Technical University of Munich

Photoinitiated Synthesis of a Covalent Pullulan and Beta Cyclodextrin Conjugate in Supercritical Carbon Dioxide

A three-stage route is proposed for the preparation of a covalent pullulan-beta-cyclodextrin conjugate through carboxymethylation of beta-cyclodextrin, EDC/NHS-mediated coupling with cysteamine, allylation of pullulan, and photoinitiated thiol-ene conjugation in a supercritical c...

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...

Analysis of Eulerian Methods for Droplet Collection Efficiency on Two-Dimensional Surfaces Under Aircraft Icing Conditions

The calculation of droplet collection efficiency is a critical procedure in numerical simulations of aircraft ice accretion and anti-/de-icing processes, in which the Eulerian framework is predominantly employed, especially on complex surfaces. Based on the droplet streamlines ob...

Transient receptor potential channel activation targets multiple stages of the schistosome parasite

Schistosomiasis, a neglected tropical disease caused by infection with parasitic blood flukes of the genus Schistosoma , affects more than 250 million people worldwide. Currently, patients rely on a single medicine, praziquantel (PZQ), discovered half a century ago. To combat dru...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Impact of on-site mobile CT imaging on prehospital patient management during the Munich Oktoberfest: a retrospective observational before–after study at a mass gathering

Abstract Background Mass gatherings such as the Munich Oktoberfest increase demand on Emergency Medical Services (EMS), particularly for trauma patients requiring imaging. Suspected mild traumatic brain injury (mTBI) often necessitates hospital referral and diagnostic imaging, pl...

InventOR: A Human-Reviewed, Prompt-Configured Large Language Model Decision Support System for Material-Level Inventory Control

Material planners must set a reorder point, a safety stock and an order quantity for thousands of plant-material pairs, usually under ERP parameters that were last revised long ago. We define and evaluate InventOR, a decision support system (DSS) for this recurring decision. For...

Becoming the bull : Structural insights and engineering strategies for ultralong CDR ‐ H3 paratopes from cattle

Cattle produce a subset of antibodies (Abs) with unique architecture. These immunoglobulins feature an ultralong CDR-H3 (uCDR-H3) composed of up to about 70 amino acids that protrudes from the scaffold and folds into a distinct stalk-and-knob structure. The knob is a disulfide-ri...

Optimizing nanoLC-TIMS-TOF and lipidomics sample preparation for low volume of plasma

Abstract Lipidomics provides critical insights into disease mechanisms, biomarker discovery, and precision medicine, but conventional LC-MS workflows often require sample volumes that limit their application in minimally invasive studies. Here, we evaluated a nanoflow liquid chro...

Moire Patterns-Based Low-Cost Flexible SERS Substrates for Multi-Analyte Detection of Biological and Chemical Molecules

Abstract Reliable detection across diverse analyte classes remains a significant challenge in surface-enhanced Raman spectroscopy (SERS), particularly when a single platform must address both biological and environmental targets. This work develops a geometrically engineered Moir...

Real-time process analysis and optimization of nitroguanidine synthesis in microflow using inline Raman spectroscopy

Non-contact inline Raman spectroscopy is used as a fast, flexible, and safe method for monitoring and optimizing continuous-flow processes involving highly hazardous and corrosive materials. The synthesis of nitroguanidine (NQ), an energetic material, was characterized and optimi...

Amid an Epistemic Iteration: How AI Methodologies May Transform the Nature of Science Education Research

Abstract Advancements in artificial intelligence (AI) may transform the nature of science (NOS). These transformations may extend to science education research, where AI methodologies increasingly enable scalable, reproducible, and fine‑grained analyses of student learning. To re...

Leptogenesis without on-shell right-handed neutrinos

A bstract We propose a novel mechanism for generating the baryon asymmetry of the Universe through leptogenesis in a scenario where the right-handed neutrinos are heavier than the maximal temperature of the Universe, and are never produced on-shell, neither by thermal nor by non-...

Evaluating the Impact of Explainable AI on Trust in AI-Assisted Code Review

The use of large language models (LLMs) for automated code review has brought significant change to a time-consuming part of software engineering. Prior work has shown that LLM-based code tools can improve code quality and enable more robust software development processes. As the...

Compiling Quantum Regular Language States

State preparation compilers for quantum computers typically sit at two extremes: general-purpose routines that treat the target as an opaque amplitude vector, and bespoke constructions for a handful of well-known state families. We ask whether a compiler can instead accept simple...

SEDCoT: Enhancing LLM-Based COBOL Code Translation via Symbolic Execution and Delta Debugging

COBOL remains critical across banking, insurance, and government infrastructure. However, maintenance is increasingly challenging due to outdated technologies, sparse documentation, and developer retirement, necessitating code translation into modern languages like C. Traditional...

RippleGUItester: Change-Aware Exploratory Testing

Software systems evolve continuously through frequent code changes, yet such changes often introduce unintended bugs despite extensive testing and code review. Existing testing approaches are largely constrained to predefined execution paths or rely on unguided exploration, leavi...

Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC‐3 Criteria: A Systematic Review and Meta‐Analysis

BACKGROUND: Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC-3 criteria to better classify proced...

Benchmarking Paper Recommendation Systems: What Does It Mean to Prove That They Work?

This seminar paper was prepared for “Bachelor/Master Seminar – Current/Hot Topics in Applied AI, Business Process Management, and Blockchain” at the Technical University of Munich during Summer Semester 2026. It reviews how paper recommendation, citation recommendation, and liter...

Benchmarking Paper Recommendation Systems: What Does It Mean to Prove That They Work?

This seminar paper was prepared for “Bachelor/Master Seminar – Current/Hot Topics in Applied AI, Business Process Management, and Blockchain” at the Technical University of Munich during Summer Semester 2026. It reviews how paper recommendation, citation recommendation, and liter...