes Reveal DistinctIntracellular Localization Associated with Morphogenesis Suppressionin Candida albicans

Abstract Farnesol is a quorum-sensing sesquiterpene produced by Candida albicans that inhibits filamentation, a morphogenetic transition underlying fungal invasion and virulence. Notably, several farnesyl-derived sesquiterpenes bearing functional groups other than the original al...

Computer Science Beyond the Instrumental Paradox

Computer science confronts a strange moment: the technology unsettling its foundations is its own creation. Generative AI—built from the discipline's theory, algorithms, architectures, and data—now produces the very artifact around which the discipline organized itself: executabl...

Skills and technological innovations in the Middle Palaeolithic Levant: the Levallois approach at Givat Rabi East

The Levallois method is a hallmark of Middle Palaeolithic technology, reflecting complex cognitive and technical behaviours. This study analyses the Levallois assemblage from Givat Rabi East (GRE), an open-air site in the Levant, to investigate technological adaptability and cult...

Measuring Ocean Surface Waves

Abstract Propagating waves on the ocean surface can be represented as a stochastic process whose statistics are characterized by a spectrum. This paper reviews methods for measuring the wave spectrum and related quantities. Observations begin by sensing fluid dynamical properties...

Robotic, laparoscopic, and open nephrectomy and 30-day pulmonary morbidity: a procedure-stratified cohort study with intraoperative ventilation data

Previous studies of heterogeneous abdominal procedures have reported higher pulmonary-complication rates after robot-assisted surgery, but whether this applies to nephrectomy is uncertain. We evaluated surgical approach and 30-day postoperative pulmonary complications (PPCs) afte...

Donor Human Milk Implementation in a High-Mother’s-Own-Milk NICU: Impact on Feeding Progression and Clinical Outcomes in Extremely Low Birth Weight Infants

Background: Donor human milk (DHM) is recommended when the mother’s own milk (MOM) is unavailable for extremely low birth weight (ELBW) infants. However, the impact of DHM implementation on NICUs with already high human milk utilization remains incompletely characterized. Objecti...