Shandong First Medical University

Mitochondria-Targeting Bismuth Selenide Nanoparticles for X-ray CT Imaging and Cancer Radiotherapy

Abstract Radiotherapy plays an indispensable role in clinical cancer treatment. Designing dual-modal agents for computed tomography (CT) imaging and radiotherapy sensitization remains a great challenge in tumor therapy. In this study, we designed and synthesized bismuth-based nan...

3D DNA Framework-Encoded Multicolor DNA Amplifiers Permit Dual-Modal Simultaneous Imaging of Intracellular Multiplexed mRNAs

Abstract High-sensitivity, simultaneous visualization of multiple low-abundance intracellular mRNAs is appealed to elucidating their synergistic functions and guiding cancer diagnosis and treatment. Engineered nanoprobes integrating anti-enzymatic degradation, efficient signal am...

Laparoscopic−assisted versus purely transanal Soave procedures for Hirschsprung disease in children aged ≤ 4 years: an age−stratified retrospective study

Laparoscopic−assisted and purely transanal Soave procedures are commonly used for Hirschsprung disease, but whether their comparative outcomes differ according to age remains uncertain. This single−center retrospective cohort study included 188 children aged ≤ 48 months who under...

Intestinal microbiota-associated LysoPC(16:0) promotes endometriosis via PPARγ-mediated M2 macrophage polarization and IL-10 secretion

Both gut microbiota dysbiosis and altered pelvic immune microenvironment have been linked to endometriosis (EM), but the metabolites connecting the two remain undefined. Combining 16S rDNA sequencing with non-targeted metabolomics in a murine EM model, we found altered gut microb...

Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with a high unmet need, particularly for treatment-resistant tunnels. Integrated multiomics analysis revealed that HS tunnels are spatially organized, self-amplifying inflammatory circuits driven by synergistic...

Construction and cross-cohort evaluation of a shared metabolic reprogramming–related gene signature in esophageal and lung squamous cell carcinoma

We investigated directionally consistent metabolic alterations in esophageal squamous cell carcinoma (ESCC) and lung squamous cell carcinoma (LUSC) and developed a pooled prognostic risk score. TCGA and GTEx data were used to identify shared differentially expressed metabolic gen...

AGDE-Net: a lightweight attention-guided dual-encoder network for tumor core and peritumoral edema segmentation in adult glioma

Abstract Background Glioma is a malignant primary brain tumor arising from glial cells, often resulting in fatal outcomes without timely treatment. Accurate and reliable tumor segmentation is essential for clinical decision-making and therapeutic evaluation. This study aims to de...

Regarding “Increased Elbow Valgus Torque During Pitching Is Not a Risk Factor for Medial Elbow Injuries in Young Baseball Pitchers: A Prospective Cohort Study”

We read with great interest the study by Saito et al.1 and commend the authors for addressing an important and clinically relevant question in youth throwing injury prevention. However, we believe that several important aspects were insufficiently addressed, and we respectfully o...

Development and validation of machine learning models for preoperative prediction of perioperative outcomes in patients with thymic epithelial tumors

Thymic epithelial tumors (TETs) are rare anterior mediastinal tumors with heterogeneous perioperative recovery. We developed and externally validated machine-learning models using preoperative and preoperatively available variables to predict postoperative complications, prolonge...

FTO-mediated m6A modification of EGR1 mRNA promotes podocyte injury and inflammation via STING1 in diabetic kidney disease

Diabetic kidney disease (DKD) is the predominant cause of end-stage kidney disease, with podocyte injury being a key factor in DKD. Research has shown that RNA demethylase fat-mass and obesity-associated protein (FTO) is related to podocyte injury. In prior research, we modulated...

Direct oral anticoagulants versus vitamin K antagonists in cirrhotic portal vein thrombosis: a systematic review and meta-analysis of clinical, radiological, and safety outcomes

The optimal anticoagulant strategy for portal vein thrombosis (PVT) in patients with cirrhosis remains uncertain. This systematic review and meta-analysis compared the clinical, radiological, and safety outcomes associated with direct oral anticoagulants (DOACs) versus vitamin K...

Dupilumab as Add‐On Therapy for JAK Inhibitor‐Relapsed Pediatric Alopecia Areata: A Case Series

ABSTRACT A retrospective case series evaluated dupilumab as add‐on therapy in 15 children with severe alopecia areata who relapsed after achieving SALT80 with Janus kinase inhibitors. At Week 12, the median improvement in SALT score from baseline was 59.0%. Among the 13 patients...

Reusable R analysis modules accompanying "Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration"

This software package accompanies the manuscript Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration. The package contains six reusable R modules for data input and validation, statistical and complex-survey ana...

NoiBic: a noise-tolerant biclustering algorithm for high-throughput gene expression data analysis

Abstract Motivation High-throughput transcriptomic technologies generate large-scale gene expression datasets for functional module discovery. However, technical and biological noise can obscure coherent expression patterns and compromise module detection. Noise-tolerant methods...

Macrophage-derived MMP14 fosters immunosuppressive tumor microenvironment by regulating soluble semaphorin 4D

Abstract High expression of semaphorin 4D (SEMA4D) in tumor cells fosters an immunosuppressive tumor microenvironment (TME), yet the underlying tumor-macrophage crosstalk remains poorly understood. Here, we investigated this regulatory axis using in vitro co-cultures and SEMA4D g...

A protein-prioritised, colocalisation-informed genetic framework for safety hypothesis generation across inflammatory bowel disease therapeutic pathways

Human genetics can help prioritise target–outcome safety hypotheses before broad therapeutic exposure, but the strength and translational meaning of such signals depend on molecular proxy type, locus specificity and instrument architecture. We developed a protein-prioritised, col...

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

ABSTRACT Severe muscle fat infiltration is a contributing factor to muscle loss, particularly in the spinal sarcopenia population. However, the underlying mechanism largely remains elusive. Here, we identified the intramuscular fat fraction (IMFF), rather than perimuscular fat fr...

Prognostic value of baseline serum lactate dehydrogenase in EGFR-mutant lung adenocarcinoma treated with first-line EGFR-TKI monotherapy

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are standard first-line treatment for patients with sensitizing EGFR-mutant lung adenocarcinoma; however, treatment outcomes remain heterogeneous and acquired resistance eventually develops in most patients...

Oral and oropharyngeal bacterial microbiota in children with obstructive mouth breathing: a pilot cross-sectional study

Obstructive mouth breathing (OMB) is a common pediatric condition associated with oral and systemic health problems. OMB may alter the oral and oropharyngeal environment through mucosal dryness, reduced salivary clearance, altered airflow and gas exchange, and impaired local muco...

APOF regulates the malignancy and inflammatory response of hepatocellular carcinoma cells through PPAR signaling pathway

Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence. It is often diagnosed at an advanced stage, with intrahepatic or extrahepatic metastasis, and cannot be cured by radical surgery. In human HCC cell lines, Apolipoprotein F (APOF) gene promoter activity was s...