Shandong First Medical University

A segmentation-guided CNN–Vision transformer feature fusion framework for multi-class breast ultrasound image classification

Breast ultrasound (BU) imaging is widely used for detecting breast abnormalities because it is cost-effective, non-invasive, and suitable for dense breast tissue. However, multi-class classification of BU images is considered a challenging task due to low contrast, speckle noise,...

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes...

Self-Powered Cs2AgBiBr6 Photon-Counting Detectors with Low Dark Count Rate at Room Temperature

Abstract Photon-counting detectors (PCDs) are highly anticipated for their exceptional ability to resolve weak optical signals that exist against a relatively low-background-noise environment, especially in medical computerized tomography. The performance of conventional silicon-...

Metabolic and vascular stress drive progression of erectile dysfunction in a rat model

Erectile dysfunction (ED) is a common male sexual disorder, with the vasculogenic subtype primarily driven by endothelial injury and metabolic dysfunction. Current research often lacks a systematic, time-course analysis of its progressive pathology. We performed a 16-week time-co...

EXPRESS: Diagnostic Accuracy of Noninvasive Translesional Pressure Ratio Based on Magnetic Resonance Imaging for Intracranial Atherosclerotic Stenosis: A Validation Study

The anatomic stenosis severity of intracranial atherosclerotic stenosis (ICAS) does not reliably reflect lesion-specific hemodynamic impairment, and invasive pressure-wire assessment is technically challenging in the cerebral circulation. This study aimed to develop and validate...

Biohybrid M13 phage backpacks for active blood–brain barrier traversal and precision central nervous system leukemia treatment

Abstract Central nervous system (CNS) leukemia remains a major clinical challenge in acute lymphoblastic leukemia, largely due to the restrictive nature of the blood–brain barrier (BBB), which severely limits therapeutic delivery and contributes to high relapse rates and poor pro...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Systematic Analysis of Stromal-Epithelial Crosstalk Reveals the FGF21-FGFR3 Axis as a Key Driver of Corneal Wound Healing

Purpose: Corneal epithelial defects are a significant clinical problem and pose a severe threat to vision. However, their underlying mechanisms remain largely elusive. Here, we used single-cell RNA sequencing (scRNA-seq) and constructed cell-cell communication networks between co...

EPHX2 Loss Promotes CRC Migration via EET ‐Dependent Chemokine Elevation and Mitochondrial Defect

ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and carcinogenesis. However, the role and mechanism of EPHX2 in colorectal cancer (CRC) migrati...

Intranasal delivery of BDNF-enriched small extracellular vesicles ameliorates cognitive impairment and Alzheimer’s disease-like pathology in APP/PS1 mice

Alzheimer’s disease (AD), the leading cause of dementia, still lacks broadly effective disease-modifying therapies. Here, we engineered brain-derived neurotrophic factor (BDNF)-enriched small extracellular vesicles (BDNF-sEVs) from human induced pluripotent stem cell-derived mese...

Enhancing prediction of pathological complete response to neoadjuvant immunotherapy in non-small cell lung cancer by whole-lung radiomics

To evaluate the utility of whole-lung radiomics for predicting pathological complete response (pCR) to neoadjuvant immunotherapy in patients with non-small cell lung cancer (NSCLC), and further explore whether integrating whole-lung radiomics with tumor-specific radiomics could e...

Suturing strategies for annular defects following lumbar discectomy: a structured narrative review and a hypothesis-generating functional assessment framework

Residual annular defects after lumbar discectomy may contribute to recurrent disc herniation, and several repair strategies—including direct annulus-to-annulus suturing, bone-anchored repair, and soft-tissue augmentation—have been described. However, evidence directly comparing s...

Development of a multiplex real-time PCR assay with fluorescence probe-melting-curve analysis for one-tube detection of respiratory pathogens

Pathogens causing respiratory infections have reemerged globally since the COVID-19 pandemic. Rapid and accurate identification of respiratory pathogens is critical for diagnosis and treatment. In this study, we developed and evaluated a multiplex real-time PCR assay with a fluor...

Roles of lactate and protein lactylation in neurogenesis and neurodegenerative disease

Neurodegenerative diseases are characterized by the gradual deterioration and impaired functionality of neuronal cells, which in turn results in the progressive decline of both cognitive capabilities and motor performance. Over the past few years, accumulating evidence has demons...

Increased receptor binding and spike glycosylation, remodeled immune escape of surging SARS-CoV-2 subvariant BA.3.2.2/RE.2.2/Cicada

SARS-CoV-2 continues to evolve. The subvariant BA.3.2 (Cicada), a derivative of the Omicron BA.3 subtype first detected in late 2024, harbors multiple spike protein mutations, ORF7 and ORF8 deletions, and has recently evolved sublineages (BA.3.2.1 and BA.3.2.2), rendering it a cr...

Systematic Evaluation of Graph Neural Networks for Ligand-Based Virtual Screening on ChEMBL Datasets

Abstract The performance of target-specific, ligand-based virtual screening models is strongly influenced by dataset characteristics, including data availability, class imbalance, and evaluation strategies. In this work, we perform a systematic evaluation of graph neural networks...

Single-suture parachute technique for hepaticojejunostomy in laparoscopic pancreatoduodenectomy: a multicenter, large-scale study

The optimal technique for hepaticojejunostomy (HJ) during laparoscopic pancreatoduodenectomy (LPD) remains debated. This multicenter, single‑arm study aimed to evaluate the safety, feasibility, and reproducibility of the single‑suture parachute technique for HJ (SSPT‑HJ) in LPD....

Development of an explainable machine learning model for predicting six-month consciousness recovery in patients with prolonged disorders of consciousness

With advances in emergency care systems, the number of patients with prolonged disorders of consciousness (pDoC) has markedly increased. To optimize the allocation of healthcare resources and mitigate risks, the early and accurate identification of recovery potential in pDoC is e...

Unilateral biportal endoscopic lumbar fusion versus minimally invasive transforaminal lumbar interbody fusion for single-level mild to moderate lumbar spondylolisthesis: a retrospective study

To compare the early clinical outcomes and radiographic outcomes of unilateral biportal endoscopic transforaminal lumbar interbody fusion (ULIF) versus minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of single-level mild to moderate lumbar sp...

Joint associations of non-intact family types and health-risk behaviors with mental health outcomes: evidence from a large-scale survey among adolescents in Shandong Province, China

Rising global divorce rates have increased the prevalence of non-intact families, which may be associated with adolescents’ behaviors and mental health. Non-intact family types (NIFTs) and health-risk behaviors (HRBs) are both associated with adolescent mental health, yet previou...