Taichung Veterans General Hospital

Localized Topical Melatonin Therapy Promotes Hair Regrowth in C57BL/6 Mice in Association with Wnt/β-Catenin Pathway Activation

Melatonin, a methoxyindole synthesized by the pineal gland, is secreted in response to photoperiodic cues relayed from the retina through an endogenous circadian oscillator within the suprachiasmatic nucleus. Consequently, melatonin secretion regulates the circadian rhythm. Melat...

Association of HBB gene variants with cardiometabolic and renal phenotypes in a Taiwanese genomic cohort: a cross-sectional study

Heterozygous mutations in the β-globin gene (HBB) define beta-thalassemia carriers (BTC), a state traditionally regarded as clinically silent. However, the systemic consequences of HBB variant carriage on metabolic and renal phenotypes remain incompletely characterized, particula...

Prevalence of dementia and BPSD in community-dwelling older adults with advanced care needs: a nationwide survey in Taiwan

Background Caring for people with both dementia and advanced care needs is complex. This study aimed to elucidate the prevalence of dementia and behavioral and psychological symptoms of dementia (BPSD) in patients receiving advanced care, including tube feeding, respiratory care,...

A population-specific genomic reference panel for Taiwan: NHRI-RP-1

Abstract Background To enhance the efficiency of identifying rare variants within the Taiwanese population and to support genome-wide association studies (GWAS) and imputation studies for genetic risk prediction in the Han population, we have developed the National Health Researc...

Risk of Dementia after initiation of GLP-1 RA versus long-acting insulin in patients with type 2 Diabetes mellitus

Background Recent studies suggest a decreased risk of dementia in patients treated with glucagon-like peptide-1 receptor agonist (GLP-1 RA). In this study, we compare the risk of dementia associated with GLP-1 RA versus long-acting insulin in adults aged over 50 years with type 2...