Taipei Medical University

Myostatin‐dependent detrusor remodelling mediates contractility impairment in diabetic rats’ bladder – a maximal elastance analysis

Abstract The role of myostatin, an endogenous myokine mediating the pathological progression of myopathy, in contractility impairments of the chronically diabetic bladder remains unclear. This study examined whether maximal elastance (mE) reliably and validly assesses bladder con...

Psychometric properties of the paternal breastfeeding self-efficacy scale-short form: a confirmatory factor analysis of fathers in Taiwan

Abstract Background Fathers’ confidence in supporting their partners’ breastfeeding is crucial for successful breastfeeding outcomes. The paternal version of the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) is a globally recognised tool for measuring fathers’ perceived...

Age-related clinical characteristics and treatment patterns in hospitalized orbital cellulitis: a real-world federated database study

Orbital cellulitis is an uncommon but potentially severe infection that can cause vision-threatening complications and death. Differences in clinical characteristics and management between pediatric and adult patients remain incompletely characterized at the population level. Thi...

Gut Microbiota and Dietary Intake Across Training Phases in Competitive Long-Distance Runners: An Exploratory Longitudinal Study

Background/Objectives: In this exploratory longitudinal study, we examined dietary intake and gut microbiota across preparation, competition, and transition phases in competitive long-distance runners and explored microbial patterns associated with phase-specific dietary intake....

Glucagon-Like Peptide-1 Receptor Agonists and Neovascular Age-Related Macular Degeneration in Type 2 Diabetes: A Review of Emerging Clinical Evidence

Abstract Purpose of Review Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in the management of type 2 diabetes mellitus (T2DM) because of their established glycaemic, weight, cardiovascular, and kidney benefits. Recent observational evidence has raised...

Toward Clinically Trustworthy Pathology Foundation Models for Microsatellite Instability Prescreening in Colorectal Cancer

Pathology foundation models have recently emerged as powerful pretrained representations for computational pathology, yet whether complex downstream modeling is still necessary once frozen representations are evaluated under a common downstream framework remains insufficiently un...

Low-Supervision Asynchronously Monitored Home Rehabilitation for Adhesive Capsulitis: A Pilot Randomized Study

Background: Adhesive capsulitis often requires prolonged rehabilitation, and home exercise performed without supervision is difficult to document objectively. This pilot randomized trial evaluated the preliminary clinical effects and system-recorded engagement of a low-supervisio...

Subset-guided IL-15 expansion of NK cells amplifies antigen-specific CD4+ T cell immunity in melanoma

Abstract Background Natural killer (NK) cells comprise heterogeneous subsets with distinct developmental trajectories and effector functions; however, whether specific NK subsets can selectively coordinate adaptive antitumor immunity remains unclear. We identified a bone marrow-d...

Bioactive Gold Plasmonic Interfaces Meet Artificial Intelligence: Advancing Saliva‐Based Surface‐Enhanced Raman Spectroscopy Diagnostics

Bioactive gold plasmonic nanostructures are enabling non-invasive saliva diagnostics by amplifying weak Raman signals and converting complex biofluid chemistry into information-rich spectral fingerprints. This Review examines saliva-based Raman and surface-enhanced Raman spectros...

Comparative outcomes of Bernese periacetabular osteotomy in adolescents, young adults, and middle-aged adults

Aims: Bernese periacetabular osteotomy (PAO) is a well-established procedure for symptomatic hip dysplasia in adolescents and young adults. Its application in middle-aged patients remains debated due to concerns regarding complications and uncertain outcomes. This study evaluated...

Claudin 18 is not a biomarker for breast mucinous tumor

BACKGROUND: Breast mucinous cystadenocarcinoma (BMCA) is an exceptionally rare malignancy that may resemble mucinous neoplasms of the pancreas, ovary, lung and colorectum. Claudin 18 (CLDN18), particularly its gastric-associated isoform CLDN18.2, is an emerging therapeutic target...

Perioperative glucagon-like peptide-1 receptor agonist exposure and persistent postoperative opioid use among adults with type 2 diabetes mellitus: a propensity score-matched cohort study

Persistent postoperative opioid use remains an important perioperative concern, particularly in adults with type 2 diabetes, who may be more vulnerable to adverse postoperative recovery. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) may influence postoperative recovery thr...

Machine learning-based prediction of intraoperative desaturation risk in pediatric dental sedation using preoperative data

Dental sedation in children is widely used to reduce anxiety and facilitate successful dental procedures. However, intraoperative desaturation remains a significant safety concern. This study aimed to evaluate whether machine learning models using only readily available preoperat...

Genome-wide association study of estimated glomerular filtration rate using repeated measurements in the Taiwan Biobank

Background: Chronic kidney disease (CKD) is a major global public health issue, with genetic factors playing a significant role in kidney function. Although genome-wide association studies (GWAS) have identified numerous loci associated with estimated glomerular filtration rate (...

Sodium-glucose cotransporter-2 inhibitors, severe sepsis, and infection-related outcomes in patients with chronic kidney disease and type 2 diabetes

Background: Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) are vulnerable to infections. While sodium-glucose cotransporter-2 (SGLT-2) inhibitors provide established cardiorenal benefits, their effects on infection remain unclear. This study aimed to evaluat...

The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR‐TKIs treatment

Background Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) have substantially improved outcomes in non‐small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association...

A CD44-targeted PDA/ZnO redox-active nanocomposite that couples chemotherapy with mitochondrial stress and tumor immune remodeling

Bladder cancer therapy is frequently limited by inefficient drug retention and adaptive immune resistance within a hypoxic tumor microenvironment. Here, we report a CD44-targeted, fully synthetic nanocomposite (HPPZC) that converts chemotherapy into a mitochondria-associated ther...

Association of PR Interval with Illness Duration and Lymphocyte Count in Asian Adults with Bipolar Disorder

Objective: Individuals with serious mental illness are predisposed to a heightened risk of cardiac arrhythmias, with specific subtypes demonstrating a disproportionately high prevalence in Asian populations.An overlapping pathophysiology is hypothesized to underpin this clinical...

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data suggest that T cells depend on ROS for signal transduction. In this study, we show...

Transcriptional analysis of co-stimulatory molecules in ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease where T-cell dysregulation plays a pivotal role. A balance of co-stimulatory and co-inhibitory molecules governs the activation of T cells. This study aimed to investigate the mRNA expression profiles of the...