Sorbonne Paris Cité

Beyond the standardization trap: A critical quantitative perspective on disabilities across transit and public spaces

In recent years, there has been renewed interest in the discrepancies between conceived and perceived accessibility. A particularly recurrent critique of accessibility as conceived through planning and measurement standards is that it tends to misjudge the actual difficulties exp...

Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...

Uneven TCR chain pairing constraints govern epitope recognition

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope recognition, the extent to which a single chain dictates specificity remains unclear...

Direct evidence of apex–hypha interactions during vegetative growth of fungal thallus via comprehensive network and trajectory extraction

Abstract The mycelium of a filamentous fungus is a growing, branching network of numerous entangled hyphae exhibiting polarized apical growth. Expansion occurs during the vegetative phase from a single ascospore, driven by the need to explore and occupy surrounding space—limiting...

The algebraic structures of social organizations: the operad of cooperative games

The main goal of this paper is to settle a conceptual framework for cooperative game theory in which the notion of composition/aggregation of games is the defining structure. This is done via the mathematical theory of algebraic operads: we start by endowing the collection of all...

Septin architecture dictates size-dependent diffusion barriers on biomimetic membranes

Abstract Septins are cytoskeletal filaments bound to the inner leaflet of the plasma membrane, essential for cell division. They are involved in the formation of diffusion barriers for membrane-bound components. Whether septins directly function as barriers or as part of a broade...

Effects of equine-assisted services in psychiatric disorders: a systematic review

For several years, psychosocial rehabilitation programs have been offered to psychiatric patients as a complement to pharmacological treatment. These programs include Equine-Assisted Services (EAS). Horses are social, highly attentive, and emotionally sensitive animals, making eq...

Poincaré inequality and quantitative De Giorgi method for hypoelliptic operators

We propose a systematic approach based on trajectories to prove a Poincaré inequality for weak non-negative sub-solutions to hypoelliptic equations with an arbitrary number of Hörmander commutators, both in the local and in the non-local case. As a consequence, we deduce the weak...

Real-World Use of Adjuvant Nivolumab for Resected Stage III–IV Melanoma: 2-Year Analysis of AdjuMel

Following the positive findings of the phase 3 CheckMate 238 trial, adjuvant nivolumab has become a standard therapy in patients with completely resected stage III–IV melanoma. The prospective, ongoing AdjuMel study is evaluating the real-world use, effectiveness, and safety of a...

Oral health, oral follow-up and infectious risk management of rheumatoid arthritis patients on anti-TNF drugs: a survey of a French e-cohort

Abstract Background As periodontitis is a recognized risk factor for rheumatoid arthritis (RA), it should be adequately treated before the initiation of biologic disease-modifying antirheumatic drugs (bDMARDs), along with any concomitant acute oral infection. bDMARDs remains a co...

The Challenge of Meaningful Comparison: Assessing the Relation Between Social Comparison Orientation and Meaning in Life

Social comparison processes play a central role in social cognition, but their relation to meaning in life remains unclear. We conducted an integrative analysis of three online studies with American, Indian, Peruvian, and French participants. After harmonizing the study-specific...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Venular-centered thrombo-inflammation drives microvascular failure after arterial recanalization in acute mesenteric ischemia

Abstract Background Acute mesenteric ischemia (AMI) remains associated with high mortality despite prompt revascularization, suggesting that downstream ischemia–reperfusion injury contributes to poor outcomes. However, the microvascular mechanisms underlying this process are not...

Lie structures in homotopy and isotopy calculi

Abstract We establish compatibility of Lie structures that appear in homotopy calculus of functors and isotopy calculus of embeddings. On one hand, we give a new proof of the Johnson–Arone–Mahowald result describing the layers of the Goodwillie tower of the identity functor, and...

Miscompartmentalization of microbiota-derived TMAO is a reversible driver in autism spectrum disorder

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder. Unlike genetics and gut dysbiosis, ASD appears to be homogeneous when considering tryptophan metabolism. Following these findings, we found that ASD was associated with the miscompartmentalization of t...

Constitutive natural killer cell features associated with post-treatment control of SIV infection in the pVISCONTI study

Abstract Post-treatment HIV controllers (PTC) offer a unique opportunity to uncover the determinants of durable remission after antiretroviral therapy (ART) interruption. Here, using six PTC and six post-treatment non-controllers from the pVISCONTI study in cynomolgus macaques, w...

Evidence of a massive accretion event 1.8 billion years before the Gaia-Sausage-Enceladus merger

Abstract The merger history of the Galaxy has been traced back firmly to a redshift of 2 (10 billion years ago). While evidence for the existence of at least one more substantial merger before this time has been presented, its interpretation is yet to be fully established. Here w...

Comparative performance of CMV IgM and IgG avidity assays for diagnosing a recent primary infection in the first trimester of pregnancy

First-trimester (T1) cytomegalovirus (CMV) screening relies on IgG, IgM, and IgG avidity testing, but assay performance may vary according to the infection timing. To evaluate the ability of two IgM and three IgG avidity assays to detect maternal primary CMV infection (MPI) occur...

Imaging in France: 2026 Update

France has seen significant advancements in radiology in recent years, driven by innovations in research and clinical practice. French groups have developed innovative imaging techniques and artificial intelligence applications in the field of diagnostic imaging and interventiona...

Frailty before disease onset: risk of mortality and chronic conditions in disease-free middle-aged adults

Abstract Frailty, defined by multisystem physiological decline and heightened vulnerability to stressors, is typically associated with aging and chronic disease. However, its relevance in apparently healthy individuals remains poorly understood. Identifying frailty in this popula...