Shandong Provincial Hospital

ID4 enhances ferroptosis sensitivity in gastric cancer by promoting ubiquitination degradation of GPX4

Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide, presenting a serious threat to human health due to its high fatality rates and incidence. Ferroptosis, as a novel form of programmed cell death, demonstrates significant potential in cancer therapy. The...

Familial tailgut cysts in two sisters presenting with sacral dimple sign: a case report

Tailgut cysts are rare congenital cystic lesions arising from remnants of the embryological postanal primitive gut. Familial clustering of tailgut cysts has been rarely reported, and the association with sacral dimple sign as an early diagnostic indicator remains underexplored. W...

Targeting intratumor microbiota in oral squamous cell carcinoma from potential mechanisms to future opportunities

Abstract Oral squamous cell carcinoma (OSCC) is the predominant subtype of oral cancer, accounting for over 90% of all cases, with high incidence and poor long-term survival. Advances in the etiology of OSCC and ongoing characterization of the microbiota have revealed a strong as...

6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes

levels, downregulation of GPX4, and accumulation of lipid peroxidation. A genome-wide CRISPR/Cas9 knockout screen identified EXOC7 as a critical mediator of 6PPD-Q-induced podocyte injury. Mechanistically, 6PPD-Q disrupted the E3 ubiquitin ligase activity of MARCHF2, leading to r...

OMVs of Pseudomonas aeruginosa extracted from chronic suppurative otitis media trigger ototoxicity: possible relation to activation of NLRP3 inflammasome

Abstract Background Chronic suppurative otitis media (CSOM) can lead to sensorineural hearing loss (SNHL), but the underlying mechanisms remain incompletely understood. This study aimed to investigate whether the outer membrane vesicles (OMVs) from Pseudomonas aeruginosa ( P.aeru...