Stanford Health Care

AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes

Abstract Here we present AmpliconSuite, a toolkit for focal amplification analysis from cancer whole-genome sequencing that identifies extrachromosomal DNA (ecDNA), breakage–fusion–bridges and other amplification modes. Its ecContext module categorizes ecDNA structures to underst...

Science-wide mapping of institutions based on affiliated authors' impact and research integrity proxies

Abstract We aimed to generate institution-level data of indicators that may reflect, as proxies, the impact and the research integrity of the authors affiliated with them and that also adjust for institution size and scientific subfields where these authors work. We used the Scop...

Predicting Underweight Status in Infants With Cleft Lip and/or Palate in 10 US Children's Hospitals

ObjectiveTo develop and compare models predicting which infants with cleft lip and/or palate (CL/P) will be underweight at 4 months, using multicenter electronic health record data.DesignUsing data from birth to 3 months, we evaluated 63 anthropometric, clinical, healthcare-utili...

Hospital wastewater-based antimicrobial resistance epidemiology: a scoping review

Abstract Introduction: Wastewater-based epidemiology (WBE) offers pooled biological samples of defined populations, complementing clinical surveillance for infectious diseases. Hospitals are hotspots for antimicrobial resistance (AMR). We performed a scoping review assessing hosp...

RINGSIDE Phase II Study of Varegacestat for Treatment of Desmoid Tumors: A Randomized Dose-Finding Clinical Trial

PURPOSE Desmoid tumors (DTs) are rare, often locally aggressive, connective tissue neoplasms with limited effective treatment options. We evaluated the safety and efficacy of varegacestat, an oral gamma-secretase inhibitor. METHODS RINGSIDE phase II was an open-label, randomized,...

Treatment of distal femoral malignant bone tumors with freezing tank–assisted pedicle-freezing: a retrospective study of 31 patients

Biological reconstruction with recycled autografts is an established option for limb salvage after bone tumor resection, but complications such as graft failure and nonunion remain concerns. Pedicle freezing was introduced in 2010 and showed potential in reducing nonunion. Howeve...

Dosing and delivery of bacteriophage therapy in a murine wound infection model

Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant Pseudomonas aeruginosa. However, dosing and delivery strategies for phage therapy remain underdeveloped. In a mouse wo...

COVID-19 lockdown and coverage of maternal health and nutrition care in rural West Bengal, India: a single interrupted time-series analysis

Abstract While COVID-19 lockdowns globally disrupted healthcare, the extent of changes in India’s maternal health and nutrition services coverage in rural settings requires further empirical investigation. Utilizing data from 57,371 pregnancies recorded between January 2012 and D...

Artificial Intelligence–Based Detection of ARIA on MRI During Alzheimer Disease Therapy: Expert Opinion on Responsible Clinical Integration

Amyloid-targeted monoclonal antibody therapies have introduced a new era in the treatment of early Alzheimer disease. However, their use has increased the importance of detecting and monitoring amyloid-related imaging abnormalities (ARIA) on MRI, as such findings may influence tr...

Parent–Clinician Communication and End‐of‐Life Preparation in Pediatric Oncology: An Explanatory Sequential Mixed‐Methods Study

PURPOSE: Parental preparedness for their child's end of life (EOL) may lessen perceived suffering and prolonged grief. Although clear communication may support parental preparedness, the specific communication components that influence this process remain poorly understood. This...

Humans: Intertwined with life and the basic elements in the Anthropocene biosphere

Abstract The notion of people and nature as intertwined and embedded in the biosphere is gaining traction in contemporary scientific discourses. But what does it mean for a human being to be intertwined? Here, we explore this question through two lenses: looking at the human body...

Unacknowledged Burdens and Clinical Assets of BIPOC Genetic Counseling Students: Qualitative Evidence to Inform Supervision

As the genetic counseling profession works to diversify its predominantly white workforce, understanding the experiences of Black, Indigenous, and People of Color (BIPOC) students is central to equity efforts. While BIPOC students bring invaluable cultural and linguistic diversit...

Founding the Pain Medicine Academy of Advanced Practice Providers

Globally and across the United States there is a demand for pain management services, however specialty trained clinician shortages continue to rise. Advanced practice providers have demonstrated clinical excellence in providing pain management. Pain medicine professional organiz...

TRANCE is a unique marker of chronic pancreatitis in children

BACKGROUND Elucidating immune signals through well-defined cohorts of pediatric acute pancreatitis (AP) and chronic pancreatitis (CP) patients is critical. This study aimed to evaluate plasma chemokine and cytokine levels in pediatric participants with CP, compared with AP and he...

Tuning Viscoelasticity of Dynamic Covalent Hydrogels for Human Tissue Modeling

ABSTRACT The development of three‐dimensional (3D) in vitro tissue culture models is critical for biomedical research. Hydrogel‐based systems have become preferred scaffolds for 3D models, as they have tunable viscoelastic properties, which are well‐known to influence cell morpho...

Full Plate Living Evaluation and Case Series

Dietary interventions can improve cardiometabolic health, however, affordability, sustainability, and efficacy remain a challenge. Full Plate Living (FPL) is a free, virtual, research-based, experience-centered nutrition program that has been shown to improve health. Here, we des...

Prolonged treatment-free remission after venetoclax in combination with a hypomethylating agent in acute myeloid leukemia with inv(16)

Core binding factor acute myeloid leukemia (CBF-AML)—defined by t(8;21) or inv(16) chromosomal rearrangements—is classified as favorable-risk disease per the European LeukemiaNet 2022 risk model and is typically treated with intensive chemotherapy. Patients unsuitable for intensi...

Optimizing Informed Consent for Australian Newborn Bloodspot Screening and Research: Consensus Workshop Insights and Recommendations

Informed consent is fundamental to Australian newborn bloodspot screening (NBS), but emerging genomic screening technologies pose new challenges to clinical care and research. Optimizing consent processes is necessary to support ethical practice and maintain public trust as NBS e...

Prevalence, Incidence and Mortality of Chronic Kidney Disease in Type 1 and Type 2 Diabetes—A Nationwide Danish Register‐Based Cohort Study

ABSTRACT Aims Chronic kidney disease (CKD) remains a leading complication of diabetes, and understanding population‐level trends is crucial for prevention and healthcare planning. We examined national trends in CKD prevalence, incidence, and mortality among people with diabetes....

Watson's Caring Science-Based Interventions in Holistic Nursing and Health Care: A Scoping Review of Patient Satisfaction and Clinical Outcomes

PurposeTo map and summarize the literature on Watson's Caring Science Theory-based interventions in relation to patient satisfaction and clinical outcomes. Watson's Caring Science Theory provides a foundational framework for relational and holistic nursing care, yet evidence on p...