Seoul National University

Ethylene and 1-methylcyclopropene modulate aroma volatile profiles in kiwifruit (Actinidia spp.) during postharvest storage

Abstract Kiwifruit is a climacteric fruit, and ethylene-mediated ripening accelerates quality deterioration during storage. In this study, volatile compound composition was profiled during storage for 0–10 d under control, ethylene, and 1-methylcyclopropene (1-MCP) treatments. A...

Torsional behavior of reinforced slag-based geopolymer concrete columns under compression

Although extensive research has been conducted on geopolymer concrete (GPC) at material level, its structural behavior under complex stress states remains inadequately understood, especially under combined compression and torsion. In this study, monotonic torsion tests under comb...

Circular RNA circSNRK regulates inflammatory processes and TXNIP expression by acting as a miR-128-3p sponge in age-related macular degeneration

Age-related macular degeneration (AMD) is an ocular disease that causes visual impairment in older individuals, primarily due to degeneration of the retinal pigment epithelium (RPE). In this progressive disease, damaged RPE cells release pro-inflammatory factors into the extracel...

Enhanced carbon loss in the Southern Ocean under mitigation scenarios

The Southern Ocean (SO) plays a pivotal role in the global carbon cycle by absorbing anthropogenic carbon dioxide (CO 2 ). Yet, it remains uncertain whether this role will persist under future mitigation efforts. Using idealized emission-driven simulations with the Community Eart...

Bridging primary care with artificial intelligence: toward a global 1.5-Tier Healthcare System

Artificial intelligence is increasingly applied in primary care, yet systematic frameworks linking individual applications to health-system improvement remain lacking. This perspective proposes a “1.5-Tier Healthcare System,” in which AI forms an intermediary layer between primar...

Asymmetric response of coastal currents to oscillating alongshore wind stress over a coastal bank

Abstract. An asymmetric response of coastal currents to oscillating alongshore wind stress is observed over a coastal bank off the southern coast of Korea. Alongshore currents exhibit consistently larger variability in the western region than in the eastern region. Numerical expe...

Niche-resolved transcriptional programs and ΔNp63/NRF2-associated enrichment in post-chemoradiation esophageal squamous cell carcinoma

Spatial organization in esophageal squamous cell carcinoma resection specimens after chemoradiation remains poorly characterized. We profiled 56 patients using Visium spatial transcriptomics and identified eight niches. All 37 evaluated transcriptional signatures showed marked va...

Hierarchical population structure and phylogeographic divergence in the Korean endemic salamander Hynobius notialis

Abstract Amphibian populations are strongly influenced by geographical and environmental barriers; however, the processes shaping the spatial genetic structure remain poorly understood in many East Asian taxa. We investigated the population structure and evolutionary history of t...

Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC

Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a...

Implementation of the Generalized Double-Moment scaling Normalization method for raindrop size distribution in a WRF 4.3.1 bulk-type cloud microphysics scheme: a case study over the Korean Peninsula

Abstract. This study is the first to adopt the Generalized Double-Moment scaling Normalization (GDMN) method to represent the rain Drop Size Distribution (DSD) in a bulk-type cloud microphysics scheme, specifically the Weather Research and Forecasting (WRF) Double-moment 6-class...

COBRA: Cell-type-specific Orthogonal Batch effect Removal Algorithm in single cell RNA-sequencing data

Abstract Motivation Single-cell RNA sequencing (scRNA-seq) enables high-resolution profiling of cellular heterogeneity, yet batch effects remain a critical challenge in data integration. Existing batch correction methods often assume homogeneous batch effect across cell types, op...

Three Topological Phases of the Elliptic Ginibre Ensembles with a Point Charge

Abstract We consider the complex and symplectic elliptic Ginibre matrices of size $$(c+1)N \times (c+1)N$$ ( c + 1 ) N × ( c + 1 ) N , conditioned to have a deterministic eigenvalue at $$ p \in \mathbb {R} $$ p ∈ R with multiplicity cN . We show that their limiting spectrum is ei...

Climate Inequality: Who Contributes, Who Suffers, and Who Decides?

지구는 점점

Mutation-agnostic base editing of the progerin farnesylation site rescues Hutchinson-Gilford progeria syndrome phenotypes in neuromuscular organoids

Abstract Hutchinson Gilford progeria syndrome (HGPS) is a fatal premature aging disorder caused by pathogenic farnesylated lamin A variants that disrupt nuclear architecture and DNA repair. Current therapies, including farnesyltransferase inhibitors, provide only modest survival...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

An h-likelihood approach to fitting accelerated failure time models for clustered heavily censored data

Motivated by oral health time-to-event outcomes, we focus on the analysis of clustered (tooth within subjects), heavily right-censored, survival data, where the event of interest is tooth failure. The generalized extreme value (GEV) distribution is widely used for analyzing extre...

Association between annual air pollutant exposure and thyroid function: a retrospective cross-sectional study

Abstract Aims Despite the high burden of air pollutants, the association between air pollutant exposures and thyroid function in the general population is inconclusive. This study aimed to investigate the association between annual exposure to air pollutants and thyroid function...

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Short tandem repeat (STR) expansion is a major genetic mechanism underlying numerous neurogenetic disorders. However, traditional PCR amplification and short-read next-generation sequencing-based methods often fail to detect large-scale, complex expansions and to capture methylat...

PURIFICATION OF SAPONIN-PDRN COMPLEX DERIVED FROM PLATYCODON GRANDIFLORUS BASED ON A DUAL-FUNCTIONAL MAGNETIC BEAD-COLUMN SYSTEM AND VALIDATION OF ITS IN VITRO / IN VIVO SKIN REGENERATION, BARRIER ENHANCEMENT, AND WSSV ANTIVIRAL EFFICACY

Despite the tissue regeneration effects of fish-derived polydeoxyribonucleotide (PDRN), the paradigm is shifting towards plant-derived PDRN (Phyto DNA) and complexes of plant-specific active ingredients due to the instability of marine resource supply and the risk of zoonotic inf...

Time‐dependent predictors of seizure outcome in grade 1–2 glioma‐related epilepsy

OBJECTIVE: Given the reciprocal interaction between tumor biology and seizure activity, seizure outcomes in low-grade glioma (LGG) may be dynamic and influenced by both tumor- and treatment-related factors. We aimed to identify factors associated with seizure occurrence across di...