Shandong University

BRD4-S reprograms glutathione metabolism to reduce ferroptosis sensitivity and limits oxaliplatin response in gastric cancer

Abstract Background Bromodomain-containing protein 4 (BRD4) exists as distinct isoforms with potentially different biological functions, but their roles in ferroptosis and chemotherapy response in gastric cancer (GC) remain poorly understood. Here, we investigated the isoform-spe...

Geometry-driven thermal–fluid topology optimization using B-spline geometric primitives

Topology optimization has been widely applied to thermal–fluid design, particularly for channel-based systems. However, many conventional approaches rely on implicit density-field representations, making it difficult to preserve geometrically interpretable channel features and di...

Brassinosteroids improve nitrogen utilization by antagonizing BIN2-mediated SnRK1 activation

Nitrogen is an essential nutrient for plant growth and development, and is central to increasing crop yield. Brassinosteroids (BRs) and their analogs are widely used in agriculture to enhance crop yields and improve nitrogen utilization, yet the underlying mechanism remains fragm...

MRI-based intratumoral and peritumoral heterogeneity for predicting intracranial progression in EGFR-mutant lung adenocarcinoma patients with treatment-naive brain metastases receiving first-line third-generation EGFR-TKIs

To develop and externally test a multiparametric MRI habitat-based framework integrating intratumoral heterogeneity (ITH), peritumoral heterogeneity (PTH), and clinical characteristics for predicting intracranial progression in patients with EGFR -mutant lung adenocarcinoma and d...

Urinary Exposure to Chemical Additives in Healthy Older Adults in China: Characterization, Determinants, and Health Risks from the China BAPE Study

Abstract Polymer- and rubber-associated chemical additives are widely used in consumer products and are increasingly recognized as emerging contaminants of concern; however, urinary biomonitoring data for older adults remain scarce. Accordingly, the objectives were to characteriz...

Relational Consensus and Gendered Differentiation: The Ranked Structure of Ideal Partner Preferences Among Chinese University Students

Relational qualities are highly valued in ideal partners, while women and men differ in the weight they attach to resources and physical attractiveness. It remains unclear whether these patterns reflect competing ideals or different emphases within a broadly shared preference hie...

Development of Long-Acting Teriparatide Analogues through Iterative Peptide Scanning and Site-Specific Modification by Serine/Threonine Ligation

Abstract Teriparatide, the only FDA-approved osteoanabolic drug for osteoporosis, suffers from poor metabolic stability and requires frequent subcutaneous injections, leading to suboptimal patient compliance. To find optimized teriparatide derivatives, we herein report an iterati...

Laparoscopic−assisted versus purely transanal Soave procedures for Hirschsprung disease in children aged ≤ 4 years: an age−stratified retrospective study

Laparoscopic−assisted and purely transanal Soave procedures are commonly used for Hirschsprung disease, but whether their comparative outcomes differ according to age remains uncertain. This single−center retrospective cohort study included 188 children aged ≤ 48 months who under...

Time-optimal trajectory planning based on dynamic constraints for a handling robot with kinematic redundancy

Purpose This paper proposes a time-optimal trajectory planning method for high-speed and heavy-load handling robots with kinematic redundancy, aimed at significantly increasing the efficiency of stamping production lines. Design/methodology/approach Kinematic and dynamic models o...

Modeling of Surface Tension Isotherms with an Extremum for Binary Liquid Mixtures

Abstract Anomalous (or aneotropic) surface tension (σ) isotherms with a distinct extremum (minimum or maximum) have been reported for numerous binary liquid mixtures, yet a feasible model for describing such aneotropic behavior remains lacking. In this work, by coupling the surfa...

TXNIP/PINK1 Mitophagy Axis Promotes Th17 and Bone Loss in Diabetic Periodontitis

Introduction and Aims Diabetic periodontitis (DPD) is characterised by severe alveolar bone loss refractory to conventional therapies. Hyperglycaemia drives Th17-mediated inflammation, yet the underlying immunometabolic mechanism remains unclear. This study aimed to elucidate the...

Research Progress on Offline Defect-Detection Technologies for Selective Laser-Melting Parts

Selective laser melting (SLM) is recognized as one of the most promising metal additive manufacturing technologies for industrial deployment and has been applied to fabricate precision components for high-end equipment in sectors including aerospace and biomedicine. Nevertheless,...

Intestinal microbiota-associated LysoPC(16:0) promotes endometriosis via PPARγ-mediated M2 macrophage polarization and IL-10 secretion

Both gut microbiota dysbiosis and altered pelvic immune microenvironment have been linked to endometriosis (EM), but the metabolites connecting the two remain undefined. Combining 16S rDNA sequencing with non-targeted metabolomics in a murine EM model, we found altered gut microb...

Mechanical Irreversibility and Strength Overcompensation in a Gypsum Dehydration–Rehydration Cycle

Abstract Dehydration–rehydration reactions of hydrous minerals modify rock strength, fluid transport, and deformation in reactive geological environments. Although dehydration‐induced weakening is widely studied, the mechanical consequences of subsequent rehydration remain poorly...

Healthy lifestyle as a protective factor against the risk of gastroesophageal reflux disease: Prospective population cohort analysis

Background Lifestyle modifications are recommended by American Gastroenterological Association (AGA) for managing gastroesophageal reflux disease (GERD), a significant health issue; but evidence is scarce. This study aims to investigate the longitudinal association between health...

Numerical investigation of flow and heat transfer characteristics of supercritical CO2 in metal foam for Brayton cycle heat exchangers

The supercritical CO 2 (sCO 2 ) Brayton cycle offers great potential for compact, high-efficiency power systems, but conventional heat exchangers struggle to meet extreme thermal demands under high-parameter conditions. Open-cell metal foams offer a promising solution for heat tr...

Molecular dynamics insights into bubble nucleation of liquid sodium on hybrid wettability surfaces: Temperature dependence and scale-induced site inversion

Molecular dynamics simulations were performed to investigate the bubble nucleation characteristics of liquid sodium on hybrid-wettability surfaces composed of alternating hydrophilic and hydrophobic stripes. Wall temperature T wall and stripe width w were varied independently to...

Microstructure and Wear Performance of Ni-Based Laser Cladded Coatings Reinforced with Different ZrC Contents on Structural Steel

To address surface scratching and wear failure of 45 steel piston rods under high-stress service conditions, Ni60A composite coatings reinforced with different zirconium carbide (ZrC) contents (30 wt%, 40 wt%, and 50 wt%) were prepared on 45 steel substrates via laser cladding. T...

Evolutionary Characteristics and Obstacle Factors of the Water–Energy–Food Nexus in Resource-Based Regions: A Case Study of Daqing, China

The water–energy–food (WEF) nexus is central to regional sustainable development, particularly in resource-based regions (RBRs) facing resource depletion and ecological strain. While existing studies have examined internal WEF linkages and extended the framework to include extern...

Localized Lipid Delivery Regulates Exogenous Lipid Behavior at Persistent Defects in Stratum Corneum Lipid Bilayers

Abstract Disruption of the stratum corneum (SC) lipid matrix compromises the skin barrier function; however, the molecular mechanisms by which exogenous lipids promote its repair remain unclear. Here, all-atom molecular dynamics (MD) simulations were employed to investigate how i...