Shandong First Medical University

Oral and oropharyngeal bacterial microbiota in children with obstructive mouth breathing: a pilot cross-sectional study

Obstructive mouth breathing (OMB) is a common pediatric condition associated with oral and systemic health problems. OMB may alter the oral and oropharyngeal environment through mucosal dryness, reduced salivary clearance, altered airflow and gas exchange, and impaired local muco...

Recent advances in Ganoderma lucidum-derived bioactive components for cancer therapy

Abstract Ganoderma lucidum has attracted increasing attention in cancer research because of its diverse bioactive components and immunomodulatory properties. However, its antitumor effects are often discussed as broad “anticancer activity”, which may obscure the distinct roles of...

APOF regulates the malignancy and inflammatory response of hepatocellular carcinoma cells through PPAR signaling pathway

Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence. It is often diagnosed at an advanced stage, with intrahepatic or extrahepatic metastasis, and cannot be cured by radical surgery. In human HCC cell lines, Apolipoprotein F (APOF) gene promoter activity was s...

Ubiquitin-specific protease 7 is associated with vascular calcification in chronic kidney disease by regulating RUNX2 stabilization

Background There is a severe problem of vascular calcification (VC) in chronic kidney disease (CKD). The purpose of this study was to explore the function and underlying mechanisms of ubiquitin-specific protease 7 (USP7) in VC-associated CKD. Methods Plasma USP7 was measured in 2...

Ultrasound-activatable bacteria for biomedical applications

Bacteria have emerged as powerful therapeutic vectors owing to their intrinsic tumour tropism, genetic programmability, and living therapeutic functions. However, the trade-off between their autonomous proliferation and potential immunotoxicity restricts their clinical translatio...

Mitochondrial fitness for sustainable male health – a 3PM-guided healthcare innovation

Abstract Male health is much more than only an essential pillar of the sustainable socio-demographic development of each society. To this end, erectile dysfunction, preventable male infertility, and urological cancers (including testicular, bladder, kidney, prostate, and penile o...

Comparison of quantitative CT parameters acquired via the CT spine bone quantification system between L1 cortical and cancellous bone for predicting severity in male patients with chronic obstructive pulmonary disease: a retrospective study

Until present, data on the association between cortical bone changes in osteoporosis and severity of the condition of Chronic obstructive pulmonary disease (COPD) patients are lacking. This study aims to explore and compare the value of quantitative parameters of cortical and can...

Metal-phenolic conducting polymer hydrogels for multifunctional cardiac patches and post-infarction myocardial repair

Myocardial infarction (MI) causes irreversible cardiomyocyte loss and adverse ventricular remodeling, yet current cardiac patches remain limited by inadequate bioactivity and poor electrical integration with host myocardium. We report a multifunctional metal–phenolic conducting p...

Multiple organ failure following severe heat stroke complicated by AMSAN-type Guillain-Barré syndrome: a case report and literature review

Heat stroke is a severe form of heat-related injury that can provoke a systemic inflammatory response and cytokine storm, disrupting immune homeostasis. Guillain–Barré syndrome (GBS) has rarely been reported during recovery from heat stroke, and the nature of this association rem...

Spatial genetic structure and distribution of knockdown resistance (kdr) mutations in Aedes albopictus across different climatic zones of China

Aedes albopictus is a globally invasive mosquito and a major vector of dengue and other arboviruses in China, where effective control is increasingly constrained by environmental change and insecticide resistance. Climate zones and rising regional connectivity may reshape populat...

Combined Small Treatment Zone Orthokeratology and Alternate-Day 0.01% Atropine for Axial Elongation Control in Rapidly Progressing Myopic Children

Purpose: To evaluate the efficacy of small treatment zone (STZ) orthokeratology (ortho-K) combined with alternate-day 0.01% atropine to control axial elongation in rapidly progressing myopic children and identify associated optical predictors. Methods: This prospective randomized...

Integrating neuroimaging, transcriptomics and single-cell sequencing identifies candidate molecular features of cortical vulnerability in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that leads to reductions in cortical surface area (SA) and thickness (TH). However, the genetic and molecular mechanisms underlying these cortical structural alterations remain unclear. This st...

Three case reports and a literature review of HER-2-overexpressing mammary Paget’s disease combined with invasive breast cancer

To investigate the clinicopathological characteristics, treatment, and short-term outcomes of human epidermal growth factor receptor 2 (HER-2)-overexpressing mammary Paget’s disease (MPD) combined with invasive ductal carcinoma (IDC), with an emphasis on the high proportion of HE...

Optimized tubeless strategy: combined pre-stenting and omission of postoperative ureteral stent reduces systemic inflammation and complications after flexible ureteroscopy for middle-upper calyceal stones

To evaluate the clinical and inflammatory outcomes of an optimized “pre-stented tubeless” strategy (preoperative stent placement followed by stent omission after surgery) compared to conventional stenting approaches in patients undergoing flexible ureteroscopy (FURS) for middle-u...

Preclinical and First‐In‐Human Evaluation of Ribupatide ( HRS9531 ), a Dual GLP ‐1/ GIP Receptor Agonist

ABSTRACT Aims This study assessed the preclinical and clinical pharmacokinetics (PK), pharmacodynamics (PD), safety and tolerability of ribupatide (HRS9531), a novel dual agonist of glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptors....

NINJ2 alleviates inflammatory bowel disease by regulating the macrophage ZBP1-PANoptosis pathway

Abstract Inflammatory bowel disease (IBD) is a chronic, relapsing intestinal disorder with a complex etiology and incompletely understood pathogenesis, posing significant challenges for clinical management. The NINJ2 gene is located on chromosome 12, a region enriched with IBD su...

Association Between Air Pollution and Psoriasis-Related Outcomes: A Systematic Review and Meta-analysis

Skin diseases are a group of consequences due to exposure to air pollution that have received less attention. Among these diseases, the relationships between short-term and long-term exposure to air pollutants and psoriasis remain uncertain. The present systematic review and meta...

Biotin‐Engineered Phenothiazine Photosensitizer Boosts Type I Photodynamic Therapy via Singlet‐Excited‐State Electron Transfer

Comprehensive Summary Type II‐dominant photosensitizers often suffer from reduced photodynamic efficacy under tumor hypoxia. We report a biotin‐modified phenothiazine photosensitizer termed DHU‐Blue‐7, which converts type II methylene blue (MB)‐like photosensitization into a type...

Squamous cell carcinoma arising from ovarian mature cystic teratoma with concurrent cervical high-risk HPV infection and low-grade squamous intraepithelial lesion: a case report

Malignant transformation of ovarian mature cystic teratoma (MCT) is uncommon, with squamous cell carcinoma (SCC) being the predominant type. Its pathogenesis remains poorly understood, and the potential role of human papillomavirus (HPV) infection is controversial. A 58-year-old...

Multimorbidity patterns and domain-specific intrinsic capacity impairments among rural older adults: a multiple correspondence analysis and k-means clustering study

Abstract Background Multimorbidity is prevalent among older adults, but its specific patterns and differential associations with impairments across intrinsic capacity (IC) domains remain under-explored. This study aimed to identify stable multimorbidity patterns in rural older ad...