Taipei Medical University

Global Prevalence of Adherence to Antihypertensives and Associated Moderating Factors Among Adults With Hypertension: A Meta‐Analysis

BACKGROUND: Hypertension is a significant public health issue affecting over a billion adults worldwide with adherence to antihypertensives being crucial for achieving sustained blood pressure control and reducing cardiovascular morbidity and mortality. To extend previous evidenc...

Hyperglycemia induces endothelial mitochondrial dysfunction and myeloperoxidase dysregulation in PCOS iPSCs

Polycystic ovary syndrome (PCOS) is associated with increased risks of cardiovascular disease (CVD), driven in part by endothelial dysfunction. Using patient-derived induced pluripotent stem cells (iPSCs), we established an endothelial model to examine cellular responses to metab...

Soluble N-terminal EphA2 fragment as a diagnostic biomarker and functional mediator of tumor progression in triple-negative breast cancer

Triple-negative breast cancer (TNBC) lacks reliable biomarkers for early detection and remains a highly aggressive disease. Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase frequently overexpressed in advanced cancers, undergoes MMP14-mediated cleavage that releases s...

Nanostructured PCL/MWCNT Composite Scaffolds Promote Cell Adhesion and Mineralized Matrix Formation for Bone Regeneration: SHED and MC3T3 Evaluation

Abstract The development of biomimetic scaffolds capable of simultaneously supporting stem cell viability and enhancing osteogenic differentiation remains a major challenge in bone tissue engineering. This study evaluated the effects of porous polycaprolactone (PCL)/multiwalled c...

High-power spray coagulation as knife-based hemostasis improves procedural efficiency in colorectal underwater endoscopic submucosal dissection

Underwater endoscopic submucosal dissection (UESD) has emerged as a promising alternative to conventional techniques, offering advantages for colorectal neoplasms. However, intraoperative bleeding in the fluid field remains a major challenge, often disrupting procedural rhythm an...

Sesamin as a Context-Dependent Redox Modulator: Interactions with Organelle Quality Control and Regulated Cell Death

Sesamin is a furofuran lignan in sesame with reported antioxidant, anti-inflammatory, metabolic, and anticancer activities. However, its biological effects vary according to exposure, metabolism, cellular state, and stress-response capacity. This review examines sesamin as a cont...

Altered saccade control reveals executive dysfunction in late-life depression

Late-life depression (LLD) is frequently accompanied by executive dysfunction, which is associated with poorer clinical outcomes but remains difficult to assess objectively in older adults. Saccadic eye movements provide a rapid and non-invasive approach for probing executive-con...

Structure-based identification and biological evaluation of a novel MAPKAPK2 inhibitor for pancreatic cancer

Pancreatic cancer remains a lethal malignancy with few effective treatment options. MAPKAPK2, a downstream effector of p38 signaling, represents a potential target for disrupting tumor survival pathways. Structure-guided computational screening has become an important strategy fo...

Glucagon-like peptide-1 receptor agonists are associated with an increased risk of repeat colonoscopy: a real-world retrospective cohort study

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) suppress intestinal motility, raising concerns regarding impaired bowel preparation quality during colonoscopy. Given the widespread use of these agents and inconsistent societal guidelines regarding their peri-procedural mana...

Flipped learning for leader empowering leadership among nurse leaders in residential aged care facilities: a pilot cluster quasi-experimental study

Empowering leadership by nurse leaders is crucial for creating positive workplace environments. However, no previous studies have investigated the effects of educational interventions utilizing a flipped-learning approach to cultivate empowering leadership behaviors among nurse l...

Outcomes of Laser Interstitial Thermal Therapy-Augmented Surgery in the Management of Subcortical Glioblastoma.

BACKGROUND AND OBJECTIVES: Subcortical glioblastomas present surgical challenges owing to their proximity to critical anatomy. In this study, we assessed the utility of laser interstitial thermal therapy (LITT) in the management of subcortical glioblastomas. METHODS: Clinical out...

Identification of holistic needs in people with chronic kidney disease

PURPOSE OF REVIEW: Chronic kidney disease (CKD) is a growing global health challenge with substantial physical, psychological, social, and practical consequences beyond impaired kidney function. This review examines the rationale for holistic needs assessment, summarizes availabl...

More-efficient water splitting utilizing heated-cooled active pure water with reduced hydrogen bonds

Within the realm of renewable energy technologies—particularly those centered on hydrogen evolution reactions (HERs) and oxygen evolution reactions (OERs)—noble metals have long been regarded as the archetypal catalytic materials. In recent years, however, research efforts have p...

Oncolytic virotherapy in cancer: cellular mechanisms, engineering strategies, and clinical translation

Abstract Oncolytic viruses (OVs) combine tumour-selective infection and replication with direct tumour-cell destruction and the capacity to induce antitumour immune responses. This review critically synthesises the cellular mechanisms, engineering strategies, preclinical developm...

Mixture-of-prompt experts for federated sentiment classification under non-IID data

Federated learning (FL) enables collaborative text classification while preserving data privacy, yet its performance can be degraded under non-IID data. This challenge is particularly severe in natural language processing, where client data may differ in linguistic style, topic d...

SLC35D1 Is Associated with Colorectal Cancer Progression, EMT-Related Phenotypes, and Immune Infiltration

Colorectal cancer (CRC) is one of the most common malignancies worldwide, and the prognosis of patients with metastatic disease remains poor. Solute carrier proteins participate in diverse cellular processes, yet the biological and clinical relevance of the SLC35D family in CRC r...

Associations and Discriminatory Performance of Anthropometric and Body-Shape Indices for Identifying Hypertension in Adults with Type 2 Diabetes in Malawi: A Cross-Sectional Study

Background: We evaluated the discriminatory performance of traditional anthropometric parameters and novel body-shape indices for identifying hypertension among adults with type 2 diabetes mellitus (T2DM) in Malawi. Methods: This was a multicenter cross-sectional study of 1356 ad...

Multidisciplinary perspectives on financial toxicity management in cancer survivorship care: an interpretive phenomenological study

To explore multidisciplinary professionals’ experiences in identifying, managing, and navigating financial toxicity among cancer survivors. A qualitative study grounded in Heidegger’s hermeneutic phenomenological approach was conducted at national cancer hospital in Indonesia. Fi...

Iliosacral Screw Fixation for Treating Sacral Fractures: A Modified Pedicle‐Guided Fixation Technique in Prone Position

ABSTRACT Background Sacral fractures are posterior pelvic ring injuries which mechanisms range from high‐energy trauma to low‐energy falls in osteoporotic patients. In surgical treatment, percutaneous approaches have demonstrated significant shorter operation time and less soft t...

Association between the overnight urinary cortisol-to-creatinine ratio and self-reported osteoporosis in community-dwelling Taiwanese adults: a population-based cross-sectional study

Chronic psychosocial stress is increasingly recognized as an important determinant of healthy aging and may contribute to osteoporosis through activation of the hypothalamic–pituitary–adrenal (HPA) axis. However, the association between physiological variation in endogenous corti...