Taipei Medical University

Mistreatment, gender differences, and reporting behaviors among medical students in clinical training in Taiwan: a nationwide cross-sectional study

Mistreatment in the clinical learning environment remains a serious threat to medical students’ professional development and well-being, yet Taiwan lacks nationwide evidence to inform reform. This study aimed to examine the prevalence, patterns, and gender-specific features of mi...

Transcriptional analysis of co-stimulatory molecules in ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease where T-cell dysregulation plays a pivotal role. A balance of co-stimulatory and co-inhibitory molecules governs the activation of T cells. This study aimed to investigate the mRNA expression profiles of the...

Allograft and Recycled Autograft Reconstruction Following Resection of Bone Due to Osteosarcoma: A Systematic Review of Time to Union and Complications

Abstract Background: Osteosarcoma is the most common primary malignant bone tumor, predominantly affecting the femur, tibia, and humerus. Despite advances in surgical oncology, comprehensive evaluations of biological reconstruction methods remain limited, with existing literature...

The burden of suicide by paraquat poisoning in Taiwan (1987–2017): trends, geographic variations, and demographic characteristics

Pesticide self-poisoning accounts for 14%–20% of global suicides. Paraquat, a highly lethal pesticide, is involved in a considerable number of suicides in some countries. This study investigated the burden, trends, geographic variations, and demographic characteristics of pestici...

Enhancing nasal irrigation adherence through a multimodal health communication strategy: a phased improvement study

Abstract The adherence of chronic rhinitis patients to self-administered treatments is generally very low, which often presents a significant challenge in healthcare. The adherence of chronic rhinitis patients to regular nasal irrigation hygiene care is even lower. Therefore, in...

Sperm-specific fertility factors SMZ-1/2 promote FB-MO biogenesis and MSP filament assembly in C. elegans

Abstract In nematode sperm, motility is powered by polymerization of major sperm protein (MSP) into filaments assembled from a specialized organelle (FB–MO), but how filament formation begins is unclear. We identify two sperm-specific PDZ proteins, SMZ-1 and SMZ-2 (SMZ-1/2), that...

Polygenic architecture of childhood emotional and behavioral problems in East Asian youth: a multivariate genome-wide study

Abstract Background Emotional and behavioral problems in childhood, commonly classified as internalizing and externalizing symptoms, represent early manifestations of vulnerability to later psychiatric disorders. However, their genetic architecture remains largely characterized i...

Cross-Round Aggregation in Interactive Whole-Body PET/CT Lesion Segmentation: a Training-Free Study Alongside a Baseline Submission to autoPET V

autoPET V scores interactive whole-body PET/CT lesion segmentationby the area under the Dice-versus-interaction-round curve, so thetrajectory across rounds matters as much as the final state. Wesubmit the organisers’ nnU-Net interactive baseline withoutmodification, and report al...

Socioeconomic inequalities in underweight, overweight, and obesity among women in Malawi: a cross-sectional analysis of the 2024 Malawi demographic and health survey

Malnutrition remains a major public health concern among women in low-and middle-income countries, where undernutrition and overnutrition increasingly coexist. This pattern reflects rapid socioeconomic, dietary, and lifestyle transitions that disproportionately affect women of re...

Cross-Round Aggregation in Interactive Whole-Body PET/CT Lesion Segmentation: a Training-Free Study Alongside a Baseline Submission to autoPET V

autoPET V scores interactive whole-body PET/CT lesion segmentationby the area under the Dice-versus-interaction-round curve, so thetrajectory across rounds matters as much as the final state. Wesubmit the organisers’ nnU-Net interactive baseline withoutmodification, and report al...

Rebalancing mitochondrial dynamics restores succinate dehydrogenase activity and reduces succinate release in hepatocellular carcinoma

BACKGROUND: Dysregulated mitochondrial dynamics in cancer cells perturbs mitochondrial function and metabolism and promotes cancer progression. Its impacts on the electron transport chain, oxidative phosphorylation, redox balance, and glycolysis are well recognized. However, its...

Association Between Bladder Management Strategies and Symptomatic Urinary Tract Infections in Patients with Chronic Spinal Cord Injury: Lessons from a 5-Year Longitudinal Cohort

Background: Urinary tract infections (UTIs) are a leading cause of morbidity in patients with chronic spinal cord injury (SCI). This study examined the incidence of first and recurrent symptomatic UTIs in patients with chronic SCI and explored clinical factors associated with inf...

Association of low calf circumference and underweight with sarcopenia in older adults with chronic kidney disease: a cross-sectional study

Objectives This community-based, cross-sectional study aimed to evaluate the association of calf circumference and body mass index (BMI) with sarcopenia in older adults with chronic kidney disease (CKD).Methods: Community-dwelling adults aged ≥60 years were enrolled in New Taipei...

IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study

ABSTRACT Background Altered immunoglobulin G (IgG) glycosylation was implicated in various conditions, but its role in fibromyalgia (FM) remains unclear. This study investigated IgG glycosylation patterns in FM patients and associations between glycosylation changes and clinical...

The association between depression and frozen shoulder: A systematic review and meta-analysis

BackgroundFrozen shoulder (FS), commonly known as adhesive capsulitis, is a disabling musculoskeletal condition frequently accompanied by psychological distress. This meta-analysis aimed to evaluate the association between FS and depression.MethodsFor this meta-analysis, a system...

SGLT2 Inhibitors for Steatosis and Noninvasive Liver Markers in MASLD: A Meta-analysis of Randomized Trials

Abstract Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiometabolic dysfunction, yet liver-specific pharmacological options remain limited. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been proposed as potential the...

Prognostic value of tissue-based DNA methylation biomarkers in non-small cell lung cancer: a systematic review

Abstract Background Non-small cell lung cancer remains a leading cause of cancer-related death worldwide, with varied outcomes despite advances in therapy. Epigenetic modifications, especially DNA methylation, are crucial regulators of gene expression and have been linked to NSCL...

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial

Abstract Background SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymeras...

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...

Glycemic and Lipid Outcomes Associated with Bitter Melon Blood-Sugar-Modulating Protein and Metformin Use: A Translational Preclinical and Retrospective Study

Background/Objectives: Interactions between botanical supplements and standard antidiabetic therapies remain poorly understood. This study investigated the efficacy and mechanistic properties of a bitter melon blood-sugar-modulating protein (BMP) in relation to concurrent metform...