Shandong First Medical University

NonlinearSynergistic Coupling of Poisson Deformationand Crack Engineering Enables Linear Mechanosensing up to 4 MPa

Abstract Reliable and accurate physiological mechanosensing requires tactile sensors that maintain linearity across ultrawide ranges, yet most reported devices saturate below 500 kPa due to strain hardening and deformation saturation of elastic microstructures. Balancing this lon...

Loss of LATS1 promotes immune evasion in colon cancer via YAP/TEAD-driven lactate metabolism reprogramming

Abstract The Hippo pathway components YAP and TAZ have been implicated in tumor immunity, but the role of upstream kinase LATS1 in colon cancer immune evasion remains unclear. This study aimed to investigate the function of LATS1 in regulating the tumor immune microenvironment (T...

Psychosocial resources, sleep quality, and self-management behavior in patients with type 2 diabetes mellitus: a latent profile and mediation analysis

Background Type 2 diabetes mellitus (T2DM) requires sustained self-management, yet adherence remains suboptimal. This study aimed to identify heterogeneous self-management behavior profiles in T2DM patients and explore the mediating role of sleep quality between integrated psycho...

Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives

Lung cancer remains a leading cause of cancer-related deaths worldwide. Despite advances in targeted therapy and immunotherapy, treatment outcomes are often constrained by tumor heterogeneity and the complex tumor microenvironment. Recent studies highlight the critical role of th...

An interpretable machine learning model integrating 54 test indicators and age: a single-center study on precise discrimination between serous ovarian cancer and ovarian cysts

Abstract Background Serous ovarian cancer (SOC) is a highly malignant subtype of epithelial ovarian tumors, most patients are diagnosed at an advanced stage (III/IV). However, existing single tumor markers have limited diagnostic performance. Therefore, this study aims to develop...

The Matricellular Protein CCN1 Induces Corneal Stromal Cells Senescence and Inflammation to Trigger Extracellular Matrix Remodeling in Keratoconus

Purpose: Keratoconus (KC) is a multifactorial corneal degenerative disorder characterized by reduced extracellular matrix (ECM) and cellular content. This study investigates the role and mechanism of cellular communication network factor 1 (CCN1) in KC progression. Methods: The e...

A retrospective study on clinical and survival differences of head and neck versus other second primary malignancies in nasopharyngeal carcinoma survivors

Abstract Background Nasopharyngeal carcinoma (NPC) survivors face elevated risks of second primary malignancies (SPM); however, disparities between head and neck (HN-SPM) and non-head and neck (non-HN-SPM) are incompletely characterized. Methods This retrospective study analyzed...

Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity

Neutrophils are increasingly recognized as key orchestrators of the immunosuppressive tumor microenvironment, yet their intrinsic plasticity, short lifespan and resistance to genetic manipulation have impeded therapeutic targeting. Here, we report a non-pharmacological, biophysic...

Exosomes in brain diseases: Mechanisms, advances, and perspectives

The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...

Targeting FibroblastActivation Protein for PrecisionMedicine

Conspectus The advancement of precision medicine depends critically on well-defined molecular targets. Pathologically activated fibroblasts drive disease progression in cancer, fibrosis and chronic inflammation through sustained inflammation, extracellular matrix remodeling and p...

Factors affecting job choices among primary health workers in China: a discrete choice experiment study

Primary health workers (PHWs) are crucial for primary health care, yet shortages and maldistribution persist in China. The study aimed to quantify their job preferences and the importance of key job attributes to inform attraction and retention policies. A discrete choice experim...

ID4 enhances ferroptosis sensitivity in gastric cancer by promoting ubiquitination degradation of GPX4

Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide, presenting a serious threat to human health due to its high fatality rates and incidence. Ferroptosis, as a novel form of programmed cell death, demonstrates significant potential in cancer therapy. The...

Development and validation of a preoperative interpretable machine learning model for predicting myocardial injury following lung cancer surgery

Myocardial injury after non-cardiac surgery (MINS) is a common complication following lung cancer surgery and is associated with adverse prognostic outcomes. Preoperative cardiac risk assessment is essential for optimizing perioperative management and improving patient outcomes....

Different vault outcomes following implantable collamer lens implantation in eyes with ciliary body cysts: a case report

Ciliary body cysts are common incidental findings during preoperative screening for implantable collamer lens (ICL) implantation. Although their presence is generally not considered a contraindication to surgery, cysts extending into the ciliary sulcus may influence haptic seatin...

Familial tailgut cysts in two sisters presenting with sacral dimple sign: a case report

Tailgut cysts are rare congenital cystic lesions arising from remnants of the embryological postanal primitive gut. Familial clustering of tailgut cysts has been rarely reported, and the association with sacral dimple sign as an early diagnostic indicator remains underexplored. W...

Targeting intratumor microbiota in oral squamous cell carcinoma from potential mechanisms to future opportunities

Abstract Oral squamous cell carcinoma (OSCC) is the predominant subtype of oral cancer, accounting for over 90% of all cases, with high incidence and poor long-term survival. Advances in the etiology of OSCC and ongoing characterization of the microbiota have revealed a strong as...

6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes

levels, downregulation of GPX4, and accumulation of lipid peroxidation. A genome-wide CRISPR/Cas9 knockout screen identified EXOC7 as a critical mediator of 6PPD-Q-induced podocyte injury. Mechanistically, 6PPD-Q disrupted the E3 ubiquitin ligase activity of MARCHF2, leading to r...

OMVs of Pseudomonas aeruginosa extracted from chronic suppurative otitis media trigger ototoxicity: possible relation to activation of NLRP3 inflammasome

Abstract Background Chronic suppurative otitis media (CSOM) can lead to sensorineural hearing loss (SNHL), but the underlying mechanisms remain incompletely understood. This study aimed to investigate whether the outer membrane vesicles (OMVs) from Pseudomonas aeruginosa ( P.aeru...