Shandong University

Short-lived halogen sources and chemistry in the Community Earth System Model v2 (CESM2-SLH)

The implementation of short-lived halogen (SLH) sources and atmospheric chemistry in the Community Earth System Model v1 (CESM1) allowed to study the influence of SLH chemistry on the oxidative capacity of the atmosphere and, consequently, the Earth's climate. In this manuscript,...

Fluid–substrate coupled controls on mineral‑phase selection in the Kunlun hydrothermal system

Abstract Mineral precipitation at submarine hydrothermal vents transfers redox‑sensitive elements from the lithosphere to the ocean. However, conventional plume and sediment‑trap sampling poorly preserves particle‑scale signatures generated at reactive interfaces, hindering robus...

Mesoporous fluoridated hydroxyapatite nanorods as a multifunctional platform for potential cancer-induced bone defect repair

Objective For cancer-induced bone defects, cancer therapy is as important as tissue repair. Therefore, multifunctional materials with both anticancer and regenerative properties are urgently needed. Methods Here, we prepared mesoporous FAp (MFAp) nanorods with uniform morphology...

The application value of artificial intelligence in medical imaging: foundations, progress, and challenges

Abstract Artificial intelligence (AI) is rapidly transforming medical imaging, reshaping the field as it does everyday life. As imaging data grow in complexity and clinical workloads continue to rise, AI has become increasingly essential for improving diagnostic efficiency and pr...

Phytochemical Analysis and Biological Activities of Essential Oils from Leaves and Stems of Dicranopteris pedata (Houtt.) Nakaike

Dicranopteris pedata (Houtt.) Nakaike (family Gleicheniaceae) is a widespread fern species commonly found in tropical and subtropical areas and has long been employed in folk remedies for its various therapeutic properties. This study aimed to evaluate the phytochemical profiles...

Prognostic value of baseline serum lactate dehydrogenase in EGFR-mutant lung adenocarcinoma treated with first-line EGFR-TKI monotherapy

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are standard first-line treatment for patients with sensitizing EGFR-mutant lung adenocarcinoma; however, treatment outcomes remain heterogeneous and acquired resistance eventually develops in most patients...

Characterization of Polaribacter formosus sp. nov. and Polaribacter salmoneus sp. nov. with Comparative Genomic Analysis of the Genus Polaribacter

Two novel Gram-negative, rod-shaped, carotenoid-pigmented strains, Z022T and Z014T, were isolated from the viscera of abalone, Haliotis discus hannai, in Weihai, China and from coastal sediment samples collected at the Antarctica Great Wall station, respectively. Phylogenetic ana...

Systemic inflammation response index

This study aims to explore the association between the systemic inflammation response index (SIRI) and the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) by retrospectively analyzing clinical data derived from the Medical Informati...

Investigating the Effects of a CCR3 Antagonist and SP-A Eosinophil Suppressor Tetrapeptide-Transduced Mesenchymal Stem Cells in Allergic Asthma

Allergic asthma (AA) is a consequential global health challenge immunologically characterized by type 2 inflammatory responses and no definite treatment, demanding novel therapeutic strategies. Eosinophils are the main orchestration of AA, whose recruitment and activation depends...

Contamination Means Overestimation? A Fine-Grained Empirical Study in Code Intelligence

In recent years, code intelligence has gained increasing importance in the field of automated software engineering. Meanwhile, the widespread adoption of Pretrained Language Models (PLMs) and Large Language Models (LLMs) has raised concerns regarding data contamination and its po...

CausalRepair: Bridging the Causality Gap in Large Language Model-Based Automated Program Repair via Dual-Slicing

Automated Program Repair (APR) aims to automatically fix buggy programs. In recent years, with the rapid advancement of Large Language Models (LLMs), LLM-based APR techniques have achieved significant progress. Despite their potential, the effectiveness of LLMs relies heavily on...

The Unseen Delta: Characterizing the Compiler Optimization Landscape via Top-Down Differential Analysis

Compiler optimizations are essential for achieving high performance in modern software. However, recent studies highlight the persistence of performance bugs, i.e., subtle defects where the compiler generates functionally correct but computationally inefficient code, leading to s...

Asymmetric Divergent Synthesis of Miophytocen D, Roridin E, Verrucarin J, and Verrucarol

Abstract Herein, we report a divergent asymmetric synthesis of miophytocen D, roridin E, verrucarin J, and verrucarol. The synthesis features an exo-selective Diels–Alder cycloaddition, a biomimetic chemoselective oxacyclization for tetrahydropyran ring assembly, a conformation-c...

Microfluidic-based high-throughput isolation enhances the recovery of novel strains and diversity from Arctic soil microbiome

ABSTRACT Microbial cultivation remains essential for understanding the physiology, ecology, and biotechnological potential of environmental microbes, yet conventional plate-based methods (CPM) recover only a minute fraction of the environmental microbiome. Polar regions, particul...

Continuous Heterodyne Microwave Sensing With van der Waals Spin Defects

ABSTRACT Quantum sensing with solid‐state spin defects provides a powerful approach for microwave‐field detection, but conventional sensing protocols are often limited by narrow detection bandwidths. Here, we demonstrate continuous heterodyne microwave sensing using spin defects...

Spacing-Dependent Electrostatic Shielding and Early Positive Streamer Development in Twin Grounded Emitters: A 3D to 2D Reduced-Order Mapping

Geometric shielding in multi-emitter configurations modifies the near-tip ionisation environment, whereas resolving each geometry with a full three-dimensional transient discharge model is computationally demanding. Here, the three-dimensional electrostatic field of two grounded...

Blastocyst Diameter and Collapse as Predictors of Live Birth Following Single Blastocyst Transfer: A Time-Lapse Morphometric Analysis.

OBJECTIVE: To investigate whether blastocyst diameter measured immediately prior to transfer and the occurrence of blastocyst collapse predict live birth outcomes after single blastocyst transfer (SBT). METHODS: This retrospective cohort study included 476 patients undergoing the...

Oral and oropharyngeal bacterial microbiota in children with obstructive mouth breathing: a pilot cross-sectional study

Obstructive mouth breathing (OMB) is a common pediatric condition associated with oral and systemic health problems. OMB may alter the oral and oropharyngeal environment through mucosal dryness, reduced salivary clearance, altered airflow and gas exchange, and impaired local muco...

Over 20% Efficiency in As–Cast Organic Solar Cells Enabled by Flory–Huggins Parameter Engineering

ABSTRACT The realization of high–efficiency as–cast organic solar cells (OSCs) represents a key step toward simplified processing and scalable fabrication for commercialization. However, achieving high–performance as–cast devices remains challenging because it demands delicate ba...

Structure-Guided Hybrid GCN−Transformer Framework for Enzyme Optimal pH Prediction

Abstract Accurate prediction of enzyme optimal pH (pHopt) is fundamental to biocatalyst engineering, pharmaceutical development, and process optimization, yet developing a reliable computational method remains challenging. To address this limitation, we present trPHopt, which is...