Shandong Provincial Hospital

Laparoscopic−assisted versus purely transanal Soave procedures for Hirschsprung disease in children aged ≤ 4 years: an age−stratified retrospective study

Laparoscopic−assisted and purely transanal Soave procedures are commonly used for Hirschsprung disease, but whether their comparative outcomes differ according to age remains uncertain. This single−center retrospective cohort study included 188 children aged ≤ 48 months who under...

Intestinal microbiota-associated LysoPC(16:0) promotes endometriosis via PPARγ-mediated M2 macrophage polarization and IL-10 secretion

Both gut microbiota dysbiosis and altered pelvic immune microenvironment have been linked to endometriosis (EM), but the metabolites connecting the two remain undefined. Combining 16S rDNA sequencing with non-targeted metabolomics in a murine EM model, we found altered gut microb...

Construction and cross-cohort evaluation of a shared metabolic reprogramming–related gene signature in esophageal and lung squamous cell carcinoma

We investigated directionally consistent metabolic alterations in esophageal squamous cell carcinoma (ESCC) and lung squamous cell carcinoma (LUSC) and developed a pooled prognostic risk score. TCGA and GTEx data were used to identify shared differentially expressed metabolic gen...

FTO-mediated m6A modification of EGR1 mRNA promotes podocyte injury and inflammation via STING1 in diabetic kidney disease

Diabetic kidney disease (DKD) is the predominant cause of end-stage kidney disease, with podocyte injury being a key factor in DKD. Research has shown that RNA demethylase fat-mass and obesity-associated protein (FTO) is related to podocyte injury. In prior research, we modulated...

Direct oral anticoagulants versus vitamin K antagonists in cirrhotic portal vein thrombosis: a systematic review and meta-analysis of clinical, radiological, and safety outcomes

The optimal anticoagulant strategy for portal vein thrombosis (PVT) in patients with cirrhosis remains uncertain. This systematic review and meta-analysis compared the clinical, radiological, and safety outcomes associated with direct oral anticoagulants (DOACs) versus vitamin K...

Macrophage-derived MMP14 fosters immunosuppressive tumor microenvironment by regulating soluble semaphorin 4D

Abstract High expression of semaphorin 4D (SEMA4D) in tumor cells fosters an immunosuppressive tumor microenvironment (TME), yet the underlying tumor-macrophage crosstalk remains poorly understood. Here, we investigated this regulatory axis using in vitro co-cultures and SEMA4D g...

Systemic inflammation response index

This study aims to explore the association between the systemic inflammation response index (SIRI) and the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) by retrospectively analyzing clinical data derived from the Medical Informati...

Prognostic value of baseline serum lactate dehydrogenase in EGFR-mutant lung adenocarcinoma treated with first-line EGFR-TKI monotherapy

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are standard first-line treatment for patients with sensitizing EGFR-mutant lung adenocarcinoma; however, treatment outcomes remain heterogeneous and acquired resistance eventually develops in most patients...

Oral and oropharyngeal bacterial microbiota in children with obstructive mouth breathing: a pilot cross-sectional study

Obstructive mouth breathing (OMB) is a common pediatric condition associated with oral and systemic health problems. OMB may alter the oral and oropharyngeal environment through mucosal dryness, reduced salivary clearance, altered airflow and gas exchange, and impaired local muco...

Multiple organ failure following severe heat stroke complicated by AMSAN-type Guillain-Barré syndrome: a case report and literature review

Heat stroke is a severe form of heat-related injury that can provoke a systemic inflammatory response and cytokine storm, disrupting immune homeostasis. Guillain–Barré syndrome (GBS) has rarely been reported during recovery from heat stroke, and the nature of this association rem...

Optimized tubeless strategy: combined pre-stenting and omission of postoperative ureteral stent reduces systemic inflammation and complications after flexible ureteroscopy for middle-upper calyceal stones

To evaluate the clinical and inflammatory outcomes of an optimized “pre-stented tubeless” strategy (preoperative stent placement followed by stent omission after surgery) compared to conventional stenting approaches in patients undergoing flexible ureteroscopy (FURS) for middle-u...

Self-perceived hearing impairment, hearing aid use, and willingness to use hearing aids among older adults in rural China

Despite the substantial health burden posed by hearing impairment (HI) in older adults and although hearing aids are effective interventions, population-level data on hearing aid use remain scarce, and the determinants of willingness to use hearing aids have not been comprehensiv...

Association Between Air Pollution and Psoriasis-Related Outcomes: A Systematic Review and Meta-analysis

Skin diseases are a group of consequences due to exposure to air pollution that have received less attention. Among these diseases, the relationships between short-term and long-term exposure to air pollutants and psoriasis remain uncertain. The present systematic review and meta...

NINJ2 alleviates inflammatory bowel disease by regulating the macrophage ZBP1-PANoptosis pathway

Abstract Inflammatory bowel disease (IBD) is a chronic, relapsing intestinal disorder with a complex etiology and incompletely understood pathogenesis, posing significant challenges for clinical management. The NINJ2 gene is located on chromosome 12, a region enriched with IBD su...

Multimorbidity patterns and domain-specific intrinsic capacity impairments among rural older adults: a multiple correspondence analysis and k-means clustering study

Abstract Background Multimorbidity is prevalent among older adults, but its specific patterns and differential associations with impairments across intrinsic capacity (IC) domains remain under-explored. This study aimed to identify stable multimorbidity patterns in rural older ad...

EXPRESS: Diagnostic Accuracy of Noninvasive Translesional Pressure Ratio Based on Magnetic Resonance Imaging for Intracranial Atherosclerotic Stenosis: A Validation Study

The anatomic stenosis severity of intracranial atherosclerotic stenosis (ICAS) does not reliably reflect lesion-specific hemodynamic impairment, and invasive pressure-wire assessment is technically challenging in the cerebral circulation. This study aimed to develop and validate...

Roles of lactate and protein lactylation in neurogenesis and neurodegenerative disease

Neurodegenerative diseases are characterized by the gradual deterioration and impaired functionality of neuronal cells, which in turn results in the progressive decline of both cognitive capabilities and motor performance. Over the past few years, accumulating evidence has demons...

Single-suture parachute technique for hepaticojejunostomy in laparoscopic pancreatoduodenectomy: a multicenter, large-scale study

The optimal technique for hepaticojejunostomy (HJ) during laparoscopic pancreatoduodenectomy (LPD) remains debated. This multicenter, single‑arm study aimed to evaluate the safety, feasibility, and reproducibility of the single‑suture parachute technique for HJ (SSPT‑HJ) in LPD....

Development of an explainable machine learning model for predicting six-month consciousness recovery in patients with prolonged disorders of consciousness

With advances in emergency care systems, the number of patients with prolonged disorders of consciousness (pDoC) has markedly increased. To optimize the allocation of healthcare resources and mitigate risks, the early and accurate identification of recovery potential in pDoC is e...

Unilateral biportal endoscopic lumbar fusion versus minimally invasive transforaminal lumbar interbody fusion for single-level mild to moderate lumbar spondylolisthesis: a retrospective study

To compare the early clinical outcomes and radiographic outcomes of unilateral biportal endoscopic transforaminal lumbar interbody fusion (ULIF) versus minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of single-level mild to moderate lumbar sp...