Seoul National University

Association of oral health with incident pancreatic cancer among individuals with atrial fibrillation: a population-based cohort study

Modifiable factors associated with pancreatic cancer risk in atrial fibrillation (AF) populations remain poorly defined. We aimed to evaluate the associations of oral health status and oral hygiene behaviors with incident pancreatic cancer in individuals with AF. Using the Korean...

G-screen: scalable protein-aware virtual screening through flexible ligand alignment

Virtual screening has long been a central computational tool for rational ligand discovery, enabling the systematic prioritization of candidate molecules from large chemical libraries. Although docking and related approaches that explicitly account for protein–ligand interactions...

Extratropical teleconnections in a multi-model ensemble nudged towards the observed QBO

The Quasi-Biennial Oscillation (QBO), the dominant mode of interannual variability of monthly-mean zonal winds and temperatures in the equatorial stratosphere, has a significant influence on the circulation in other regions of the stratosphere and troposphere in boreal winter. To...

Regional Disparities and Loneliness Among Older Adults in South Korea: The Role of Subjective Health

Despite increasing policy concerns about loneliness in later life particularly in declining regions, empirical efforts to link these issues with regional disparities remain limited. This study examines whether associations between regional factors and loneliness among older adult...

A refined MASH–HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression

Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading driver of hepatocellular carcinoma (HCC), yet the molecular mechanisms linking metabolic stress, chronic inflammation and tumorigenesis remain poorly understood. Here we established a metabo...

Is Transanal Local Excision Oncologically Safe After Chemoradiotherapy? A Multicenter Phase II Study in ycT0–1 Rectal Cancer

PurposeTo evaluate the feasibility of local excision (LE) as an organ-preserving approach in patients with locally advanced rectal cancer showing a good response to neoadjuvant chemoradiotherapy (CRT). Materials and MethodsThis prospective, multicenter, single-arm phase II study...

International Protocol for the Study of Amorphous Charred Objects in Archaeology (IPSACO 1.0)

Abstract Archaeobotanists around the world increasingly recognise that, alongside commonly studied materials such as seeds, fruits, wood charcoal, and chaff, archaeobotanical samples also contain fragments of carbonised organic (and sometimes inorganic) matter that vary in shape...

Current legislation and recommendations on ethical post-experimental care and disposition of laboratory animals: a call for global standards

The fate of laboratory animals once experiments end remains an ethical blind spot. This Comment compares the legislation governing the post-experimental care and disposition of laboratory animals—rehoming, reuse, setting free and tissue sharing—across the European Union, USA, UK...

Practice patterns and outcomes of pediatric ERCP using conventional duodenoscopes: a 14-year single-center experience

Endoscopic retrograde cholangiopancreatography (ERCP) is an established therapeutic modality in children with pancreatobiliary disorders. Because pediatric-specific duodenoscopes are not widely available, conventional adult duodenoscopes are commonly used in clinical practice. We...

Association of post-treatment ⁹⁰Y PET/CT–derived mean tumor absorbed dose with treated-lesion progression-free survival after glass-microsphere radioembolization for hepatocellular carcinoma

To assess the prognostic value of post-treatment yttrium-90 PET/CT–based dosimetry and an absorbed dose threshold for progression-free survival in large (> 8 cm) hepatocellular carcinomas treated with transarterial radioembolization. Fifty-eight patients with unresectable hepatoc...

Random exclusion codes as vector random walks

Random exclusion codes (RECs) are one-shot communication tasks in which Alice receives a uniformly random word and sends a limited physical system to Bob, who is asked to output a symbol different from the one appearing at a randomly selected coordinate. We resolve the conjecture...

Random exclusion codes as vector random walks

Random exclusion codes (RECs) are one-shot communication tasks in which Alice receives a uniformly random word and sends a limited physical system to Bob, who is asked to output a symbol different from the one appearing at a randomly selected coordinate. We resolve the conjecture...

Electrolyte Lubricants for Solid-State Batteries

Abstract Solid-state batteries (SSBs) promise higher energy density and improved safety, but interparticle voids and unstable solid–solid interfaces still limit their performance. Here, we translate the concept of lubrication into an electrolyte-lubrication strategy for SSBs. We...

Long-term exposure to ambient air pollution and an increased risk of hyperuricemia

Abstract Objectives Evidence suggests that ambient air pollution contributes to metabolic dysregulation, including hyperuricemia. However, previous studies were limited to specific groups or regions with relatively high air pollutant concentrations. This study examined the associ...

Care network types and depression among people with cognitive impairment: A latent class analysis

Depression is a common neuropsychiatric symptom in people with cognitive impairment. Although care networks, defined as groups of caregivers supporting an individual with cognitive impairment, may influence depression, evidence regarding this relationship remains limited. The pur...

Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway

Abstract Obesity, marked by visceral fat accumulation, has a complex relationship with the gut microbiome that impacts body weight and fat accumulation. However, previous studies did not account for fat distribution, reflecting only overall fat mass, leaving specifics of this rel...

Rehabilitation and airway clearance technique education in nontuberculous mycobacterial pulmonary disease: protocol for the NTM-Rehab study

BACKGROUND: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic, often progressive, respiratory infection with an increasing global incidence that is frequently accompanied by bronchiectasis. Although antimicrobial therapy is the cornerstone of treatment, culture...

An Atlas of Specificity Protein 1 in Oral Cancer: Networks, Therapeutics, and Priorities: A Scoping Review and scRNA-seq Analysis

Oral squamous cell carcinoma (OSCC) remains the most common oral malignancy and has limited targeted therapeutic options. Specificity protein 1 (Sp1), a versatile zinc-finger transcription factor, has emerged as a pivotal regulator of cellular proliferation, apoptosis, epithelial...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Anomaly Localization and Classification of Jaw Cysts and Tumours Using Anatomy-Conditioned Diffusion on Panoramic Radiographs

Objectives Accurate localization and classification of jaw cysts and tumours on panoramic radiographs are important for timely referral and treatment planning but remain challenging due to overlapping anatomy, heterogeneous lesion appearances, and dental restorations. This study...