Shandong Provincial Hospital

Early-life recurrent antibiotic use and risks of adult kidney cancer and sex-specific cancers: a prospective cohort study in the UK Biobank

There is little evidence about the associations of long-term or recurrent antibiotics use (LRAU) during early life with cancer risk. Our study aimed to assess the associations via Cox proportional hazards regression, using data from the UK Biobank (UKB). The main outcomes were th...

Low-dose interval radiotherapy combined with tirelizumab and SOX chemotherapy neoadjuvant therapy for locally advanced gastric/gastroesophageal junction adenocarcinoma: study protocol of a prospective, single-center, single-arm clinical trial

Abstract Background：Gastroesophageal junction (G/GEJ) cancer is a global health burden with poor prognosis, especially for locally advanced or metastatic cases. While perioperative chemotherapy improves outcomes, survival remains limited. Immunotherapy combined with chemotherapy...

Prediction and Progression Stratification of Type II Endoleak After EVAR Using Clinical, Anatomical, and Ultrasound Parameters

OBJECTIVE: To identify factors associated with type II endoleak (T2EL) after endovascular aneurysm repair (EVAR) and to stratify sac progression risk in patients with established T2EL using clinical, anatomic, and ultrasound-derived parameters. METHODS: This ambispective cohort s...

Reduced SRSF1 Expression Correlates with LCK Exon Skipping and Impaired Treg Induction in Immune Thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction and impaired regulatory T-cell (Treg) function, yet its molecular basis remains poorly defined. Here, we show that CD4+ naive T cells from patients with ITP exhibit dim...

Simultaneous Determination of Total and Unbound Amphotericin B by LC–MS/MS: Application to Protein Binding Analysis

ABSTRACT Amphotericin B (AmB), a first‐line antifungal agent, is highly protein‐bound, and its efficacy and toxicity are primarily determined by the unbound fraction. However, current therapeutic drug monitoring mainly relies on total plasma concentrations, and clinical data on u...

LCN2 ‐Driven Fibroblast Ferroptosis‐Associated Injury Promotes Keratinocyte Proliferation via Lipid Peroxidation Signaling in Psoriasis

Psoriasis is a chronic inflammatory skin disorder in which biologics targeting immune pathways have markedly improved clinical outcomes. Nevertheless, persistent oxidative stress and stromal abnormalities in lesional skin indicate that pathogenic mechanisms beyond canonical immun...

Perioperative esketamine and postoperative sleep quality: a systematic review and meta-analysis of randomized trials

Abstract Background Postoperative sleep disturbance (PSD) is common among surgical patients and adversely affects recovery. The benefits of perioperative esketamine on sleep remain incompletely defined. Methods Randomized controlled trials (RCTs) comparing ketamine or esketamine...

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...

Nodular fasciitis of the nasal cavity with USP6 rearrangement: a case report

Nodular fasciitis (NF) is a benign myofibroblastic tumor characterized by rapid growth, self-limiting course, and rearrangement of the USP6 gene. While NF can occur in the head and neck region, cases originating within the nasal cavity are exceedingly rare. We herein report a cas...

MRI Tract‐Based Quantitative Susceptibility Mapping of Limbic White Matter Alterations in Preeclampsia

BACKGROUND: Preeclampsia is associated with long-term cerebrovascular and cognitive risk, but tract-level white matter (WM) involvement remains incompletely characterized. PURPOSE: To investigate whether preeclampsia is associated with tract-level WM susceptibility alterations on...

An interpretable machine learning model integrating 54 test indicators and age: a single-center study on precise discrimination between serous ovarian cancer and ovarian cysts

Abstract Background Serous ovarian cancer (SOC) is a highly malignant subtype of epithelial ovarian tumors, most patients are diagnosed at an advanced stage (III/IV). However, existing single tumor markers have limited diagnostic performance. Therefore, this study aims to develop...

Psychosocial resources, sleep quality, and self-management behavior in patients with type 2 diabetes mellitus: a latent profile and mediation analysis

Background Type 2 diabetes mellitus (T2DM) requires sustained self-management, yet adherence remains suboptimal. This study aimed to identify heterogeneous self-management behavior profiles in T2DM patients and explore the mediating role of sleep quality between integrated psycho...

HE-referenced eosinophil assessment and cutoff estimation using Congo red and Chromotrope 2R staining in chronic rhinosinusitis with nasal polyps

Abstract This cross-sectional histopathological study aimed to compare eosinophil visualization and quantification using Congo red, Chromotrope 2R, and conventional hematoxylin–eosin (HE) staining in chronic rhinosinusitis with nasal polyps (CRSwNP), and to explore HE-referenced...

Exosomes in brain diseases: Mechanisms, advances, and perspectives

The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...

ID4 enhances ferroptosis sensitivity in gastric cancer by promoting ubiquitination degradation of GPX4

Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide, presenting a serious threat to human health due to its high fatality rates and incidence. Ferroptosis, as a novel form of programmed cell death, demonstrates significant potential in cancer therapy. The...

Familial tailgut cysts in two sisters presenting with sacral dimple sign: a case report

Tailgut cysts are rare congenital cystic lesions arising from remnants of the embryological postanal primitive gut. Familial clustering of tailgut cysts has been rarely reported, and the association with sacral dimple sign as an early diagnostic indicator remains underexplored. W...

Targeting intratumor microbiota in oral squamous cell carcinoma from potential mechanisms to future opportunities

Abstract Oral squamous cell carcinoma (OSCC) is the predominant subtype of oral cancer, accounting for over 90% of all cases, with high incidence and poor long-term survival. Advances in the etiology of OSCC and ongoing characterization of the microbiota have revealed a strong as...

6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes

levels, downregulation of GPX4, and accumulation of lipid peroxidation. A genome-wide CRISPR/Cas9 knockout screen identified EXOC7 as a critical mediator of 6PPD-Q-induced podocyte injury. Mechanistically, 6PPD-Q disrupted the E3 ubiquitin ligase activity of MARCHF2, leading to r...

OMVs of Pseudomonas aeruginosa extracted from chronic suppurative otitis media trigger ototoxicity: possible relation to activation of NLRP3 inflammasome

Abstract Background Chronic suppurative otitis media (CSOM) can lead to sensorineural hearing loss (SNHL), but the underlying mechanisms remain incompletely understood. This study aimed to investigate whether the outer membrane vesicles (OMVs) from Pseudomonas aeruginosa ( P.aeru...