Sorbonne Paris Cité

Functional central limit theorem for topological functionals of Gaussian critical points

We consider Betti numbers of the excursion of a smooth Euclidean Gaussian field restricted to a rectangular window, in the asymptotics where the window grows to Rd. With motivations coming from topological data analysis, we derive a functional central limit theorem where the vary...

Deterministic mean field games on networks and related optimal control problems

We study deterministic mean field games and related optimal control problems, with finite time horizon and a network as state space. An agent controls her velocity and, when she occupies a vertex, she can either remain still or enter any adjacent edge. The costs are continuous in...

MARS-RNA: An Automated Pipeline for Correlating RNA Molecular Dynamics Trajectories with Chemical Probing Data

Abstract Ribonucleic acid (RNA) molecules fold into complex, highly dynamic three-dimensional conformational structures that govern their biological activities. Chemical probing methods, such as SHAPE (selective 2′-hydroxyl acylation analyzed by primer extension), provide structu...

Two-dimensional topological quantum chemistry and catalog of topological materials

Two-dimensional (2D) topological materials host symmetry-protected, disorder-robust edge states central to quantum technologies. Yet they remain scarce compared with their 3D counterparts. We adapted the topological quantum chemistry formalism to layer groups and studied the band...

Are older adults in China living longer happy years? A cohort-based multistate analysis, 2002–2018

Abstract China’s rapid population ageing raises the question of whether added years of life are also happy years. Using data from the Chinese Longitudinal Healthy Longevity Survey (2002–2018), we applied a cohort-based multistate life table method to estimate partial-cohort happy...

2D theoretically twistable material database

The study of twisted two-dimensional (2D) materials, in which twisting layers create moiré superlattices, has created opportunities for investigating topological phases and strongly correlated physics. The broader potential of a seemingly infinite set of twistable 2D materials re...

Symptomatic primary aortic mural thrombus: Findings after 6 months of oral anticoagulation

Background: Primary aortic mural thrombus (PAMT) is defined by an aortic thrombus in the absence of underlying aortic disease. Management relies on anticoagulation, with or without surgery, but optimal treatment duration remains uncertain. We evaluated clinical and radiological o...

Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants

Importance Probiotics are reported to benefit preterm infants, but population-based clinical evidence is limited. In 2020, the Swedish Neonatal Society issued a national recommendation to supplement very preterm infants (28 weeks 0 days’ to 31 weeks 6 days’ gestation) with probio...

WHOLE-GENOME SEQUENCING AS A FIRST-TIER TEST FOR SCHIZOPHRENIA AND BIPOLAR DISORDER: THE FRENCH CLINICAL IMPLEMENTATION

The integration of genomic medicine into healthcare systems represents a major translational challenge. In France, the Plan France Médecine Génomique 2025 (PFMG2025) was designed to directly embed whole-genome sequencing (WGS) into routine clinical care through a nationwide infra...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

Exploring the potential of cluster analysis in identifying disease phenotypes in CPPD: Moving from intuition to insight

BACKGROUND: Calcium pyrophosphate deposition (CPPD) disease is a heterogeneous condition and is frequently misdiagnosed due to the different clinical presentations and variable disease progression. Aim of this study is to identify clinical phenotypes of CPPD disease by integratin...

Differentiable latent structure discovery for interpretable forecasting in clinical time series

Abstract Background Timely, uncertainty-aware forecasting from irregular electronic health records (EHR) can support critical-care decisions, yet most approaches either impute to a grid or sacrifice interpretability. We introduce StructGP, a continuous-time multi-task Gaussian pr...

Not speaking my language: playback experiments reveal early-orphaned human-reared adult cheetahs lack interest in species-specific vocalizations

Abstract Early adult models, particularly the mother, play an essential role in tuning perception to build the multimodal representation of species-specific social signals, especially in mammals. Therefore, early maternal loss adversely impacts social integration in mammals. More...

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

Local and Systemic Risk Factors of Dental Biofilm‐Induced Gingivitis and Their Control: A Systematic Review

ABSTRACT Objectives To identify local and systemic risk factors/indicators for dental biofilm‐induced gingivitis (DB‐GI) and to summarize evidence for their control. Methods A systematic review was undertaken following Preferred Reporting Items for Systematic Review and Meta‐Anal...

Resolving Peptide-Based Supramolecular Architecture Emerging at Reactive Copper/Water Interface

Abstract Understanding how molecular interactions evolve into ordered architectures at reactive solid/liquid interfaces remains a major challenge because surface reactivity can profoundly influence adsorption mechanisms. In such systems, multiple interfacial processes, including...

Mean-Field Limit for Stochastic Control Problems under State Constraint

Abstract. We study the convergence problem of mean-field control theory in the presence of state constraints and nondegenerate idiosyncratic noise. Our main result is the convergence of the value functions associated to stochastic control problems for many interacting particles s...

Normal approximation for subgraph counts in age-dependent random connection models

Abstract We study normal approximation of subgraph counts in a model of spatial scale-free random networks known as the age-dependent random connection model . In the light-tailed regime where only moments of order left parenthesis 2 plus epsilon right parenthesis ( 2 + ε ) $(2+\...

Factors influencing access to healthcare for the indigent in Senegal

Equitable access to health services remains a major challenge to achieving universal health coverage (UHC). In Senegal, the National Family Safety Net Program (PNBSF) aims to reduce vulnerability among poor households through cash transfers and free enrolment in community-based h...

Effect of oxygen ion irradiation on the visible, infrared, and Raman spectra of Phobos candidate materials: implications on the space weathering by Martian atmosphere-derived ions

Abstract The origin of Martian satellites is still under debate. Nevertheless, such information could give insights into the evolution of the Martian system and planetary formation processes. To address these questions, MMX (Martian Moons eXploration) will conduct spectroscopy (v...