Shandong Provincial Hospital

Targeting p38α promotes Parkin-mediated mitophagy to attenuate severe acute pancreatitis via suppressing the mtDNA/cGAS-STING signaling pathway

Abstract Severe acute pancreatitis (SAP) is a life-threatening acute inflammatory disorder characterized by systemic inflammation and high mortality, for which specific targeted therapeutic strategies are still severely lacking in clinical practice. Mitochondrial dysfunction and...

A fully automated deep learning pipeline system for carotid plaque segmentation and vulnerability classification on multi-contrast MRI: a multicenter study

Abstract Background Carotid vulnerable plaque rupture is a major cause of ischemic stroke. However, accurate identification of high-risk plaques using medical images heavily relies on radiologists’ expertise. This study aimed to develop an artificial intelligence (AI) system for...

Development of a patient journey map for diabetic retinopathy: exploring evidence from qualitative research

The World Health Organization has emphasized people-centered health, shifting focus from disease to patient needs. Patient Journey Mapping has emerged as a valuable methodological approach to support healthcare and nursing management by visualizing patient experiences and identif...

NAT10-mediated ac4C modification and CEBPB-mediated transcriptional activation converge on CBS to promote malignant progression in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignant tumor, and its development mechanism remains unclear. Ferroptosis, as a novel regulatory mode of cell death, plays an important role in tumor regulation. However, the function of cystathionine-β-synthase (...

A Piezoelectric Microtool for In Vitro Elastic Modulus Measurement and Hepatocellular Carcinoma Boundary Identification

Accurate identification of tumor boundaries is crucial for effective local treatment and protection of surrounding healthy tissue. However, current methods for rapidly characterizing local tissue biomechanical properties remain limited. In this study, we present a novel MEMS-inte...

Breviscapine Blunts Hypertrophic Scar Formation via Dual Suppression of TGF-β1 Signaling and the Akt-mTOR Pathway

Background: Hypertrophic scar (HS) arises from aberrant cutaneous wound healing, characterized by uncontrolled myofibroblast proliferation and disproportionate extracellular matrix (ECM) accumulation. Breviscapine, a natural compound, suppresses inflammation and fibrosis. This st...

Early-life recurrent antibiotic use and risks of adult kidney cancer and sex-specific cancers: a prospective cohort study in the UK Biobank

There is little evidence about the associations of long-term or recurrent antibiotics use (LRAU) during early life with cancer risk. Our study aimed to assess the associations via Cox proportional hazards regression, using data from the UK Biobank (UKB). The main outcomes were th...

Low-dose interval radiotherapy combined with tirelizumab and SOX chemotherapy neoadjuvant therapy for locally advanced gastric/gastroesophageal junction adenocarcinoma: study protocol of a prospective, single-center, single-arm clinical trial

Abstract Background：Gastroesophageal junction (G/GEJ) cancer is a global health burden with poor prognosis, especially for locally advanced or metastatic cases. While perioperative chemotherapy improves outcomes, survival remains limited. Immunotherapy combined with chemotherapy...

Prediction and Progression Stratification of Type II Endoleak After EVAR Using Clinical, Anatomical, and Ultrasound Parameters

OBJECTIVE: To identify factors associated with type II endoleak (T2EL) after endovascular aneurysm repair (EVAR) and to stratify sac progression risk in patients with established T2EL using clinical, anatomic, and ultrasound-derived parameters. METHODS: This ambispective cohort s...

Simultaneous Determination of Total and Unbound Amphotericin B by LC–MS/MS: Application to Protein Binding Analysis

ABSTRACT Amphotericin B (AmB), a first‐line antifungal agent, is highly protein‐bound, and its efficacy and toxicity are primarily determined by the unbound fraction. However, current therapeutic drug monitoring mainly relies on total plasma concentrations, and clinical data on u...

Reduced SRSF1 Expression Correlates with LCK Exon Skipping and Impaired Treg Induction in Immune Thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction and impaired regulatory T-cell (Treg) function, yet its molecular basis remains poorly defined. Here, we show that CD4+ naive T cells from patients with ITP exhibit dim...

LCN2 ‐Driven Fibroblast Ferroptosis‐Associated Injury Promotes Keratinocyte Proliferation via Lipid Peroxidation Signaling in Psoriasis

Psoriasis is a chronic inflammatory skin disorder in which biologics targeting immune pathways have markedly improved clinical outcomes. Nevertheless, persistent oxidative stress and stromal abnormalities in lesional skin indicate that pathogenic mechanisms beyond canonical immun...

Perioperative esketamine and postoperative sleep quality: a systematic review and meta-analysis of randomized trials

Abstract Background Postoperative sleep disturbance (PSD) is common among surgical patients and adversely affects recovery. The benefits of perioperative esketamine on sleep remain incompletely defined. Methods Randomized controlled trials (RCTs) comparing ketamine or esketamine...

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...

Nodular fasciitis of the nasal cavity with USP6 rearrangement: a case report

Nodular fasciitis (NF) is a benign myofibroblastic tumor characterized by rapid growth, self-limiting course, and rearrangement of the USP6 gene. While NF can occur in the head and neck region, cases originating within the nasal cavity are exceedingly rare. We herein report a cas...

MRI Tract‐Based Quantitative Susceptibility Mapping of Limbic White Matter Alterations in Preeclampsia

BACKGROUND: Preeclampsia is associated with long-term cerebrovascular and cognitive risk, but tract-level white matter (WM) involvement remains incompletely characterized. PURPOSE: To investigate whether preeclampsia is associated with tract-level WM susceptibility alterations on...

An interpretable machine learning model integrating 54 test indicators and age: a single-center study on precise discrimination between serous ovarian cancer and ovarian cysts

Abstract Background Serous ovarian cancer (SOC) is a highly malignant subtype of epithelial ovarian tumors, most patients are diagnosed at an advanced stage (III/IV). However, existing single tumor markers have limited diagnostic performance. Therefore, this study aims to develop...

Psychosocial resources, sleep quality, and self-management behavior in patients with type 2 diabetes mellitus: a latent profile and mediation analysis

Background Type 2 diabetes mellitus (T2DM) requires sustained self-management, yet adherence remains suboptimal. This study aimed to identify heterogeneous self-management behavior profiles in T2DM patients and explore the mediating role of sleep quality between integrated psycho...

HE-referenced eosinophil assessment and cutoff estimation using Congo red and Chromotrope 2R staining in chronic rhinosinusitis with nasal polyps

Abstract This cross-sectional histopathological study aimed to compare eosinophil visualization and quantification using Congo red, Chromotrope 2R, and conventional hematoxylin–eosin (HE) staining in chronic rhinosinusitis with nasal polyps (CRSwNP), and to explore HE-referenced...

Exosomes in brain diseases: Mechanisms, advances, and perspectives

The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...