Shandong First Medical University

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Targeting p38α promotes Parkin-mediated mitophagy to attenuate severe acute pancreatitis via suppressing the mtDNA/cGAS-STING signaling pathway

Abstract Severe acute pancreatitis (SAP) is a life-threatening acute inflammatory disorder characterized by systemic inflammation and high mortality, for which specific targeted therapeutic strategies are still severely lacking in clinical practice. Mitochondrial dysfunction and...

A multiomics-clinical model to predict treatment response in psoriasis

Psoriasis is a chronic inflammatory skin disease with highly variable responses to biologic therapies. Predictive tools to guide personalized treatment remain an unmet clinical need. To develop and validate a multiomics-clinical model for predicting a 75% reduction in the Psorias...

Research Progressin the Prevention and Treatment of Breast Cancer With Phytoestrogens from Chinese Medicinal Plants.

Phytoestrogens are a class of natural compounds existing in plants，with their chemical structures similar to that of the endogenous estrogen 17β-estradiol in mammals.They can exert estrogenic or anti-estrogenic biological effects by binding to estrogen receptors，and have a wide...

Inflammation as a central mechanism: interactions among epithelial, immune, and neural units in dry eye disease and their therapeutic implications

Abstract Dry eye disease (DED) is a prevalent multifactorial ocular surface disorder. Early research primarily attributed its pathogenesis to insufficient tear secretion or excessive tear evaporation. Advances in mechanistic research have shifted the academic understanding from a...

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

ABSTRACT Induction of pyroptosis is a novel strategy for multiple myeloma (MM) treatment, but the underlying mechanism remains elusive. In the analysis of the transcriptomic profile in pyroptotic MM cells, we find the interferon‐alpha inducible protein IFI27 is strikingly upregul...

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Triple-negative breast cancer (TNBC) is characterized by high metastatic tendency and poor prognosis, largely driven by dynamic crosstalk between cancer cells and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are a major component of the TME, yet their fu...

Predictors and prognostic stratification of bronchiolitis obliterans syndrome after pediatric allogeneic hematopoietic stem cell transplantation

Abstract Background Bronchiolitis Obliterans Syndrome (BOS) following pediatric allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with high morbidity and mortality, largely due to diagnostic delays and static prognostic assessments. This study aimed to...

Development of a patient journey map for diabetic retinopathy: exploring evidence from qualitative research

The World Health Organization has emphasized people-centered health, shifting focus from disease to patient needs. Patient Journey Mapping has emerged as a valuable methodological approach to support healthcare and nursing management by visualizing patient experiences and identif...

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

To date, the treatment of acute myeloid leukaemia (AML) remains a major challenge in hematologic malignancies, particularly among elderly patients who are unfit for intensive chemotherapy. Venetoclax, a BCL-2 inhibitor, in combination with azacitidine, has significantly improved...

Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care

Abstract Chronic pelvic pain syndrome (CPPS) encompasses a heterogeneous group of debilitating conditions including interstitial cystitis/bladder pain syndrome (IC/BPS), chronic abacterial prostatitis, endometriosis, and pelvic congestion syndrome, among others. Despite advances...

A Piezoelectric Microtool for In Vitro Elastic Modulus Measurement and Hepatocellular Carcinoma Boundary Identification

Accurate identification of tumor boundaries is crucial for effective local treatment and protection of surrounding healthy tissue. However, current methods for rapidly characterizing local tissue biomechanical properties remain limited. In this study, we present a novel MEMS-inte...

Health utility and equity-related correlates among adults with rare diseases in Foshan City, China: an exploratory cross-sectional study using the EQ-5D-5L

Rare diseases (RDs) are associated with substantial and potentially avoidable health inequities related to chronic disability, social disadvantage, and high non-medical costs. Evidence on health-related quality of life (HRQoL) among adults living with RDs in China remains scarce,...

NAT10-mediated ac4C modification and CEBPB-mediated transcriptional activation converge on CBS to promote malignant progression in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignant tumor, and its development mechanism remains unclear. Ferroptosis, as a novel regulatory mode of cell death, plays an important role in tumor regulation. However, the function of cystathionine-β-synthase (...

Prospective evaluation of high-risk assessment strategy for esophageal cancer: a community-based cancer screening cohort in rural China

Abstract Objective To evaluate a questionnaire-based strategy for risk stratification in population-based esophageal cancer(EC) screening in China. Methods 120,488 residents from four cancer screening centers in Shandong Province were enrolled in a prospective cohort between 2013...

Breviscapine Blunts Hypertrophic Scar Formation via Dual Suppression of TGF-β1 Signaling and the Akt-mTOR Pathway

Background: Hypertrophic scar (HS) arises from aberrant cutaneous wound healing, characterized by uncontrolled myofibroblast proliferation and disproportionate extracellular matrix (ECM) accumulation. Breviscapine, a natural compound, suppresses inflammation and fibrosis. This st...

ZCCHC4 promotes replication-dependent histone mRNA translation through interaction with the eIF3 complex

Abstract Histone synthesis is tightly coupled with DNA replication to ensure proper chromatin assembly and genome stability. To meet the sharply elevated demand for histones during S phase, eukaryotic cells employ specialized mechanisms to translate replication-dependent (RD) his...

The cholesterol, high-density lipoprotein, and glucose index and its derived indices predict cardiometabolic multimorbidity development and progression in metabolic dysfunction-associated steatotic liver disease individuals: a prospective cohort study

Dysregulation of cholesterol, high-density lipoprotein cholesterol, and glucose metabolism is thought to be an important metabolic link between metabolic dysfunction-associated steatotic liver disease (MASLD), type 2 diabetes (T2D), and cardiovascular disease. Although the choles...

Molecular and clinical characterization of human adenovirus in hospitalized pediatric respiratory infections: a five-year study

Abstract Background Human adenovirus (HAdV) is a major pathogen of responsible for respiratory tract infections (RTIs) in children in China. This study analyzed clinical data from hospitalized pediatric HAdV infections over a five-year period to characterize the epidemiology, cli...